대한본초학회지 (The Korea Journal of Herbology)

  • 제38권3호
  • /
  • Pages.1-10
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  • 2023
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  • 1229-1765(pISSN)
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  • 2288-7199(eISSN)
대한본초학회 (The Korea Association of Herbology)
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몽골산 약용식물 수종의 항비만 활성 탐색을 위한 기초 연구

Basic research for exploring anti-obesity activity of several medicinal plants from Mongolia

  • 최문열 (대구한의대 한의과대학 본초약리학교실) ;
  • 김소영 (대구한의대 한의과대학 본초약리학교실) ;
  • 김미려 (대구한의대 한의과대학 본초약리학교실)
  • Moon-Yeol Choi (Department of Herbal Pharmacology, College of Korean Medicine, Daegu Haany University) ;
  • So-Young Kim (Department of Herbal Pharmacology, College of Korean Medicine, Daegu Haany University) ;
  • Mi Ryeo Kim (Department of Herbal Pharmacology, College of Korean Medicine, Daegu Haany University)
  • 투고 : 2023.04.10
  • 심사 : 2023.05.25
  • 발행 : 2023.05.30
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초록

Objective : Obesity in modern society has a significant impact on pathological, psychological and social problems. Therefore, many studies on obesity treatment using herbal extracts with fewer side effects have been conducted. This study was designed to investigate the effect of inhibiting fat accumulation in vitro in order to Mongolian medicinal plants find anti-obesity candidate among. Methods : We measured pancreatic lipase inhibitory activity in Mongolian medicinal plants extract. Cytotoxicity of these extracts was monitored in 3T3-L1 cells by MTT assay. In addition, the anti-obesity effects was confirmed at concentrations of 0.2, 0.1 and 0.05 mg/㎖ through Oil red O staining. Results : Among Mongolian medicinal plants, Rheum undulatum roots in September (RURS), Paeonia anomala L. (PAL), and Fragaria orientalis (FO) showed the highest pancreatic lipase inhibitory activity. As a result of the MTT assay, more than 80% was judged to be non-toxic, and the concentration was determined, and as a result of evaluating the lipid accumulation inhibitory effect, 6 types were selected as candidates. Conclusion : Based on these results, the top 7 species expected to be used as anti-obesity functional materials were selected. However, additional efficacy verification and mechanism of action need to be established in the future. So, it is expected that the medicinal plants verified through this will be used as functional materials for the prevention and treatment of obesity.

키워드

과제정보

이 논문은 농촌진흥청 (No. PJ015272032022)과 한국연구재단 (No. 2021R1A2C201471711)의 지원을 받아 수행된 연구입니다 (No. PJ015272032022).

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