Applied Chemistry for Engineering (공업화학)

The Korean Society of Industrial and Engineering Chemistry (한국공업화학회)
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Promotion of 3T3 and HDF Cell Migration by Gelatin-modified Fibroin Microspheres

  • Se Change Kwon (SG Medical) ;
  • Won Hur (Department of Biotech & Bioengineering, Kangwon National University)
  • Received : 2023.02.23
  • Accepted : 2023.03.09
  • Published : 2023.04.10
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Abstract

The goal of this study was to use gelatin to modify the surface of fibroin microspheres to enhance their biofunctionality for tissue engineering and regenerative medicine applications. Three different methods were used for the modification: coating, incorporation, and covalent bonding. Wound-healing assays demonstrated that gelatin modification of fibroin microspheres enhances 3T3 and HDF cell migration. Although the level of gelatin coverage varied depending on the method used, there was no significant difference between the modified microspheres. The gelatin-modified microspheres also increased the migration velocity of individual 3T3 cells. The results suggest that gelatin modification of fibroin microspheres is a promising approach for developing functional biomaterials with enhanced biological properties. Further optimization of gelatin modification is necessary to maximize the biofunctionality of fibroin microspheres.

Keywords

Acknowledgement

This study has been worked with the support of a research grant of Kangwon National University in 2021 and the National Research Foundation of Korea (NRF-2016R1D1A1B01011660).

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