Pediatric Gastroenterology, Hepatology & Nutrition

The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition (대한소아소화기영양학회)
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Fecal Calprotectin Levels Significantly Correlate with Polyp Size in Children and Adolescents with Juvenile Colorectal Polyps

  • Yu Bin Kim (Department of Pediatrics, Ajou University School of Medicine) ;
  • Ju Young Kim (Department of Pediatrics, Eulji University Hospital) ;
  • Sujin Choi (Department of Pediatrics, School of Medicine, Kyunpook National University) ;
  • Yoo Min Lee (Department of Pediatrics, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine) ;
  • So Yoon Choi (Department of Pediatrics, Kosin University Gospel Hospital, Kosin University College of Medicine) ;
  • Soon Chul Kim (Department of Pediatrics, Jeonbuk National University Medical School and Hospital) ;
  • Hyo-Jeong Jang (Department of Pediatrics, Keimyung University School of Medicine, Dongsan Medical Center) ;
  • Yoon Lee (Department of Pediatrics, Korea University Anam Hospital) ;
  • In Sook Jeong (Department of Pediatrics, Chung-Ang University Gwangmyeong Hospital) ;
  • Dae Yong Yi (Department of Pediatrics, Chung-Ang University Hospital, College of Medicine, Chung-Ang University) ;
  • Yunkoo Kang (Department of Pediatrics, Yonsei University Wonju College of Medicine) ;
  • Kyung Jae Lee (Department of Pediatrics, Hallym University College of Medicine) ;
  • Byung-Ho Choe (Department of Pediatrics, School of Medicine, Kyunpook National University) ;
  • Ben Kang (Department of Pediatrics, School of Medicine, Kyunpook National University)
  • Received : 2021.12.30
  • Accepted : 2022.08.30
  • Published : 2023.01.15
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Abstract

Purpose: We aimed to investigate factors that correlate with fecal calprotectin (FC) levels in children and adolescents with colorectal polyps. Methods: Pediatric patients aged <19 years who underwent colonoscopic polypectomy for a juvenile polyps (JPs) and FC tests were simultaneously conducted in a multicenter, retrospective study. Baseline demographics, colonoscopic and histological findings, and laboratory tests, including FC levels, were investigated. Correlations between the factors were investigated, and linear regression analysis revealed factors that correlated with FC levels. FC levels measured after polypectomies were investigated and the FC levels pre- and post-polypectomies were compared. Results: A total of 33 patients were included in the study. According to Pearson correlation analysis, the polyp size was the only factor that showed a statistically significant correlation with FC levels (r=0.75, p<0.001). Furthermore, according to the multivariate linear regression analysis, polyp size was the only factor that showed a statistically significant correlation with FC levels (adjusted R2=0.5718, β=73.62, p<0.001). The median FC level was 400 mg/kg (interquartile range [IQR], 141.6-1,000 mg/kg), and the median polyp size was 14 mm (IQR, 9-20 mm). Nineteen patients underwent post-polypectomy FC tests. FC levels showed a significant decrease after polypectomy from a median of 445.2 mg/kg (IQR, 225-1,000) to 26.5 mg/kg (11.5-51) (p<0.001). Conclusion: FC levels significantly correlated with polyp size in children and adolescents with JPs.

Keywords

Acknowledgement

This work was supported by the National Research Foundation of Korea (NRF) grant, funded by the Korean government (MSIT) (No. 2021R1A2C1011004).

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