과제정보
The authors would like to thank Prof. Dr. dr. Ismail Hadisoebroto Dilogo, Sp.OT(K) for his support and advice during the research.
참고문헌
- Kwon BK, Bloom O, Wanner IB, Curt A, Schwab JM, Fawcett J, et al. Neurochemical biomarkers in spinal cord injury. Spinal Cord 2019; 57: 819-31. https://doi.org/10.1038/s41393-019-0319-8
- Miranpuri GS, Nguyen J, Moreno N, Yutuc NA, Kim J, Buttar S, et al. Folic acid modulates matrix metalloproteinase-9 expression following spinal cord injury. Ann Neurosci 2019; 26: 60-5. https://doi.org/10.5214/ans.0972.7531.260205
- Hagen EM, Rekand T. Management of neuropathic pain associated with spinal cord injury. Pain Ther 2015; 4: 51-65. https://doi.org/10.1007/s40122-015-0033-y
- Davari M, Amani B, Amani B, Khanijahani A, Akbarzadeh A, Shabestan R. Pregabalin and gabapentin in neuropathic pain management after spinal cord injury: a systematic review and meta-analysis. Korean J Pain 2020; 33: 3-12. https://doi.org/10.3344/kjp.2020.33.1.3
- Liau LL, Looi QH, Chia WC, Subramaniam T, Ng MH, Law JX. Treatment of spinal cord injury with mesenchymal stem cells. Cell Biosci 2020; 10: 112. https://doi.org/10.1186/s13578-020-00475-3
- Fakhri S, Sabouri S, Kiani A, Farzaei MH, Rashidi K, Mohammadi-Farani A, et al. Intrathecal administration of naringenin improves motor dysfunction and neuropathic pain following compression spinal cord injury in rats: relevance to its antioxidant and anti-inflammatory activities. Korean J Pain 2022; 35: 291-302. https://doi.org/10.3344/kjp.2022.35.3.291
- Assinck P, Duncan GJ, Hilton BJ, Plemel JR, Tetzlaff W. Cell transplantation therapy for spinal cord injury. Nat Neurosci 2017; 20: 637-47. https://doi.org/10.1038/nn.4541
- Pajer K, Bellak T, Nogradi A. Stem cell secretome for spinal cord repair: is it more than just a random baseline set of factors? Cells 2021; 10: 3214. https://doi.org/10.3390/cells10113214
- Sabelstrom H, Stenudd M, Reu P, Dias DO, Elfineh M, Zdunek S, et al. Resident neural stem cells restrict tissue damage and neuronal loss after spinal cord injury in mice. Science 2013; 342: 637-40. https://doi.org/10.1126/science.1242576
- Dilogo IH, Fiolin J. Role of mesenchymal stem cell-conditioned medium (MSC-CM) in the bone regeneration: a systematic review from 2007-2018. Annu Res Rev Biol 2019; 31: 1-16. https://doi.org/10.9734/arrb/2019/v31i230045
- Cunningham CJ, Redondo-Castro E, Allan SM. The therapeutic potential of the mesenchymal stem cell secretome in ischaemic stroke. J Cereb Blood Flow Metab 2018; 38: 1276-92. https://doi.org/10.1177/0271678X18776802
- Zhou J, Ni W, Ling Y, Lv X, Niu D, Zeng Y, et al. Human neural stem cell secretome inhibits lipopolysaccharide-induced neuroinflammation through modulating microglia polarization by activating peroxisome proliferator-activated receptor gamma. Stem Cells Dev 2022; 31: 369-82. https://doi.org/10.1089/scd.2022.0081
- Mercan A, Uzun ST, Keles S, Hacibeyoglu G, Yilmaz R, Reisli R. Immunological mechanism of postherpetic neuralgia and effect of pregabalin treatment on the mechanism: a prospective single-arm observational study. Korean J Pain 2021; 34: 463-70. https://doi.org/10.3344/kjp.2021.34.4.463
- Gao L, Peng Y, Xu W, He P, Li T, Lu X, et al. Progress in stem cell therapy for spinal cord injury. Stem Cells Int 2020; 2020: 2853650. https://doi.org/10.1155/2020/2853650
- Haider T, Hoftberger R, Ruger B, Mildner M, Blumer R, Mitterbauer A, et al. The secretome of apoptotic human peripheral blood mononuclear cells attenuates secondary damage following spinal cord injury in rats. Exp Neurol 2015; 267: 230-42. https://doi.org/10.1016/j.expneurol.2015.03.013
- Oliveri RS, Bello S, Biering-Sorensen F. Mesenchymal stem cells improve locomotor recovery in traumatic spinal cord injury: systematic review with meta-analyses of rat models. Neurobiol Dis 2014; 62: 338-53. https://doi.org/10.1016/j.nbd.2013.10.014
- Swenson J, Carpenter JW. Select topics for the exotic animal veterinarian. In: Exotic Animal Formulary. 5th ed. Edited by Carpenter JW, Marion CJ. St. Louis, Saunders. 2018, pp 636-63.
- George RP, Howarth GS, Whittaker AL. Use of the rat grimace scale to evaluate visceral pain in a model of chemotherapy-induced mucositis. Animals (Basel) 2019; 9: 678. https://doi.org/10.3390/ani9090678
- Klune CB, Larkin AE, Leung VSY, Pang D. Comparing the Rat Grimace Scale and a composite behaviour score in rats. PLoS One 2019; 14: e0209467. https://doi.org/10.1371/journal.pone.0209467
- Basso DM, Beattie MS, Bresnahan JC. A sensitive and reliable locomotor rating scale for open field testing in rats. J Neurotrauma 1995; 12: 1-21. https://doi.org/10.1089/neu.1995.12.1
- Borhani-Haghighi M, Navid S, Mohamadi Y. The therapeutic potential of conditioned medium from human breast milk stem cells in treating spinal cord injury. Asian Spine J 2020; 14: 131-8. https://doi.org/10.31616/asj.2019.0026
- Carter MW, Johnson KM, Lee JY, Hulsebosch CE, Gwak YS. Comparison of mechanical allodynia and recovery of locomotion and bladder function by different parameters of low thoracic spinal contusion injury in rats. Korean J Pain 2016; 29: 86-95. https://doi.org/10.3344/kjp.2016.29.2.86
- Leung V, Zhang E, Pang DS. Real-time application of the Rat Grimace Scale as a welfare refinement in laboratory rats. Sci Rep 2016; 6: 31667. https://doi.org/10.1038/srep31667
- Wu J, Zhao Z, Zhu X, Renn CL, Dorsey SG, Faden AI. Cell cycle inhibition limits development and maintenance of neuropathic pain following spinal cord injury. Pain 2016; 157: 488-503. https://doi.org/10.1097/j.pain.0000000000000393
- Hatch MN, Cushing TR, Carlson GD, Chang EY. Neuropathic pain and SCI: identification and treatment strategies in the 21st century. J Neurol Sci 2018; 384: 75-83. https://doi.org/10.1016/j.jns.2017.11.018
- Schneider LE, Henley KY, Turner OA , Pat B, Niedzielko TL, Floyd CL. Application of the Rat Grimace Scale as a marker of supraspinal pain sensation after cervical spinal cord injury. J Neurotrauma 2017; 34: 2982-93. https://doi.org/10.1089/neu.2016.4665
- Cunningham CJ, Enrich MV, Pickford MM, MacIntosh-Smith W, Huang W. The therapeutic potential of the stem cell secretome for spinal cord repair: a systematic review and meta-analysis. OBM Neurobiol 2020; 4: 080. https://doi.org/10.21926/obm.neurobiol.2004080
- Mietto BS, Mostacada K, Martinez AM. Neurotrauma and inflammation: CNS and PNS responses. Mediators Inflamm 2015; 2015: 251204. https://doi.org/10.1155/2015/251204
- Owoyele BV, Bakare AO, Olaseinde OF, Ochu MJ, Yusuff AM, Ekebafe F, et al. Synergistic interaction between acetaminophen and L-carnosine improved neuropathic pain via NF-κB pathway and antioxidant properties in chronic constriction injury model. Korean J Pain 2022; 35: 271-9. https://doi.org/10.3344/kjp.2022.35.3.271
- Jia Z, Zhu H, Li J, Wang X, Misra H, Li Y. Oxidative stress in spinal cord injury and antioxidant-based intervention. Spinal Cord 2012; 50: 264-74. https://doi.org/10.1038/sc.2011.111
- Dos Santos MF, Roxo C, Sola S. Oxidative-signaling in neural stem cell-mediated plasticity: implications for neurodegenerative diseases. Antioxidants (Basel) 2021; 10: 1088. https://doi.org/10.3390/antiox10071088
- Giudicessi JR, Ackerman MJ. Determinants of incomplete penetrance and variable expressivity in heritable cardiac arrhythmia syndromes. Transl Res 2013; 161: 1-14. https://doi.org/10.1016/j.trsl.2012.08.005
- Clausen F, Marklund N, Lewen A, Enblad P, Basu S, Hillered L. Interstitial F(2)-isoprostane 8-isoPGF(2α) as a biomarker of oxidative stress after severe human traumatic brain injury. J Neurotrauma 2012; 29: 766-75. https://doi.org/10.1089/neu.2011.1754
- Leung L. Cellular therapies for treating pain associated with spinal cord injury. J Transl Med 2012; 10: 37. https://doi.org/10.1186/1479-5876-10-37
- Cheng Z, Zhu W, Cao K, Wu F, Li J, Wang G, et al. Anti-inflammatory mechanism of neural stem cell transplantation in spinal cord injury. Int J Mol Sci 2016; 17: 1380. https://doi.org/10.3390/ijms17091380
- Li S, Gu X, Yi S. The regulatory effects of transforming growth factor-β on nerve regeneration. Cell Transplant 2017; 26: 381-94. https://doi.org/10.3727/096368916X693824
- Pajer K, Bellak T, Nogradi A. The mutual interaction between the host spinal cord and grafted undifferentiated stem cells fosters the production of a lesion-induced secretome. Neural Regen Res 2020; 15: 1844-5. https://doi.org/10.4103/1673-5374.280312
- Hansen CN, Fisher LC, Deibert RJ, Jakeman LB, Zhang H, Noble-Haeusslein L, et al. Elevated MMP-9 in the lumbar cord early after thoracic spinal cord injury impedes motor relearning in mice. J Neurosci 2013; 33: 13101-11. https://doi.org/10.1523/JNEUROSCI.1576-13.2013
- Gomes LR, Terra LF, Wailemann RA, Labriola L, Sogayar MC. TGF-β1 modulates the homeostasis between MMPs and MMP inhibitors through p38 MAPK and ERK1/2 in highly invasive breast cancer cells. BMC Cancer 2012; 12: 26. https://doi.org/10.1186/1471-2407-12-26
- De Araujo AA, Varela H, Brito GAC, De Medeiros CACX, Araujo LS, Do Nascimento JHO, et al. Azilsartan increases levels of IL-10, down-regulates MMP-2, MMP-9, RANKL/RANK, cathepsin K and up-regulates OPG in an experimental periodontitis model. PLoS One 2014; 9: e96750. https://doi.org/10.1371/journal.pone.0096750
- Lakhan SE, Avramut M. Matrix metalloproteinases in neuropathic pain and migraine: friends, enemies, and therapeutic targets. Pain Res Treat 2012; 2012: 952906. https://doi.org/10.1155/2012/952906
- Anwar MA, Al Shehabi TS, Eid AH. Inflammogenesis of secondary spinal cord injury. Front Cell Neurosci 2016; 10: 98. https://doi.org/10.3389/fncel.2016.00098
- Joko M, Osuka K, Usuda N, Atsuzawa K, Aoyama M, Takayasu M. Different modifications of phosphorylated Smad3C and Smad3L through TGF-β after spinal cord injury in mice. Neurosci Lett 2013; 549: 168-72. https://doi.org/10.1016/j.neulet.2013.05.042
- Shahsavari F, Abbasnejad M, Esmaeili-Mahani S, Raoof M. The ability of orexin-A to modify pain-induced cyclooxygenase-2 and brain-derived neurotrophic factor expression is associated with its ability to inhibit capsaicin-induced pulpal nociception in rats. Korean J Pain 2022; 35: 261-70. https://doi.org/10.3344/kjp.2022.35.3.261
- Weishaupt N, Li S, Di Pardo A, Sipione S, Fouad K. Synergistic effects of BDNF and rehabilitative training on recovery after cervical spinal cord injury. Behav Brain Res 2013; 239: 31-42. https://doi.org/10.1016/j.bbr.2012.10.047
- Leech KA, Hornby TG. High-intensity locomotor exercise increases brain-derived neurotrophic factor in individuals with incomplete spinal cord injury. J Neurotrauma 2017; 34: 1240-8. https://doi.org/10.1089/neu.2016.4532
- Boyce VS, Mendell LM. Neurotrophins and spinal circuit function. Front Neural Circuits 2014; 8: 59. https://doi.org/10.3389/fncir.2014.00059
- Tashiro S, Shinozaki M, Mukaino M, Renault-Mihara F, Toyama Y, Liu M, et al. BDNF induced by treadmill training contributes to the suppression of spasticity and allodynia after spinal cord injury via upregulation of KCC2. Neurorehabil Neural Repair 2015; 29: 677-89. https://doi.org/10.1177/1545968314562110
- Kusiak AN, Selzer ME. Neuroplasticity in the spinal cord. Handb Clin Neurol 2013; 110: 23-42. https://doi.org/10.1016/B978-0-444-52901-5.00003-4
- Anjum A, Yazid MD, Daud MF, Idris J, Hwei Ng AM, Naicker AS, et al. Spinal cord injury: pathophysiology, multimolecular interactions, and underlying recovery mechanisms. Int J Mol Sci 2020; 21: 7533. https://doi.org/10.3390/ijms21207533