Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Red Ginseng Marc and Steamed Extraction Powder Enhance Proliferation and Inflammatory Cytokine Modulation in Canine PBMCs Stimulated by IL-2

  • Ju-Hyun An (Department of Veterinary Emergency and Critical Care Medicine and Institute of Veterinary Science, College of Veterinary Medicine, Kangwon National University) ;
  • Qiang Li (Department of Veterinary Medicine, College of Agriculture, Yanbian University) ;
  • Su-Min Park (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University) ;
  • Kyoung-Bo Kim (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University) ;
  • Yeong-Deuk Yi (Korea Ginseng Corporation) ;
  • Yong-Bum Song (ARK Co.) ;
  • Woo-Jin Song (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine and Research Institute of Veterinary Science, Jeju National University) ;
  • Hwa-Young Youn (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University)
  • Received : 2022.10.28
  • Accepted : 2023.01.16
  • Published : 2023.02.28
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Abstract

The growing market for companion animals, combined with their increasing lifespan, has generated an increased interest in companion animal immunity enhancers. Ginsenoside, a saponin component of ginseng and an essential ingredient of red ginseng marc (produced during red ginseng production), is effective in improving immunity. In this experiment, a powder mixture of red ginseng marc and steamed red ginseng extract powder (RGME) was orally administered to dogs for eight weeks. Subsequently, blood samples were collected and tested every four weeks. In addition, canine peripheral blood mononuclear cells (cPBMCs) were stimulated with or without interleukin-2 (IL-2) to evaluate their proliferation and cytokine secretion abilities. Proliferation assay suggests that the administration of RGME effectively enhanced numbers of cPBMCs under IL-2 stimulation. Furthermore, in the RGME group, a significant increase in the concentration of interferon gamma released from cPBMCs under IL-2 stimulation was observed. In conclusion, RGME might be an effective health supplement for improving immunity in dogs.

Keywords

Acknowledgement

This study was funded by the National Research Foundation (NRF) of Korea grant funded by the Korea government (MSIT) (NRF-2021R1F1A1063399).

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