Journal of Periodontal and Implant Science

  • 제53권6호
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  • Pages.417-428
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  • 2023
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  • 2093-2278(pISSN)
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  • 2093-2286(eISSN)
대한치주과학회 (Korean Academy of Periodontology)
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Effect of polydeoxyribonucleotide with xenogeneic collagen matrix on gingival phenotype modification: a pilot preclinical study

  • Hyun-Chang Lim (Department of Periodontology, College of Dentistry, Kyung Hee University, Periodontal-Implant Clinical Research Institute, Kyung Hee University Medical Center) ;
  • Chang-Hoon Kim (Department of Dentistry, Graduate School, Kyung Hee University) ;
  • Han-Kyu Lee (Department of Dentistry, Graduate School, Kyung Hee University) ;
  • Gyewon Jeon (Department of Dentistry, Graduate School, Kyung Hee University) ;
  • Yeek Herr (Department of Periodontology, College of Dentistry, Kyung Hee University, Periodontal-Implant Clinical Research Institute, Kyung Hee University Medical Center) ;
  • Jong-Hyuk Chung (Department of Periodontology, College of Dentistry, Kyung Hee University, Periodontal-Implant Clinical Research Institute, Kyung Hee University Medical Center)
  • 투고 : 2023.04.07
  • 심사 : 2023.05.23
  • 발행 : 2023.12.31
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초록

Purpose: To investigate the effect of xenogeneic collagen matrix (XCM) with polydeoxyribonucleotide (PDRN) for gingival phenotype modification compared to autogenous connective tissue graft. Methods: Five mongrel dogs were used in this study. Box-type gingival defects were surgically created bilaterally on the maxillary canines 8 weeks before gingival augmentation. A coronally positioned flap was performed with either a subepithelial connective tissue graft (SCTG) or XCM with PDRN (2.0 mg/mL). The animals were sacrificed after 12 weeks. Intraoral scanning was performed for soft tissue analysis, and histologic and histomorphometric analyses were performed. Results: One animal exhibited wound dehiscence, leaving 4 for analysis. Superimposition of STL files revealed no significant difference in the amount of gingival thickness increase (ranging from 0.69±0.25 mm to 0.80±0.31 mm in group SCTG and from 0.48±0.25 mm to 0.85±0.44 mm in group PDRN; P>0.05). Histomorphometric analysis showed no significant differences between the groups in supracrestal gingival tissue height, keratinized tissue height, tissue thickness, and rete peg density (P>0.05). Conclusions: XCM soaked with PDRN yielded comparable gingival augmentation to SCTG.

키워드

과제정보

This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (No.2020R1C1C1008201). The PDRN was kindly provided by Genoss.

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