Journal of Yeungnam Medical Science

영남대 의대 학술지 편집위원회 (Yeungnam University College of Medicine, Yeungnam University Institute Medical Science)
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Hepatic ischemia-reperfusion injury with respect to oxidative stress and inflammatory response: a narrative review

  • Eun Kyung Choi (Department of Anesthesiology and Pain Medicine, Yeungnam University College of Medicine) ;
  • Dong Gun Lim (Department of Anesthesiology and Pain Medicine, School of Medicine, Kyungpook National University)
  • 투고 : 2022.01.06
  • 심사 : 2022.02.17
  • 발행 : 2023.04.30
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초록

Hepatic ischemia-reperfusion injury is a major complication of liver transplantation, trauma, and shock. This pathological condition can lead to graft dysfunction and rejection in the field of liver transplantation and clinical hepatic dysfunction with increased mortality. Although the pathological mechanisms of hepatic ischemia-reperfusion injury are very complex, and several intermediators and cells are involved in this phenomenon, oxidative stress and inflammatory responses are the key processes that aggravate hepatic injury. This review summarizes the current understanding of oxidative stress and inflammatory responses and, in that respect, addresses the therapeutic approaches to attenuate hepatic ischemia-reperfusion injury.

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참고문헌

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