Molecules and Cells

Korean Society for Molecular and Cellular Biology (한국분자세포생물학회)
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Macrophages Keep Your Gut Moving

  • Chan Hee Lee (Program of Material Science for Medicine and Pharmaceutics, Hallym University) ;
  • Min-Seon Kim (Division of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine)
  • Received : 2023.08.01
  • Accepted : 2023.08.17
  • Published : 2023.11.30
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Abstract

Schematic diagram of the interaction between the intestinal muscularis externa (MMΦ) macrophages and the enteric nervous system (ENS) neurons during different developmental periods. At the early postnatal stage, MMΦs play a critical role in ENS maturation and refinement through synaptic pruning and enteric neuron phagocytosis. In addition, during the adult stage, a specific MMΦ subset named neuron-associated (NA)-MMΦ, supports enteric neuronal survival and functions. Conversely, enteric neurons promote the phenotypic MMΦ changes by secreting transforming growth factor-β (TGFβ), transitioning them from a phagocytic phenotype in the early postnatal period to a neuroprotective and immune-surveillant phenotype in the young adult period. Disruptions in these interactions could lead to alterations in the enteric neuron numbers, ultimately resulting in reduced gut motility.

Keywords

Acknowledgement

This study was supported by grants from the National Research Foundation of Korea (NRF), funded by the Ministry of Science and ICT of Korea (2020R1A2C3004843, 2022M3E5E8017213, 2022R1C1C1004187).

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