Animal Bioscience

Asian Australasian Association of Animal Production Societies (아세아태평양축산학회)
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Improving productivity in rabbits by using some natural feed additives under hot environmental conditions - A review

  • Magdy Abdelsalam (Department of Animal Production and Breeding, College of Agriculture and Veterinary Medicine, Qassim University) ;
  • Moataz Fathi (Department of Animal Production and Breeding, College of Agriculture and Veterinary Medicine, Qassim University)
  • Received : 2022.09.13
  • Accepted : 2022.12.24
  • Published : 2023.04.01
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Abstract

Heat stress is a major challenge to animal production in tropical and subtropical climates. Rabbits suffer from heat stress more than farm animals because they have few sweat glands, and their bodies are covered with thick fur. Intensive farming relies on antibiotics as antimicrobials or growth promoters to increase animals' productivity and health. However, the European Union and many countries have banned or restricted the use of antibiotics in animal feed for human health concerns. Several studies have found that replacing antibiotics in rabbit feed with natural plants or feed additives increases productivity and improves immune capacity, especially under heat stress conditions. Growth performance, immune response, gut microflora, and carcass yield may be increased in rabbits fed a diet supplemented with some natural plants and/or propolis. In this review article, we discuss and summarize the effects of some herbs and plant extracts as alternative feed additives on rabbit productivity, especially for those raised under hot ambient temperatures.

Keywords

References

  1. Maya-Soriano MJ, Taberner E, Sabes-Alsina M, et al. Daily exposure to summer temperatures affects the motile subpopulation structure of epididymal sperm cells but not male fertility in an in vivo rabbit model. Theriogenology 2015;84: 384-9. https://doi.org/10.1016/j.theriogenology.2015.03.033 
  2. Matics Z, Gerencser Z, Kasza R, et al. Effect of ambient temperature on the productive and carcass traits of growing rabbits divergently selected for body fat content. Animal 2021;15:100096. https://doi.org/10.1016/j.animal.2020.100096 
  3. Oladimeji AM, Johnson TG, Metwally K, Farghly M, Mahrose KM. Environmental heat stress in rabbits: implications and ameliorations. Int J Biometeorol 2022;66:1-11. https://doi.org/10.1007/s00484-021-02191-0 
  4. Pei Y, Wu Y, Qin Y. Effects of chronic heat stress on the expressions of heat shock proteins 60, 70, 90, A2, and HSC70 in the rabbit testis. Cell Stress Chaperones 2012;17:81-7. https://doi.org/10.1007/s12192-011-0287-1 
  5. El-Badawi AY, El-Wardany I, Abd El-Moez SI, et al. Impact of dietary Moringa oleifera leaves on intestinal pathogenic load and histological structure of growing rabbits raised under heat-stress conditions. Anim Prod Sci 2018;58:1901-7. https://doi.org/10.1071/AN16540 
  6. Farghly MFA, Mahrose KM, Mahmoud GB, et al. Lighting programs as an appliance to improve growing New Zealand white rabbit's performance. Inter J Biometeorol 2020;64:1295-303. https://doi.org/10.1007/s00484-020-01906-z 
  7. Foldesiova M, Balazi A, Chrastinova L, et al. Yucca schidigera can promote rabbit growth, fecundity, affect the release of hormones in vivo and in vitro, induce pathological changes in liver, and reduce ovarian resistance to benzene. Anim Reprod Sci 2017;183:66-76. https://doi.org/10.1016/j.anireprosci.2017.06.001 
  8. Selim S, Seleiman MF, Hassan MM, Saleh AA, Mousa MA. Impact of Dietary Supplementation with Moringa oleifera Leaves on Performance, Meat Characteristics, Oxidative Stability, and Fatty Acid Profile in Growing Rabbits. Animals 2021:11:248. https://doi.org/10.3390/ani11020248 
  9. Yasoob TB, Yu D, Khalid AR, et al. Oral administration of Moringa oleifera leaf powder relieves oxidative stress, modulates mucosal immune response and cecal microbiota after exposure to heat stress in New Zealand White rabbits. J Anim Sci Biotechnol 2021;12:66. https://doiorg/101186/s40104-021-00586-y  101186/s40104-021-00586-y
  10. Salem MI, El-Sebai A, Elnagar SA, Abd El-Hady AM. Evaluation of lipid profile, antioxidant and immunity statuses of rabbits fed Moringa oleifera leaves. Anim Biosci 2022 Oct 18 [Epub]. https://doi.org/10.5713/ajas.20.0499 
  11. Ashour E, Alagawany M, Reda F, Abd El-Hack M. Effect of supplementation of yucca schidigera extract to growing rabbit diets on growth performance, carcass characteristics, serum biochemistry and liver oxidative status. Asian J Anim Vet Adv 2014;9:732-742. https://doi.org/10.3923/ajava.2014.732.742 
  12. Zendrato DP, Ginting R, Warisman, et al. Growth performance of weaner rabbits fed dried Moringa oleifera leaf meal. IOP Conf Ser Earth Environ Sci 2019;260:012058. https://doi.org/10.1088/1755-1315/260/1/012058 
  13. El-Adawy MM, El-Komy AM, Rashad AM, Fahmy WG, Abd El-Aziz NA. The influence of dried moringa oleifera leaves in feeding of growing rabbits 1- growth performance nutrients digestibility nitrogen utilization and economical efficiency. Egypt Poult Sci J 2020;40:753-68.  https://doi.org/10.21608/epsj.2020.134962
  14. Waly AH, Abo El-Azayem EH, Younan GE, Zedan AH, El-Komy HMA, Mohamed RA. Effect of propolis supplementation on growth performance nutrients digestibility carcass characteristics and meat quality of growing New Zealand rabbits. Egypt J Nutr Feeds 2021;24:65-73.  https://doi.org/10.21608/ejnf.2021.210779
  15. Nader MA, El-Agamy DS, Suddek GM. Protective effects of propolis and thymoquinone on development of atherosclerosis in cholesterol-fed rabbits. Arch Pharm Res 2010;33:637-43. https://doi.org/10.1007/s12272-010-0420-1 
  16. Nosal P, Kowalska D, Bielaoski P, Kowal J, Kornas S. Herbal formulations as feed additives in the course of rabbit subclinical coccidiosis. Ann Parasitol 2014;60:65-9. 
  17. Fathi MM, Abdelsalam M, Al-Homidan I, et al. Supplemental effects of eucalyptus (eucalyptus camaldulensis) leaves on growth performance, carcass characteristics, blood biochemistry and immune response of growing rabbits. Ann Anim Sci 2019;19:779-91. https://doi.org/10.2478/aoas-2019-0023 
  18. Ayodele AE, Adeola JR, Mayowa AT. Reproductive performance of rabbit does fed graded levels of moringa oleifera leaf meal based diet. Int J Sci 2014;3:50-3.
  19. El-Desoky AMI, Alazab AM, Bakr ELO, Elseady YA. Effect of adding moringa leaf meal to rabbit diets on some productive and reproductive performance traits. Egypt J Rabbit Sci 2018; 28:263-86.  https://doi.org/10.21608/ejrs.2018.44115
  20. Attia YA, Bovera F, El-Hamid A, Nagadi SA, Mandour MA, Hassan SS. Bee pollen and propolis as dietary supplements for rabbit: Effect on reproductive performance of does and on immunological response of does and their offspring. J Anim Physiol Anim Nutr 2019;103:959-68. https://doi.org/10.1111/jpn.13069 
  21. Svoradova A, Balazi A, Chrenek P. Effect of selected natural and synthetic substances on rabbit reproduction-A mini review. J Anim Physiol Anim Nutr 2022;106:622-9. https://doi.org/10.1111/jpn.13641 
  22. Chrenkova M, Chrastinova L, Polacikova M, et al. The effect of yucca schidigera extract in diet of rabbits on nutrient digestibility and qualitative parameters in caecum. Slovak J Anim Sci 2012;45:83-8. 
  23. El-Badawi AY, Omer HAA, Abedo AA, Yacout MHM. Response of growing New Zealand white rabbits to rations supplemented with different levels of Moringa oleifera dry leaves. Glob Vet 2014;12:573-82. 
  24. Cornara L, Biagi M, Xiao J, Burlando B. Therapeutic properties of bioactive compounds from different honeybee products. Front Pharmacol 2017;8:412. https://doi.org/10.3389/fphar.2017.00412 
  25. Dalle Zotte A, Sartori A, Bohatir P, Remignon H, Ricci R. Effect of dietary supplementation of Spirulina (Arthrospira platensis) and Thyme (Thymus vulgaris) on growth performance, apparent digestibility and health status of companion dwarf rabbits. Livest Sci 2013;152:182-91. https://doi.org/10.1016/j.livsci.2012.12.017 4
  26. Rotolo L, Gai F, Nicola S, Zoccarato I, Brugiapaglia A, Gasco L. Dietary supplementation of oregano and sage dried leaves on performances and meat quality of rabbits. J Integr Agric 2013;12:1937-45. https://doi.org/10.1016/S2095-3119(13)60631-0 
  27. Daader AH, Al-Sagheer AA, Gabr HA, Abd El-Moniem EA. Alleviation of heat-stress-related physiological perturbations in growing rabbits using natural antioxidants. Spanish J Agric Res 2018;16:e0610. https://doi.org/10.5424/sjar/2018163-13184 
  28. Habeeb AA, El-Darawany AA, Nasr AS, Sharaf AK. Impact of some medicinal plants supplement on pregnant rabbits diet during hot summer season. Res J Med Plant 2019;13:145-54.  https://doi.org/10.3923/rjmp.2019.145.154
  29. El-Ratel IT, Attia KA, El-Raghi AA, Fouda SF. Relief of the negative effects of heat stress on semen quality, reproductive efficiency and oxidative capacity of rabbit bucks using different natural antioxidants. Anim Biosci 2021;34:844-54. https://doi.org/10.5713/ajas.20.0258 
  30. Gopalakrishnan L, Doriya K, Kumar DS. Moringa oleifera: A review on nutritive importance and its medicinal application. Food Sci Hum Wellness 2016;5:49-56. https://doi.org/10.1016/j.fshw.2016.04.001 
  31. Abd Rani NZ, Husain K, Kumolosasi E. Moringa Genus: A Review of phytochemistry and pharmacology. Front Pharmacol 2018;9:108. https://doi.org/10.3389/fphar.2018.00108 
  32. Konmy BBS, Olounlade PA, Doko Allou S, Azando EVB, Hounzangbe-Adote MS. A review on phytochemistry and pharmacology of Moringa oleifera leaves (Moringaceae). J pharmacogn phytochem 2016;5:325-30. 
  33. Olatunji AK, Alagbe OJ, Hammed MA. Effect of varying levels of moringa olifera leaf meal on performance and blood profile of weaner rabbits. Int J Sci Res 2016;5:803-6.  https://doi.org/10.21275/v5i6.NOV164247
  34. Saalu LC, Osinubi AA, Akinbami AA, Yama OE, Oyewopo AO, Enaibe BU. Moringa oleifera lamarck (drumstick) leaf extract modulates the evidences of hydroxyurea -induced testicular derangement. Int J Appl Res Nat Prod 2011;4:32-45. 
  35. Isitua CC, Ibeh IN. Toxicological assessment of aqueous extract of Moringa oleifera and Caulis bambusae leaves in rabbits. J Clin Toxicol 2013;12:003. https://doi.org/10.4172/2161-0495.S12-003 
  36. Badawi YK, El-Sawy MA, Ramadan NA. Impact of dietary supplementation with moringa (moringa oleifera) on productive performance physiological response and immunity of growing rabbits. Egypt J Rabbit Sci 2017;27:325-39.  https://doi.org/10.21608/ejrs.2017.46581
  37. Walshaw S. Plant resources of tropical Africa 2 vegetables. Econ Bot 2005;59:401-2.  https://doi.org/10.1663/0013-0001(2005)059[0401:DFABRE]2.0.CO;2
  38. Nuhu F. Effect of Moringa leaf meal (MOLM) on nutrient digestibility growth carcass and blood indices of weaner rabbits [MSc Thesis]. Kumasi, Ghana: Kwame Nkrumah University of Science and Technology; 2010. https://hdl.handle.net/123456789/337 
  39. Omara ME, Ghada S, El-Esawy WA, Riad and Mohi El-Din AMA. Effects of supplementing rabbit diets with Moringa oleifera dry leaves at different levels on their productive performance. Egypt J Nutr Feeds 2018;21:443-53. https://doi.org/10.21608/EJNF.2018.75584 
  40. Alabi OJ, Malik AD, Ng'ambi JW, Obaje P, Ojo BK. Effect of aqueous Moringa oleifera (Lam) leaf extracts on growth performance and carcass characteristics of Hubbard broiler chicken. Braz J Poult Sci 2017;19:273-80. https://doi.org/10.1590/1806-9061-2016-0373 
  41. El-Kholy KH, Barakat SA, Morsy WA, Abdel-Maboud K, Seif-Elnaser MI, Ghazal MN. Effect of aqueous extract of moringa oleifera leaves on some production performance and microbial ecology of the gastrointestinal tract in growing rabbits. Pak J Nut 2018;17:1-7.  https://doi.org/10.3923/pjn.2018.1.7
  42. Bakr EOA, Abdel-Samee AM, Shetaewi MM. Productivity and blood biochemichal changes in rabbits fed moringa oleifera leaves meal as an untraditional source of protein under north sinai conditions. Egypt J Nutr Feeds 2019;22:131-40.  https://doi.org/10.21608/ejnf.2019.75848
  43. Khalil WA, Rehab FSA Ismail, El-Ratel IT. Efficacy of dietary moringa oleifera leaves supplementation on productivity, carcass traits, hemato-biochemical parameters, antioxidants status and immune response in heat stressed growing rabbits. Egypt J Nutr Feeds 2019;22:521-34.  https://doi.org/10.21608/ejnf.2019.79444
  44. Jiwuba PDC, Ogbuewu IP. Potential of moringa oleifera leaf meal to replace soybean meal in rabbit diets and its influence on production parameters. Asian J Biol Sci 2019;12:656-63.  https://doi.org/10.3923/ajbs.2019.656.663
  45. Aljohani NE, Abduljawad SH. Efficacy of moringa oleifera leaf supplementation for enhanced growth performance, haematology and serum biochemistry of rabbits. Food Nutr Sci 2018;9;1285-98. https://doi.org/10.4236/fns2018911092 
  46. Abubakar M, Ibrahim U, Yusuf AU, Muhammad AS, Adamu N. Growth performance, carcass and organ characteristics of growing rabbits fed graded levels of Moringa oleifera leaf meal in diets. Bayero J Pure Appl Sci 2015;8:7-9. https://doi.org/10.4314/bajopas.v8i2.2 
  47. Djakalia B, Guichord BL, Soumaila D. Effect of moringa oleifera on growth performance and health status of young post-weaning rabbits. Res J Poult Sci 2011;4:7-13.  https://doi.org/10.3923/rjpscience.2011.7.13
  48. Sun B, Zhang Y, Ding M, et al. Effects of Moringa oleifera leaves as a substitute for alfalfa meal on nutrient digestibility, growth performance, carcass trait, meat quality, antioxidant capacity and biochemical parameters of rabbits. J Anim Physiol Anim Nutr 2018;102:194-203. https://doi.org/10.1111/jpn.12678 
  49. Gomaa AA, Rashwan AA, Tewfik MI. Growth performance, carcass traits and blood constituents of weaned new zealand white rabbits as affected by inclusion dietary moringa oleifera leaf meal (molm) in their ration. J Prod Dev 2017;22:11-28.  https://doi.org/10.21608/jpd.2017.41703
  50. Ghomsi MOS, Enow JT, Etchu KA, et al. Effect of Moringa Oleifera leaf meal (Molm) on the growth, carcass, heamatology and biochemical parameters of rabbits. SOJ Vet Sci 2017;3:1-5. https://doi.org/10.15226/2381-2907/3/3/00133 
  51. Abiodun AA, Olubisi EE. Growth performance and organ indices of rabbit bucks fed moringa oleifera leaf meal. World Appl Sci J 2017;35:1229-34. 
  52. Hernandez-Fuentes AD, Soto-Simental S, Zepeda-Bastida A, Ocampo-Lopez J, Ayala-Martinez M. Productive performance, carcass traits, meat quality and blood profile in rabbits fed with moringa oleifera. Anim Sci: Nutr Anim Prod 2020;270-81. https://doi.org/10.37885/200901472 
  53. Mos G, Enow JT, Etchu KA, et al. Effect of moringa oleifera leaf meal (molm) on the growth, carcass, heamatology and biochemical parameters of rabbits. SOJ Vet Sci 2017;3:1-5. https://doi.org/10.15226/2381-2907/3/3/00133 
  54. Debola OO, Olayinka AV, Joshua A, et al. Physiological responses of rabbits fed graded levels of Moringa-based diet. Agric Stud 2021;5:20-9.  https://doi.org/10.31058/j.as.2021.52003
  55. Sebei K, Sakouhi F, Herchi W, Khouja ML, Boukhchina S. Chemical composition and antibacterial activities of seven Eucalyptus species essential oils leaves. Biol Res 2015;48:7. https://doi.org/10.1186/0717-6287-48-7 
  56. Salem AZM, Cardoso D, Camacho LM, Montanez OD, Cruz B, Olivares J. Plants rich-phytochemicals in rabbits feeding. In: Salem AFZ, editor. Plant-phytochemicals in animal nutrition (Chapter 5). New York, USA: Nova Science Publishers Inc; 2011. 
  57. Barra A, Coroneo V, Dessi S, Cabras P, Angioni A. Chemical variability antifungal and antioxidant activity of Eucalyptus camaldulensis essential oil from Sardinia. Nat Prod Commun 2010;5:329-35.  https://doi.org/10.1177/1934578X1000500232
  58. Bokaeian M, Nakhaee A, Moodi B, Khazaei HA. Eucalyptus globulus (Eucalyptus) treatment of candidiasis in normal and diabetic rats. Iran Biomed J 2010;14:121-6. 
  59. Farhadi D, Karimi A, Sadeghi G, Sheikhahmadi A, Habibian M, Sobhani K. Effects of using eucalyptus (Eucalyptus globulus L.) leaf powder and its essential oil on growth performance and immune response of broiler chickens. Iran J Vet Res 2017;18:60-2. 
  60. Dogan G, Kara N, Bagci E, Gur S. Chemical composition and biological activities of leaf and fruit essential oils from Eucalyptus camaldulensis. Z Naturforsch J Biosci 2017;72:483-9. https://doi.org/10.1515/znc-2016-0033 
  61. Mancini S, Secci G, Preziuso G, Parisi G, Paci G. Ginger (Zingiber officinale Roscoe) powder as dietary supplementation in rabbit: life performances, carcass characteristics and meat quality. Ital J Anim Sci 2018;17:867-72. https://doi.org/10.1080/1828051X.2018.1427007 
  62. Parisi F, Mancini S, Mazzei M, et al. Effect of dietary supplementation of a mix of chestnut and quebracho tannins on intestinal morphology, bacterial load, Eimeria spp oocyst excretion and immune response after vaccination in rabbits. Am J Anim Vet Sci 2018;13:94-103.  https://doi.org/10.3844/ajavsp.2018.94.103
  63. Mancini S, Moruzzo R, Minieri S, et al. Dietary supplementation of quebracho and chestnut tannins mix in rabbit: effects on live performances, digestibility, carcase traits, antioxidant status, faecal microbial load and economic value. Ital J Anim Sci 2019;18:621-9. https://doi.org/10.1080/1828051X.2018.1549514 
  64. Serafino A, Vallebona PS, Andreola F, et al. Stimulatory effect of Eucalyptus essential oil on innate cell-mediated immune response. BMC Immunol 2008;9:17. https://doi.org/10.1186/1471-2172-9-17 
  65. Sadlon AE, Lamson DW. Immune-modifying and antimicrobial effects of eucalyptus oil and simple inhalation devices. Altern Med Rev 2010;15:33-47. 
  66. Al Salman NTS, Al-Gharawi JKM. Effect of eucalyptus leaves water extract on some productive traits of broilers. Plant Arch 2019;19:920-3. 
  67. Mohebodini H, Jazi V, Ashayerizadeh A, Toghyani M, TellezIsaias G. Productive parameters, cecal microflora, nutrient digestibility, antioxidant status, and thigh muscle fatty acid profile in broiler chickens fed with Eucalyptus globulus essential oil. Poult Sci 2021;100:100922. https://doi.org/10.1016/j.psj.2020.12.020 
  68. Manh NS, Wanapat M, Uriyapongson S, Khejornsart P, Chanthakhoun V. Effect of eucalyptus (Camaldulensis) leaf meal powder on rumen fermentation characteristics in cattle fed on rice straw. African J Agric Res 2012;7:1997-2003. https://doi.org/10.5897/AJAR111347 
  69. Ahmed FG, Yacout MH, Abo-Donia FM. Effect of using eucalyptus globulus leaves in growing rabbits diets. Egypt J Rabbit Sci 2005;15:1-11. 
  70. Kaur M, Kumar R, Mondal BC, et al. Effect of supplementation of eucalyptus (eucalyptus globulus) leaf powder in diet containing phytase enzyme on performance of commercial laying hens. Ind J Vet Sci Biotechnol 2022;18:28-33. https://doi.org/10.21887/ijvsbt.18.1.6 
  71. Waly AH, Ragab AA, Quta EAH, Abo El-Azayem EH, Samia M, Mobarez SM. Growth performance, nutrients digestibility and some blood constituents in growing new zealand white rabbits fed diets supplemented with eucalyptus globules. J Anim Poult Prod 2019;10:231-5.  https://doi.org/10.21608/jappmu.2019.53492
  72. Bello AU. The effects of blue gum (Eucalyptus Globulus) leaves as feed additive on hematological traits of Japanese quail. Int J Life Sci Res 2015;3:85-9. 
  73. Liu HW, Dong XF, Tong JM, Zhang Q. A comparative study of growth performance and antioxidant status of rabbits when fed with or without chestnut tannins under high ambient temperature. Anim Feed Sci Technol 2011;164:89-95. https://doi.org/10.1016/j.anifeedsci.2010.09.020 
  74. Chen Y, Chen H, Li W, et al. Polyphenols in Eucalyptus leaves improved the egg and meat qualities and protected against ethanol-induced oxidative damage in laying hens. J Anim Physiol Anim Nutr 2018;102:214-23. https://doi.org/10.1111/jpn.12680 
  75. Abaza IM, El-Said H. Effect of using yucca schidigera as feed additive on performance of growing rabbits. The 4th International Conference on Rabbit Production in Hot Climates; Sharm El-Sheikh, Egypt; 2005. pp. 259-66. 
  76. Balazi A, Foldesiova M, Chrastinova L, Sirotkin AV, Chrenek P. Effect of the herbal additive "yucca" on rabbit spermatozoa characteristics. J Microbiol Biotechnol Food Sci 2013;2:1829-37. 
  77. Alagawany M, Ashour FA, Reda FM. Effect of dietary supplementation of garlic (Allium sativum) and turmeric (Curcuma longa) on growth performance, carcass traits, blood profile and oxidative status in growing rabbits. Ann Anim Sci 2016; 16:489-505. https://doi.org/10.1515/aoas-2015-0079 
  78. Farag MR, Alagawany M, Tufarelli V. In vitro antioxidant activities of resveratrol, cinnamaldehyde and their synergistic effect against cyadox-induced cytotoxicity in rabbit erythrocytes. Drug Chem Toxic 2017;40:196-205. https://doi.org/10. 1080/01480545.2016.1193866  https://doi.org/10.1080/01480545.2016.1193866
  79. El-Sheshtawy S, Samak D, Nada M, El Hafeez M, El-Samahy A. Protective effect of Yucca Schidigera extract against lead induced-toxicity in New Zealand male rabbits. Damanhour J Vet Sci 2021;6:16-24.  https://doi.org/10.21608/djvs.2021.99576.1054
  80. Piacente S, Pizza C, Oleszek W. Saponins and phenolics of Yucca schidigera Roezl: Chemistry and bioactivity. Phytochem Rev 2005;4:177-90. https://doi.org/10.1007/s11101-005-1234-5 
  81. Cheeke PR, Piacente S, Oleszek W. Anti-inflammatory and anti-arthritic effects of Yucca schidigera: a review. J Inflam 2006;3:6. https://doi.org/10.1186/1476-9255-3-6 
  82. Foldesiova M, Balazi A, Chrastinova L, Chrenek P. Effect of yucca schidigera herbal extract in diet on weight gains of rabbit does (preliminary results). Slovak J Anim Sci 2013;46:81-5. 
  83. Aazami MH, Tahmasbi AM, Ghaffari MH, Naserian AA, Valizadeh R, Ghaffari AH. Effects of saponins on rumen fermentation, nutrients digestibility, performance, and plasma metabolites in sheep and goat kids. Annu Res Rev Biol 2013;3:596-607. 
  84. Adegbeye MJ, Elghandour MMMY, Monroy JC, et al. Potential influence of Yucca extract as feed additive on greenhouse gases emission for a cleaner livestock and aquaculture farming - A review. J Cleaner Prod 2019;239:118074. https://doi.org/10.1016/j.jclepro.2019.118074 
  85. Amber KH, Yakout HM, Hamed Rawya S. Effect of feeding diets containing yucca extract or probiotic on growth digestibility nitrogen balance and caecal microbial activity of growing New Zealand White rabbits. In: Proceedings the 8th World Rabbit Congress; Puebla, Mexico; 2004. pp. 737-45. 
  86. Stochmal'ova A, Foldesiova M, Balazi A, et al. Yucca schidigera extract can promote rabbit fecundity and ovarian progesterone release. Theriogenology. 2015:84:634-8. https://doi.org/10.1016/j.theriogenology.2015.04.024 
  87. Bergero D, Zoccarato L, Tartari E, Sarra C. Effects of dietary inclusion of Yucca schidigera extract or phillipsite tuff on digestibility and performances of growing rabbits. World Rabbit Sci 1995;3:187-90. https://doi.org/10.4995/wrs.1995.261 
  88. Sa AEL, AM T, Ham E, Helpawy ES. Inclusion of phytogenic feed additives in diet of growing rabbits: effects on antioxidant enzymes and immunoglobulins. Biomed J Sci Tech Res 2021;33:25499-503. https://doi.org/10.26717/BJSTR.2021.33.005341 
  89. Soltan YA, Morsy AS, Sallam S MA, Hashem NM, Abdalla AL. Propolis as a natural feed additive in ruminant diets; can propolis affect the ruminants performance?: A review. Egypt J Nutr Feeds 2016;19:73-9.  https://doi.org/10.21608/ejnf.2016.74870
  90. Yumnam R, Nandan N Kumar N, Raj S, Mannepalli A. Effect of propolis in oral health. J Ayurveda Integr Med Sci 2017;:186-92. 
  91. Anjum SI, Ullah A, Khan KA, et al. Composition and functional properties of propolis (bee glue): A review. Saudi J Biol Sci 2019;26:1695-703. https://doi.org/10.1016/j.sjbs.2018.08.013 
  92. Shedeed HA, Farrag B, Elwakeel EA, Abd El-Hamid IS, El-Rayes MAH. Propolis supplementation improved productivity, oxidative status, and immune response of Barki ewes and lambs. Vet World 2019;12:834-43. https://doi.org/10.14202/vetworld.2019.834-843 
  93. Burdock GA. Review of the biological properties and toxicity of bee propolis (Propolis). Food Chem Toxicol 1998;36:347-63. https://doi.org/10.1016/S0278-6915(97)00145-2 
  94. Siheri W, Alenezi S, Tusiimire J, Watson DG. The chemical and biological properties of propolis. In: Alvarez-Suarez, editor. Bee products - chemical and biological properties. Springer International Publishing AG; 2017. https://doi.org/10.1007/978-3-319-59689-1-7 
  95. Moraes GV, Mataveli M, Moura LPP, Scapinello C, Mora F, Osmari MP. Inclusion of propolis in rabbits diets and semen characteristics. Arq Cienc Vet Zool UNIPAR Umuarama 2014;17:227-31. out/dez 2014. https://doi.org/1025110/arqvetv17i420145021  1025110/arqvetv17i420145021
  96. Gabr Sh A, Younan GE, Hamad ME, Rehab SA Ismail Mervat Sh M Zaky. Effect of some natural antioxidants on growth performance, blood parameters and carcass traits of growing rabbits under egyptian summer condition. J Anim Poult Prod 2016;7:457-66.  https://doi.org/10.21608/jappmu.2016.48755
  97. Piza PC, Moreira BL, Silva NC, Sodre PI, Fonseca LS, Leite RF. Effect of crude propolis on the performance and feed digestibility of New Zealand White rabbits. Acta Sci Anim Sci 2021;43:e52593. https://doi.org/10.4025/actascianimsci.v43i1.52593 
  98. Bankova VS, de Castro SL, Marcucci MC. Propolis: recent advances in chemistry and plant origin. Apidologie 2000;31:3-15. https://doi.org/10.1051/apido:2000102 
  99. Chan GC, Cheung K, Sze DM. the immunomodulatory and anticancer properties of propolis. Clin Rev Allergy Immunol 2013;44:262-73. https://doi.org/10.1007/s12016-012-8322-2 
  100. Ferreira JM, Silva CF, Salatino A, Negri G, Message D. New propolis type from north-east Brazil: chemical composition, antioxidant activity and botanical origin. J Sci Food Agric 2017;97:3552-8. https://doi.org/10.1002/jsfa.8210 
  101. Awale S, Li F, Onozuka H, Esumi H, Tezukaa Y, Kadotaa S. Constituents of Brazilian red propolis and their preferential cytotoxic activity against human pancreatic PANC-1 cancer cell line in nutrient-deprived condition. Bioorg Med Chem 2008;16:181-9. https://doi.org/10.1016/j.bmc.2007.10.004 
  102. Bankova V. Chemical diversity of propolis and the problem of standardization. J Ethnopharmacol 2005;100:114-7. https://doi.org/10.1016/j.jep.2005.05.004 
  103. Kamel KI, El-Hanoun AM, El-Sbeiy MS, Gad HAM. Effect of bee propolis extract (bee glue) on some productive reproductive and physiological traits of rabbits does and their progenys. The 5th International Conference on Rabbit Production in Hot Climates; Hurghada Egypt; 2007. pp.403-15. 
  104. Wagh VD. Propolis: A wonder bees product and its pharmacological potentials. Adv Pharmacol Pharm Sci 2013;2013:308249. https://doi.org/10.1155/2013/308249 
  105. Bayrami M, khakpoor M, Safavi E, Bayrami A. Medicinal effects of propolis diet on biochemicals and histological factors in rats. Trends Med 2019;19:1-5.  https://doi.org/10.15761/TiM.1000213
  106. Hassan SH, Al-Saadi MAK. Study the bactericidal activity of Propolis in rabbit model. J Phys Conf Ser 2019;1294:062010. https://doi.org/10.1088/1742-6596/1294/6/062010 
  107. Dogan M, Silici S, Ozcimen AA. Biological effects of propolis on cancer. Turkish J Agric Food Sci Technol 2020;8:573-9. https://doi.org/10.24925/turjaf.v8i3.573-579.2939 
  108. Abdelrazeg S, Hussin H, Salih M, Shaharuddin B. Propolis composition and applications in medicine and health. Int Med J 2020;25:1505-42. 
  109. Attia YA, El-Hanoun AM, Bovera F, Monastra G, El-Tahawy WS, Habiba HI. Growth performance, carcass quality, biochemical and haematological traits and immune response of growing rabbits as affected by different growth promoters. J Anim Physiol Anim Nutr 2014;98:128-39. https://doi.org/10.1111/jpn.12056 
  110. Itavo CCBF, Morais MG, Costa C, et al. Addition of propolis or monensin in the diet: Behavior and productivity of lambs in feedlot. Anim Feed Sci Technol 2011;65:161-6. https://doi. org/10.1016/j.anifeedsci.2011.02.020 
  111. Majiene D, Trumbeckelte S, Grunoviene D, Ivanauskas L, Gendrolis A. Investigation of chemical composition of propolis extract. Medicina (Kaunas) 2004;40:771-4. 
  112. Daugsch A, Moraes CS, Fort P, Park YK. Brazilian red propolis: Chemical composition and botanical origin advance access. Publication Evid Based Complement Alternat Med 2008;5:435-41. https://doi.org/10.1093/ecam/nem057 
  113. Suleiman JB, Bakar ABA, Mohamed M. Review on bee products as potential protective and therapeutic agents in male reproductive impairment. Molecules 2021;26:3421. https://doi.org/10.3390/molecules26113421 
  114. Araujo MAR, Liberio SA, Guerra RNM, Ribeiro MNS, Nascimento FRF. Mechanisms of action underlying the anti-inflammatory and immunomodulatory effects of propolis: a brief review. Rev Bras Farmacogn 2012;22:208-19. https://doi.org/10.1590/S0102-695X2011005000167 
  115. Sforcin JM. Propolis and the immune system: a review. J Ethnopharmacol 2007;113:1-14. https://doi.org/10.1016/jjep200705012 
  116. Hashem NM, Abd El-Hady AM, Hassan OA. Inclusion of phytogenic feed additives comparable to vitamin E in diet of growing rabbits: Effects on metabolism and growth. Ann Agric Sci 2017;62:161-7. https://doi.org/10.1016/j.aoas.2017.11.003 
  117. Mona SI, Naglaa AA, Ismail M. Effect of propolis on the immune response and meat quality in experimentally escherichia coli infected broilers. Assiut Vet Med J 2021;67:101-35.  https://doi.org/10.21608/avmj.2021.188829
  118. Attia YA, Bovera F, EL-Tahawy WS, EL-Hanoun AM, AL-Harthi MA, Habiba HI. Productive and reproductive performance of rabbits does as affected by bee pollen and/or propolis, inulin and/or mannan-oligosaccharides. World Rabbit Sci 2015;23:273-82. https://doi.org/10.4995/wrs.2015.3644 
  119. Kupczynski R, Piasecki T, Bednarski M, Spitalniak K, BudnyWalczak A. Application of herbs and propolis in rabbits with chronic diarrhea. Turkish J Vet Anim Sci 2016;40:344-51. https://doi.org/10.3906/vet-1506-12 
  120. Coloni RD, Lui JF, dos Santos E, et al. Effect of propolis alcohol extract on the weight gain carcass traits and cecal pH of growing rabbits. Biotemas 2007;20:59-64. 
  121. Nassar SA, Amira H Mohamed Hamdy Soufy Soad M Nasr Mahran KM. Immunostimulant effect of egyptian propolis in rabbits. Sci World J 2012;2012:901516. https://doi.org/10.1100/2012/901516 
  122. Eiben CS, Gippert T, Godor-Surmann K, Kustos K. Feed additives as they affect the fattening performance of rabbits. 9th World Rabbit Congress; 2008 June 10-13; Verona, Italy. 
  123. Oliveira MC, Ferreira LO, Souza IJG, et al. Supplementation with green propolis extract in rations for growing rabbits. Rev Electron Vet 2018;19:031839. 
  124. El-Hanoun AM, Kamel KI, El-Sebaei MS, Gad HAM. Effect of Egyptian propolis supplementation on productive reproductive performance and some hematobiochemical parameters and steroid hormones of female rabbits during winter and summer seasons. In Proc: 4th World Poultry Conference; 27-30 March 2007; Sharm El-Sheikh Egypt. pp. 417-23. 
  125. Hadi AA. Study the Effect of Iraqi propolis extract on hematological parameters in alloxan-induced diabetic rabbits mirror. Res Vet Sci Anim 2019;3:1-10. 
  126. Orsolic N, Basic I. Immunomodulation by water-soluble derivative of propolis: a factor of antitumor reactivity. J Ethnopharmacol 2003;84:265-73. https://doi.org/10.1016/S0378-8741(02)00329-X 
  127. Park YK, Paredes-Guzman JF, Aguiar C, Alencar SM, Fred Y, Fujiwara FY. Chemical constituents in baccharis dracunculifolia as the main botanical origin of southeastern Brazilian propolis. J Agric Food Chem 2004;52:1100-3. https://doi.org/10.1021/jf021060m 
  128. Braakhuis A. Evidence on the health benefits of supplemental propolis. Nutrients 2019;11:2705. https://doi.org/10.3390/nu11112705