대한임상독성학회지 (Journal of The Korean Society of Clinical Toxicology)

  • 제21권2호
  • /
  • Pages.117-127
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  • 2023
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  • 1738-1320(pISSN)
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  • 2508-6332(eISSN)
대한임상독성학회 (Korean society of Clincal Toxicology)
권호 표지
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급성일산화탄소 중독환자에서 고압산소치료의 압력에 따른 예후 비교

Comparison of hyperbaric oxygen therapy pressures for acute carbon monoxide poisoning

  • 김정윤 (연세대학교 원주의과대학 응급의학교실) ;
  • 임지혜 (연세대학교 원주의과대학 의통계학과) ;
  • 김성화 (연세대학교 원주의과대학 의통계학과) ;
  • 한상일 (연세대학교 원주의과대학 응급의학교실) ;
  • 차용성 (연세대학교 원주의과대학 응급의학교실)
  • Jeong Yun Kim (Department of Emergency Medicine, Yonsei University Wonju College of Medicine) ;
  • Jihye Lim (Department of Biostatistics and Center of Biomedical Data Science, Yonsei University Wonju College of Medicine) ;
  • Sung Hwa Kim (Department of Biostatistics and Center of Biomedical Data Science, Yonsei University Wonju College of Medicine) ;
  • Sang Il Han (Department of Emergency Medicine, Yonsei University Wonju College of Medicine) ;
  • Yong Sung Cha (Department of Emergency Medicine, Yonsei University Wonju College of Medicine)
  • 투고 : 2023.09.14
  • 심사 : 2023.10.04
  • 발행 : 2023.12.31
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초록

Purpose: No consensus currently exists regarding the maximal pressure of hyperbaric oxygen (HBO2) therapy performed within 24 hours of acute carbon monoxide (CO) poisoning. This study aimed to evaluate the difference in therapeutic effects according to the first HBO2 pressure (3.0 atmospheres absolute [ATA] vs. 2.8 ATA). Methods: We used prospectively collected registry data on CO poisoning at a tertiary academic hospital in the Republic of Korea. Adult patients with acute CO poisoning treated with HBO2 within 24 hours after arrival at the emergency department and without the use of additional HBO2 after 24 hours between January 2007 and February 2022 were included. Data from 595 patients were analyzed using propensity score matching (PSM). Patients with mild (non-intubated) and severe (intubated) poisoning were also compared. Neurocognitive outcomes at 1 month after CO poisoning were evaluated using the Global Deterioration Scale combined with neurological impairment. Results: After PSM, the neurocognitive outcomes at 1-month post-CO exposure were not significantly different between the 2.8 ATA (110 patients) and 3.0 ATA (55 patients) groups (p=1.000). Similarly, there was also no significant difference in outcomes in a subgroup analysis according to poisoning severity in matched patients (165 patients) (mild [non-intubated]: p=0.053; severe [intubated]: p=1.000). Conclusion: Neurocognitive sequelae at 1 month were not significantly different between HBO2 therapy pressures of 2.8 ATA and 3.0 ATA in patients with acute CO poisoning. In addition, the 1-month neurocognitive sequelae did not differ significantly between intubated and non-intubated patients.

키워드

과제정보

This work was supported by the Korea Medical Device Development Fund grant funded by the Korea government (the Ministry of Science and ICT) (Project Number: RS-2020-KD000247).

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