Journal of Yeungnam Medical Science

Yeungnam University College of Medicine, Yeungnam University Institute Medical Science (영남대 의대 학술지 편집위원회)
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Intravesical bacillus Calmette-Guérin-induced myopathy presenting as rhabdomyolysis: a case report

  • Chae Hun Lee (Yonsei University College of Medicine) ;
  • Byeong Joo Choi (Department of Neurology, Yonsei University College of Medicine) ;
  • Jung Hun Kim (Yonsei University College of Medicine) ;
  • Tae Woong Yang (Yonsei University College of Medicine) ;
  • Gi Jeong Kim (Department of Pathology, Yonsei University College of Medicine) ;
  • Ha Young Shin (Department of Neurology, Yonsei University College of Medicine) ;
  • Se Hoon Kim (Department of Pathology, Yonsei University College of Medicine) ;
  • Seung Woo Kim (Department of Neurology, Yonsei University College of Medicine)
  • Received : 2022.11.04
  • Accepted : 2022.12.28
  • Published : 2023.10.31
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Abstract

Intravesical bacillus Calmette-Guérin (BCG) instillation is an adjuvant treatment for non-muscle-invasive urinary bladder cancer. Although most complications associated with BCG immunotherapy are mild and self-limiting, rare albeit serious complications have been reported. Only a few cases of BCG-related rhabdomyolysis have been reported. In this study, we present the case of a 72-year-old woman who developed severe weakness and hyperCKemia following intravesical BCG instillation. A muscle biopsy was performed, and a diagnosis of drug-induced myopathy was made.

Keywords

Acknowledgement

This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIP) (2019R1C1C1009875).

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