East Asian mathematical journal

  • 제39권1호
  • /
  • Pages.65-73
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  • 2023
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  • 1226-6973(pISSN)
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  • 2287-2833(eISSN)
영남수학회 (The Youngnam Mathematical Society)
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REGULATION OF β-CATENIN IN THE WNT SIGNALING PATHWAY AND EMT VIA OPTIMAL CONTROL

  • Sooyoun, Choi (Department of Mathematics, Pusan National University) ;
  • Il Hyo, Jung (Department of Mathematics, Pusan National University)
  • 투고 : 2023.01.16
  • 심사 : 2023.01.26
  • 발행 : 2023.01.31
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초록

In this paper, we present an optimal control strategy to prevent the EMT process by downregulating the level of overexpressed β-catenin in the cytoplasm. To do this, we propose a mathematical model that expresses relationship between the Wnt signaling pathway and TGF-β in cancer cells. We also define an optimal control problem considering the side effects that occur simultaneously with the method for controlling the concentration of β-catenin. Finally numerical simulations show that treatment effect is quantitatively changes depending on the concentration of core proteins of the Wnt signaling pathway.

키워드

과제정보

This work was supported by a 2-Year Research Grant of Pusan National University.

참고문헌

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