Journal of The Korean Society of Clinical Toxicology (대한임상독성학회지)

Korean society of Clincal Toxicology (대한임상독성학회)
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A retrospective analysis of toxic alcohol poisoning

급성 독성 알코올 중독에 대한 후향적 분석

  • Jin Kim (Department of Emergency Medicine, Inha University College of Medicine) ;
  • Yu Jin Lee (Department of Emergency Medicine, Inha University College of Medicine) ;
  • Tae Kyu Ahn (Department of Emergency Medicine, Inha University College of Medicine) ;
  • Soo Kang (Department of Emergency Medicine, Inha University College of Medicine)
  • 김진 (인하대학교 의과대학 응급의학교실) ;
  • 이유진 (인하대학교 의과대학 응급의학교실) ;
  • 안태규 (인하대학교 의과대학 응급의학교실) ;
  • 강수 (인하대학교 의과대학 응급의학교실)
  • Received : 2023.10.05
  • Accepted : 2023.11.05
  • Published : 2023.12.31
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Abstract

Purpose: This study aimed to compare the clinical features of methanol and ethylene glycol poisoning. Methods: This single-center retrospective observational study included patients with toxic alcohol poisoning who visited a regional emergency medical center. Patients with methanol and ethylene glycol poisoning from January 2004 to June 2023 were selected for the study using diagnostic codes. Results: Twenty-two patients with toxic alcohol poisoning visited during the study period, with 11 patients for each category. Compared to methanol poisoning, ethylene glycol poisoning patients were more likely to have consumed alcohol for suicidal purposes (n=4 [36.36%] vs. n=8 [72.73%]) and were more likely to be drowsy (n=0 vs. n=6 [54.55%], p=0.016). The anion gap (25.43±8.35 mmol/L vs. 13.22±6.23 mmol/L, p=0.001) and lactic acid levels (1.785 [1.3-2.785] mmol/L vs. 9.90 [4.20-11.81] mmol/L, p=0.007) were higher in ethylene glycol poisoning patients than in methanol poisoning patients. Among alcohol dehydrogenase blockers, oral ethanol was administered to 10 patients (45.45%) (n=4 [36.36%] vs. n=6 [54.55%]), and intravenous ethanol was administered to six patients (n=4 [36.36%] vs. n=2 [18.18%]). Fomepizole was administered to two patients (9.09%) each, and renal replacement therapy was non-significantly more common in patients with ethylene glycol poisoning (n=8 [72.73%] vs. n=3 [27.27%], p=0.128). Three patients had delays in diagnosis and treatment, and while there were no fatalities, one patient was left with permanent vision damage. Conclusion: Because these are uncommon types of poisoning and the clinical presentation is difficult to recognize early, healthcare providers should be familiar with toxic alcohol types and screen for them to ensure proper diagnosis and treatment.

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References

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