한국환경보건학회지 (Journal of Environmental Health Sciences)

  • 제49권1호
  • /
  • Pages.11-21
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  • 2023
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  • 1738-4087(pISSN)
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  • 2233-8616(eISSN)
한국환경보건학회 (Korean Society of Environmental Health)
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대체후보물질 탐색 알고리즘 개발을 위한 국내·외 기술동향 조사 연구

Review of Domestic and Foreign Technology Trends for the Development of Exploring Alternative Candidate Algorithms

  • 최지원 (한국화학연구원 화학안전연구센터) ;
  • 박종서 (한국화학연구원 화학안전연구센터) ;
  • 서명원 (한국화학연구원 화학안전연구센터) ;
  • 이영민 (한국화학연구원 화학안전연구센터) ;
  • 김선미 (한국화학연구원 화학안전연구센터)
  • Jiwon Choi (Chemical Safety Research Center, Korea Research Institute of Chemical Technology) ;
  • Jongseo Park (Chemical Safety Research Center, Korea Research Institute of Chemical Technology) ;
  • Myungwon Seo (Chemical Safety Research Center, Korea Research Institute of Chemical Technology) ;
  • Young-Min Lee (Chemical Safety Research Center, Korea Research Institute of Chemical Technology) ;
  • Sunmi Kim (Chemical Safety Research Center, Korea Research Institute of Chemical Technology)
  • 투고 : 2023.01.20
  • 심사 : 2023.02.21
  • 발행 : 2023.02.28
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초록

Background: The need to develop alternative chemicals is increasing worldwide due to the strengthening of global chemical regulations and consumer safety awareness in the marketplace. Objectives: We aimed to review domestic and foreign technology trends for exploring alternative candidate algorithms that can be used to develop safer alternatives to strengthen global market competitiveness and protect public health in the future. Methods: We searched the current status of research trends, companies related to the development of alternative chemicals in domestic and foreign countries. For this, we referred to research papers and websites by companies and institutes related to such alternatives. Results: Among the domestic and foreign research trends, more studies in South Korea were focused on predicting molecular-based physicochemical properties and toxicity than were reporting on research exploring alternative candidates. Three web-based databases and six tools were being developed. More studies in other countries predicted information to consider in alternative development than reported on research exploring alternative candidates, and four web-based databases and three tools were being developed. Among the companies related to the development of alternative chemicals, 286 alternatives classified as 'EVALUATED ALTERNATIVE' in MARKETPLACE accounted for the most significant proportion in Europe on a continent basis, and the largest number in the United States (US) on a national basis. In South Korea, only significant companies were registered. Conclusions: In this study, it was found to be necessary to provide public technology support platforms to explore alternative candidates considering various aspects in order to support alternative development. In conclusion, exploring alternative candidate algorithms could contribute to the response to the global trends in the chemical industry and to supporting companies and researchers developing safer alternatives in the future.

키워드

과제정보

본 결과물은 과학기술정보통신부의 재원으로 한국화학연구원의 화학소재 빅데이터 플랫폼 구축(KK2351-10)과 화학물질·제품 안전설계 플랫폼 기술구축(KK2352-10) 과제의 일환으로 수행되었으며, 이에 감사드립니다.

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