Animal Bioscience

Asian Australasian Association of Animal Production Societies (아세아태평양축산학회)
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Role of antioxidants in fertility preservation of sperm - A narrative review

  • Ahmad Yar Qamar (College of Veterinary and Animal Sciences, Sub-campus of University of Veterinary and Animal Science) ;
  • Muhammad Ilyas Naveed (College of Veterinary and Animal Sciences, Sub-campus of University of Veterinary and Animal Science) ;
  • Sanan Raza (College of Veterinary and Animal Sciences, Sub-campus of University of Veterinary and Animal Science) ;
  • Xun Fang (Laboratory of Theriogenology, College of Veterinary Medicine, Chungnam National University) ;
  • Pantu Kumar Roy (Laboratory of Theriogenology, College of Veterinary Medicine, Chungnam National University) ;
  • Seonggyu Bang (Laboratory of Theriogenology, College of Veterinary Medicine, Chungnam National University) ;
  • Bereket Molla Tanga (Laboratory of Theriogenology, College of Veterinary Medicine, Chungnam National University) ;
  • Islam M. Saadeldin (Laboratory of Theriogenology, College of Veterinary Medicine, Chungnam National University) ;
  • Sanghoon Lee (Laboratory of Theriogenology, College of Veterinary Medicine, Chungnam National University) ;
  • Jongki Cho (Laboratory of Theriogenology, College of Veterinary Medicine, Chungnam National University)
  • Received : 2022.08.29
  • Accepted : 2022.11.07
  • Published : 2023.03.01
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Abstract

Male fertility is affected by multiple endogenous stressors, including reactive oxygen species (ROS), which greatly deteriorate the fertility. However, physiological levels of ROS are required by sperm for the proper accomplishment of different cellular functions including proliferation, maturation, capacitation, acrosomal reaction, and fertilization. Excessive ROS production creates an imbalance between ROS production and neutralization resulting in oxidative stress (OS). OS causes male infertility by impairing sperm functions including reduced motility, deoxyribonucleic acid damage, morphological defects, and enhanced apoptosis. Several in-vivo and in-vitro studies have reported improvement in quality-related parameters of sperm following the use of different natural and synthetic antioxidants. In this review, we focus on the causes of OS, ROS production sources, mechanisms responsible for sperm damage, and the role of antioxidants in preserving sperm fertility.

Keywords

Acknowledgement

We would like to acknowledge all members of our research team for their sincere contributions and the funding agency for their financial support.

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