Clinical and Experimental Reproductive Medicine

  • 제50권4호
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  • Pages.223-229
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  • 2023
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  • 2233-8233(pISSN)
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  • 2233-8241(eISSN)
대한생식의학회 (The Korean Society for Reproductive Medicine)
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Dienogest in endometriosis treatment: A narrative literature review

  • Joowon Lee (Department of Obstetrics and Gynecology, Korea University College of Medicine) ;
  • Hyeon Ji Park (Department of Obstetrics and Gynecology, Korea University College of Medicine) ;
  • Kyong Wook Yi (Department of Obstetrics and Gynecology, Korea University College of Medicine)
  • 투고 : 2023.05.12
  • 심사 : 2023.08.09
  • 발행 : 2023.12.31
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초록

Endometriosis is characterized by the implantation of endometrial cells outside the uterus. This hormone-dependent disease is highly prevalent among women of reproductive age. Clinical symptoms of endometriosis include dysmenorrhea, pelvic pain, and infertility, which can negatively impact the overall quality of life of those affected. The medical treatment of endometriosis serves as an important therapeutic option, aimed at alleviating pain associated with the condition and suppressing the growth of endometriotic lesions. As such, it is employed as an adjuvant therapy following surgery or an empirical treatment after the clinical diagnosis of endometriosis. Dienogest, a fourth-generation progestin, has received approval for the treatment of endometriosis in many countries. A growing body of evidence has demonstrated its efficacy in managing endometriosis-associated pain, preventing symptoms, and reducing lesion recurrence. In this review, we examine the clinical efficacy, safety, and tolerability of dienogest in treating endometriosis. We also provide updated findings, drawing from clinical studies that focus on the long-term use of this medication in patients with endometriosis.

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참고문헌

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