Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
권호 표지
DOI QR코드

DOI QR Code

Paraneoplastic Hypereosinophilia in a Dog with Intestinal T-Cell Lymphoma

  • Ji-Seon Yoon (College of Veterinary Medicine, Jeonbuk National University) ;
  • Hyeona Bae (College of Veterinary Medicine, Gyeongsang National University) ;
  • Hee-Chun Lee (College of Veterinary Medicine, Gyeongsang National University) ;
  • Dong-In Jung (College of Veterinary Medicine, Gyeongsang National University) ;
  • Sang-Ki Kim (College of Industrial Science, Kongju National University) ;
  • Dae Young Kim (College of Veterinary Medicine, University of Missouri) ;
  • DoHyeon Yu (College of Veterinary Medicine, Gyeongsang National University)
  • Received : 2023.01.07
  • Accepted : 2023.01.30
  • Published : 2023.02.28
Download PDF
⟨ Previous Next ⟩

Abstract

Paraneoplastic hypereosinophilia, characterized by the infiltration of eosinophils into systemic organs, has rarely been reported in dogs with intestinal lymphoma. A 12-year-old spayed female Maltese with eosinophilia in the peripheral blood and ascites was found to have muscular layer thickening in the small intestine. Histologically, there was transmural infiltration of small to intermediate sized neoplastic lymphocytes that were immunohistochemically CD3-/CD79a-. PCR for antigen receptor rearrangement demonstrated clonal T cell receptor gene population. A moderate number of eosinophils were present along with neoplastic lymphocytes in the small intestine, and eosinophil infiltration was also noted in the abdominal lymph nodes and spleen. The present case reports intestinal T-cell lymphoma with generalized paraneoplastic hypereosinophilia. Clinicians should be aware that hypereosinophilia can be found in the organs, body cavity fluid, and peripheral blood of dogs with intestinal lymphoma.

Keywords

Acknowledgement

This research was supported by Korea Institute of Planning and Evaluation for Technology in Food, Agriculture and Forestry (IPET) through Companion Animal Life Cycle Industry Technology Development Program, funded by Ministry of Agriculture, Food and Rural Affairs (MAFRA) (322092-04-1-HD030).

References

  1. Bergman P. Paraneoplastic syndromes. In: Withrow SJ, Vail DM, Page RL, editors. Withrow and MacEwen's small animal clinical oncology. 5th ed. St. Louis: Elsevier. 2013: 83-97. 
  2. Coyle KA, Steinberg H. Characterization of lymphocytes in canine gastrointestinal lymphoma. Vet Pathol 2004; 41: 141-146.  https://doi.org/10.1354/vp.41-2-141
  3. Cyriac S, Sagar TG, Rajendranath R, Rathnam K. Hypereosinophilia in Hodgkin lymphoma. Indian J Hematol Blood Transfus 2008; 24: 67-68.  https://doi.org/10.1007/s12288-008-0031-x
  4. Gieger T. Alimentary lymphoma in cats and dogs. Vet Clin North Am Small Anim Pract 2011; 41: 419-432.  https://doi.org/10.1016/j.cvsm.2011.02.001
  5. Guija de Arespacochaga A, Schwendenwein I, Weissenbock H. Retrospective study of 82 cases of canine lymphoma in Austria based on the Working Formulation and immunophenotyping. J Comp Pathol 2007; 136: 186-192.  https://doi.org/10.1016/j.jcpa.2007.01.009
  6. Lilliehook I, Tvedten H. Investigation of hypereosinophilia and potential treatments. Vet Clin North Am Small Anim Pract 2003; 33: 1359-1378.  https://doi.org/10.1016/S0195-5616(03)00097-4
  7. Marchetti V, Benetti C, Citi S, Taccini V. Paraneoplastic hypereosinophilia in a dog with intestinal T-cell lymphoma. Vet Clin Pathol 2005; 34: 259-263.  https://doi.org/10.1111/j.1939-165X.2005.tb00051.x
  8. McNaught KA, Morris J, Lazzerini K, Millins C, Jose-Lopez R. Spinal extradural T-cell lymphoma with paraneoplastic hypereosinophilia in a dog: clinicopathological features, treatment, and outcome. Clin Case Rep 2018; 6: 999-1005.  https://doi.org/10.1002/ccr3.1503
  9. Murata K, Yamada Y, Kamihira S, Atogami S, Tsukasaki K, Momita S, et al. Frequency of eosinophilia in adult T-cell leukemia/lymphoma. Cancer 1992; 69: 966-971.  https://doi.org/10.1002/1097-0142(19920215)69:4<966::AID-CNCR2820690422>3.0.CO;2-H
  10. Shin SW, Lim Y, Bae H, Kim J, Cho AR, Park J, et al. CD3+/CD4+/CD5+/CD8+/CD21+/CD34-/CD45-/CD79a-/TCRαβ+/TCRγδ-/MHCII+ T-zone lymphoma in a dog with generalized lymphadenopathy: a case report. Korean J Vet Res 2021; 61: e21. 
  11. Tancrede-Bohin E, Ionescu MA, de La Salmoniere P, Dupuy A, Rivet J, Rybojad M, et al. Prognostic value of blood eosinophilia in primary cutaneous T-cell lymphomas. Arch Dermatol 2004; 140: 1057-1061.  https://doi.org/10.1001/archderm.140.9.1057
  12. Tomiyasu H, Fujino Y, Ugai J, Goto-Koshino Y, Ide T, Takahashi M, et al. Eosinophilia and eosinophilic infiltration into splenic B-cell high-grade lymphoma in a dog. J Vet Med Sci 2010; 72: 1367-1370.  https://doi.org/10.1292/jvms.09-0544
  13. Verbeek WH, Goerres MS, von Blomberg BM, Oudejans JJ, Scholten PE, Hadithi M, et al. Flow cytometric determination of aberrant intra-epithelial lymphocytes predicts T-cell lymphoma development more accurately than T-cell clonality analysis in Refractory Celiac Disease. Clin Immunol 2008; 126: 48-56.  https://doi.org/10.1016/j.clim.2007.09.002
  14. Weidmann E. Hepatosplenic T cell lymphoma. A review on 45 cases since the first report describing the disease as a distinct lymphoma entity in 1990. Leukemia 2000; 14: 991-997.  https://doi.org/10.1038/sj.leu.2401784
  15. Zandvliet M. Canine lymphoma: a review. Vet Q 2016; 36: 76-104. https://doi.org/10.1080/01652176.2016.1152633