Safety and Health at Work

Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency (산업안전보건연구원)
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Impact of COVID-19 Infection on Work Functioning in Japanese Workers: A Prospective Cohort Study

  • Makoto Okawara (Department of Environmental Epidemiology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health) ;
  • Keiki Hirashima (Department of Environmental Epidemiology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health) ;
  • Yu Igarashi (Disaster Occupational Health Center, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health) ;
  • Kosuke Mafune (Department of Mental Health, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health) ;
  • Keiji Muramatsu (Department of Preventive Medicine and Community Health, School of Medicine, University of Occupational and Environmental Health) ;
  • Tomohisa Nagata (Department of Occupational Health Practice and Management, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health) ;
  • Mayumi Tsuji (Department of Environmental Health, School of Medicine, University of Occupational and Environmental Health) ;
  • Akira Ogami (Department of Work Systems and Health, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health) ;
  • Yoshihisa Fujino (Department of Environmental Epidemiology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health)
  • Received : 2023.07.11
  • Accepted : 2023.10.03
  • Published : 2023.12.30
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Abstract

Background: The impact of COVID-19 infection on workers' work function persists even after the acute phase of the infection. We studied this phenomenon in Japanese workers. Methods: We conducted a one-year prospective cohort study online, starting with a baseline survey in December 2020. We tracked workers without baseline work functioning impairment and incorporated data from 14,421 eligible individuals into the analysis. We estimated the incidence rate ratio for new onset of work functioning impairment due to COVID-19 infection during follow-up, using mixed-effects Poisson regression analysis with robust variance. Results: Participants reporting infection between January and December 2021 showed a significantly higher incidence of new work functioning impairment (adjusted incidence rate ratio: 2.18, 95% confidence interval: 1.75-2.71, p < 0.001). The formality of the recuperation environment correlated with a higher risk of work functioning deterioration in infected individuals (p for trend <0.001). Conclusion: COVID-19-infected workers may continue to experience work difficulties due to persistent, post-acute infection symptoms. Companies and society must urgently provide rehabilitation and social support for people with persistent symptoms, recognizing that COVID-19 is not just a transient acute infection.

Keywords

Acknowledgement

The current members of the CORoNaWork Project, in alphabetical order, are as follows: Dr. Akira Ogami, Dr. Ayako Hino, Dr. Hajime Ando, Dr. Hisashi Eguchi, Dr. Keiji Muramatsu, Dr. Koji Mori, Dr. Kosuke Mafune, Dr. Makoto Okawara, Dr. Mami Kuwamura, Dr. Mayumi Tsuji, Dr. Ryutaro Matsugaki, Dr. Seiichiro Tateishi, Dr. Shinya Matsuda, Dr. Tomohiro Ishimaru, and Dr. Tomohisa Nagata, Dr. Yoshihisa Fujino (present chairperson of the study group), and Dr. Yu Igarashi. All members are affiliated with the University of Occupational and Environmental Health, Japan.

References

  1. Coronavirus Disease (COVID-19) Situation Reports [Internet]. [cited 2023 Jun 2]. Available from: https://www.who.int/emergencies/diseases/novel-coronavirus2019/situation-reports.
  2. Statement on the fifteenth meeting of the IHR (2005) Emergency Committee on the COVID-19 pandemic [Internet]. [cited 2023 Jun 2]. Available from: https://www.who.int/news/item/05-05-2023-statement-on-the-fifteenthmeeting-of-the-international-health-regulations-(2005)-emergency-committee-regarding-the-coronavirus-disease-(covid-19)-pandemic.
  3. Soriano JB, Murthy S, Marshall JC, Relan P, Diaz JV. WHO clinical case definition working group on post-COVID-19 condition. A clinical case definition of post-COVID-19 condition by a Delphi consensus. Lancet Infect Dis 2022 Apr;22(4):e102-7.
  4. Crook H, Raza S, Nowell J, Young M, Edison P. Long covid-mechanisms, risk factors, and management. BMJ 2021 Jul 26;374:n1648.
  5. Samper-Pardo M, Olivan-Blazquez B, Magallon-Botaya R, Mendez-Lopez F, Bartolome-Moreno C, Leon-Herrera S. The emotional well-being of Long COVID patients in relation to their symptoms, social support and stigmatization in social and health services: a qualitative study. BMC Psychiatry 2023 Jan 25;23(1):68.
  6. Centers for Disease Control and Prevention. What is Long COVID [Internet]. Centers Dis Control Prev Website. [cited 2023 Jun 2]. Available from: https://www.covid.gov/longcovid/definitions.
  7. Brown DA, O'Brien KK. Conceptualising Long COVID as an episodic health condition. BMJ Glob Health [Internet] 2021 Sep;6(9). https://doi.org/10.1136/bmjgh-2021-007004.
  8. Walker S, Goodfellow H, Pookarnjanamorakot P, Murray E, Bindman J, Blandford A, Bradbury K, Cooper B, Hamilton FL, Hurst JR, Hylton H, Linke S, Pfeffer P, Ricketts W, Robson C, Stevenson FA, Sunkersing D, Wang J, Gomes M, Henly W, Collaboration LWCR. Impact of fatigue as the primary determinant of functional limitations among patients with post-COVID-19 syndrome: a cross-sectional observational study. BMJ Open 2023 Jun 7;13(6):e069217.
  9. Nandasena HMRKG, Pathirathna ML, Atapattu AMMP, Prasanga PTS. Quality of life of COVID 19 patients after discharge: systematic review. PLoS One 2022 Feb 16;17(2):e0263941.
  10. Frontera JA, Yang D, Lewis A, Patel P, Medicherla C, Arena V, Fang T, Andino A, Snyder T, Madhavan M, Gratch D, Fuchs B, Dessy A, Canizares M, Jauregui R, Thomas B, Bauman K, Olivera A, Bhagat D, Sonson M, Park G, Stainman R, Sunwoo B, Talmasov D, Tamimi M, Zhu Y, Rosenthal J, Dygert L, Ristic M, Ishii H, Valdes E, Omari M, Gurin L, Huang J, Czeisler BM, Kahn DE, Zhou T, Lin J, Lord AS, Melmed K, Meropol S, Troxel AB, Petkova E, Wisniewski T, Balcer L, Morrison C, Yaghi S, Galetta S. A prospective study of long-term outcomes among hospitalized COVID-19 patients with and without neurological complications. J Neurol Sci 2021 Jul 15;426:117486.
  11. Tempany M, Leonard A, Prior AR, Boran G, Reilly P, Murray C, O'Brien M, Maguire G, Ennis D, Rakovac A, Reid A. The potential impact of post-COVID symptoms in the healthcare sector. Occup Med 2021 Oct 1;71(6-7):284-9.
  12. Gaber TA-ZK, Ashish A, Unsworth A. Persistent post-covid symptoms in healthcare workers. Occup Med 2021 Jun 16;71(3):144-6.
  13. Lunt J, Hemming S, Burton K, Elander J, Baraniak A. What workers can tell us about post-COVID workability. Occup Med [Internet] 2022 Aug 15. https://doi.org/10.1093/occmed/kqac086 kqac086.
  14. Babnik K, Staresinic C, Lep Z. Some of the workforce face post COVID after the acute phase of the illness: the employer's supportive role. Hum Syst Manage 2022 Apr 11;41(2):257-75.
  15. Gallegos M, Morgan ML, Burgos-Videla C, Caycho-Rodriguez T, Martino P, Cervigni M. The impact of long Covid on people's capacity to work. Ann Work Expo Health 2023 Aug 9;67(7):801-4. https://doi.org/10.1093/annweh/wxad029.
  16. Nagata T, Mori K, Ohtani M, Nagata M, Kajiki S, Fujino Y, Matsuda S, Loeppke R. Total health-related costs due to absenteeism, presenteeism, and medical and pharmaceutical expenses in Japanese employers. J Occup Environ Med 2018 May;60(5):e273-e280.
  17. Fujino Y, Ishimaru T, Eguchi H, Tsuji M, Tateishi S, Ogami A, Mori K, Matsuda S. Protocol for a nationwide internet-based health survey of workers during the COVID-19 pandemic in 2020. J UOEH 2021;43(2):217-25.
  18. Fujino Y, Uehara M, Izumi H, Nagata T, Muramatsu K, Kubo Oyama I, Matsuda S. Development and validity of a work functioning impairment scale based on the Rasch model among Japanese workers. J Occup Health 2015 Sep 4;57(6):521-31.
  19. Makishima M, Fujino Y, Kubo T, Izumi H, Uehara M, Oyama I, Matsuda S. Validity and responsiveness of the work functioning impairment scale (WFun) in workers with pain due to musculoskeletal disorders. J Occup Health 2018 Mar 27;60(2):156-62.
  20. Tokutsu K, Kawazoe S, Katsuki A, Muramatsu K, Makishima M, Kubo T, Yoshimura R, Matsuda S, Fujino Y. Validity and responsiveness of the work functioning impairment scale in workers with depression. J Occup Environ Med 2019 Dec;61(12):e523-7.
  21. Nagata T, Fujino Y, Saito K, Uehara M, Oyama I, Izumi H, Kubo T. Diagnostic accuracy of the work functioning impairment scale (WFun): a method to detect workers who have health problems affecting their work and to evaluate fitness for work. J Occup Environ Med 2017 Jun;59(6):557-62.
  22. Burton WN, Pransky G, Conti DJ, Chen C-Y, Edington DW. The association of medical conditions and presenteeism. J Occup Environ Med 2004 Jun;46(6 Suppl. l):S38-45.
  23. CDC. Ending isolation and precautions for people with COVID-19: interim guidance [Internet]. Centers for Disease Control and Prevention. 2023 [cited 2023 Jun 6]. Available from: https://www.cdc.gov/coronavirus/2019-ncov/hcp/duration-isolation.html.
  24. van Kampen JJA, van de Vijver DAMC, Fraaij PLA, Haagmans BL, Lamers MM, Okba N, van den Akker JP, Endeman H, Gommers DA, Cornelissen JJ, Hoek RAS, van der Eerden MM, Hesselink DA, Metselaar HJ, Verbon A, de Steenwinkel JEM, Aron GI, van Gorp ECM, van Boheemen S, Voermans JC, Boucher CAB, Molenkamp R, Koopmans MPG, Geurtsvankessel C, van der Eijk AA. Duration and key determinants of infectious virus shedding in hospitalized patients with coronavirus disease-2019 (COVID-19). Nat Commun 2021 Jan 11;12(1):267.
  25. Mazza MG, Palladini M, De Lorenzo R, Magnaghi C, Poletti S, Furlan R, Ciceri F, COVID-19 BioB Outpatient Clinic Study group, Rovere-Querini P, Benedetti F. Persistent psychopathology and neurocognitive impairment in COVID-19 survivors: effect of inflammatory biomarkers at three-month follow-up. Brain Behav Immun 2021 May;94:138-47.
  26. Loeppke R, Taitel M, Haufle V, Parry T, Kessler RC, Jinnett K. Health and productivity as a business strategy: a multiemployer study. J Occup Environ Med 2009 Apr;51(4):411-28.
  27. Nordvig AS, Rajan M, Lau JD, Kingery JR, Mahmud M, Chiang GC, De Leon MJ, Goyal P. Brain fog in long COVID limits function and health status, independently of hospital severity and preexisting conditions. Front Neurol 2023 May 11;14:1150096.
  28. Solomon IH, Normandin E, Bhattacharyya S, Mukerji SS, Keller K, Ali AS, Adams G, Hornick JL, Padera RF, Jr, Sabeti P. Neuropathological features of covid-19. N Engl J Med 2020 Sep 3;383(10):989-92.
  29. Boldrini M, Canoll PD, Klein RS. How COVID-19 affects the brain. JAMA Psychiatry 2021 Jun 1;78(6):682-3.
  30. Ceban F, Ling S, Lui LMW, Lee Y, Gill H, Teopiz KM, Rodrigues NB, Subramaniapillai M, Di Vincenzo JD, Cao B, Lin K, Mansur RB, Ho RC, Rosenblat JD, Miskowiak KW, Vinberg M, Maletic V, McIntyre RS. Fatigue and cognitive impairment in Post-COVID-19 Syndrome: a systematic review and meta-analysis. Brain Behav Immun 2022 Mar;101:93-135.
  31. Morin L, Savale L, Pham T, Colle R, Figueiredo S, Harrois A, Gasnier M, Lecoq AL, Meyrignac O, Noel N, Baudry E, Bellin MF, Beurnier A, Choucha W, Corruble E, Dortet L, Hardy-Leger I, Radiguer F, Sportouch S, Verny C, Wyplosz B, Zaidan M, Becquemont L, Montani D, Monnet X. Writing Committee for the COMEBAC Study Group. Four-month clinical status of a cohort of patients after hospitalization for COVID-19. JAMA 2021 Apr 20;325(15):1525-34.
  32. Kamal M, Abo Omirah M, Hussein A, Saeed H. Assessment and characterisation of post-COVID-19 manifestations. Int J Clin Pract 2021 Mar;75(3):e13746.
  33. Tsampasian V, Elghazaly H, Chattopadhyay R, Debski M, TKP Naing, Garg P, Clark A, Ntatsaki E, Vassiliou VS. Risk factors associated with post-COVID-19 condition: a systematic review and meta-analysis. JAMA Intern Med 2023 Jun 1;183(6):566-80.
  34. Bourmistrova NW, Solomon T, Braude P, Strawbridge R, Carter B. Long-term effects of COVID-19 on mental health: a systematic review. J Affect Disord 2022 Feb 15;299:118-25.