Journal of the Korean Society of Visualization (한국가시화정보학회지)

The Korean Society of Visualization (한국가시화정보학회)
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4D flow MRI based flow visualization and quantification of bicuspid valvular flow using ex-vivo porcine model

4차원 자기공명영상을 활용한 돼지 심장 ex-vivo 이첨판 모델 유동 가시화 및 유동 특성 분석

  • Minseong Kwon (Division of Biomedical Engineering, University of Ulsan) ;
  • Sungho Park (Medical Device Development Center, Daegu Gyeongbuk Medical Innovation Foundation) ;
  • Hyungkyu Huh (Medical Device Development Center, Daegu Gyeongbuk Medical Innovation Foundation)
  • 권민성 ;
  • 박성호 ;
  • 허형규
  • Received : 2022.10.21
  • Accepted : 2023.01.14
  • Published : 2023.03.31
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Abstract

Aortic valve stenosis is a heart valve disease caused by the accumulation of calcium in the valve, which can divide into tricuspid aortic valve (TAV) stenosis and bicuspid aortic valve (BAV) stenosis depending on the shape of natural valve. In this study, pig heart-based TAV and BAV ex vivo models were fabricated, and the flow characteristics behind a valve were analyzed using 4D flow MRI. Flow behind normal TAV was uniformly distributed, while BAV asymmetrically opened with an eccentric strong jet. Especially, BAV ex vivo model exhibited a secondary flow in the region where the valve closed. In addition, BAV had a 26% higher peak velocity while maintaining similar stroke volume compared with normal TAV. This study would be helpful for understanding the flow characteristics for BAV AS patients.

Keywords

Acknowledgement

본 연구는 과학기술정보통신부 및 대구경북첨단의료산업진흥재단의 재원으로 한국연구재단 및 '2023 KMEDI hub 자체연구사업'의 지원에 의하여 이루어진 것임. (NRF-2021R1C1C1003481 / B-C-N-22-06)

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