Journal of Pharmacopuncture (대한약침학회지)

KOREAN PHARMACOPUNCTURE INSTITUTE (대한약침학회)
권호 표지
DOI QR코드

DOI QR Code

A Brief Review on Murraya paniculata (Orange Jasmine): pharmacognosy, phytochemistry and ethanomedicinal uses

  • Deepa, Joshi (Department of Pharmacology, Anand College of Pharmacy) ;
  • Kashmira J., Gohil (Department of Pharmacology, Anand College of Pharmacy)
  • Received : 2022.11.02
  • Accepted : 2023.02.08
  • Published : 2023.03.31
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives: Murraya paniculata (family-Rutaceae), popularly known as orange jasmine, is the most important evergreen plant. The Rutaceae family is economically significant due to its diverse edible fruits and essential oils. Methods: Murraya paniculata extracts (MPE) of leaf have been shown to include phenolic compounds, highly oxygenated flavonoids, flavanones, sesquiterpenoids, polymethoxy glycosides, and coumarins. Cyclocitral, methyl salicylate, trans-nerolidol, cubenol, isogermacrene, -cadinol, and cubeb-11-ene are all abundant in MPE. The usages of various parts of this plant, such as bark, leaves and flower, as a remedy for a variety of ailments as widely recorded in the traditional literature. The plant has anti-diabetic, anti-obesity, antibacterial, anti-implantation, anti-oxidative, cytotoxic, anti-diarrheal, antidepressant and anti-anxiety properties and many others. Results: The goal of the review is to reignite interest in this potential plant, encouraging researchers to continue their research in order to uncover novel therapeutic compounds for the treatment and management of a range of infections. The current review provided a comprehensive overview of this traditional unique plant. Conclusion: The review paves a way for exploring its active chemical elements with substantial pharmacological values further for potential benefits of mankind.

Keywords

References

  1. Gohil KJ, Patel JA. A review on Bacopa monniera: current research and future prospects. Int J Green Pharm. 2010;4(1):1-9.  https://doi.org/10.4103/0973-8258.62156
  2. Gohil KJ, Patel JA, Gajjar AK. Pharmacological review on Centella asiatica: a potential herbal cure-all. Indian J Pharm Sci. 2010;72(5):546-56.  https://doi.org/10.4103/0250-474X.78519
  3. Gautam MK, Goel RK. Exploration of preliminary phytochemical studies of leaves of Murraya paniculata (L.). Int J Pharm Life Sci. 2012;3(8):1871-4. 
  4. Saeed S, Shah S, Mehmood R, Malik A. Paniculacin, a new coumarin derivative from Murraya paniculata. J Asian Nat Prod Res. 2011;13(8):724-7.  https://doi.org/10.1080/10286020.2011.586343
  5. Tomaseto AF, Marques RN, Fereres A, Zanardi OZ, Volpe HXL, Alquezar B, et al. Orange jasmine as a trap crop to control Diaphorina citri. Sci Rep. 2019;9(1):2070. 
  6. Kong YC, Ng GKH, Wat CKH, But PPH. Pharmacognostic differentiation between Murraya paniculata (L.) Jack and Murraya koenigii (L.) Spreng. Int J Crude Drug Res. 1986;24(3):167-70.  https://doi.org/10.3109/13880208609060894
  7. Faisal M, Sarker MMH, Rahman A, Hossain AI, Rahman S, Bashar ABMA, et al. Murraya paniculata (L.) Jack: a potential plant for treatment of toothache. J Dent Oral Disord Ther. 2014;2(3):1-3.  https://doi.org/10.15226/jdodt.2014.00123
  8. Gilman EF. Fact Sheet FPS-416: Murraya paniculata. Gainesville: University of Florida; 1999. 
  9. Wardani E, Harahap Y, Mun'im A, Bahtiar A. Influence of extraction on the yield, phytochemical and LCMS profile from standardized kemuning leaf (Murraya paniculata (L.) Jack). Pharmacogn J. 2019;11(6 Suppl):1455-62.  https://doi.org/10.5530/pj.2019.11.225
  10. Wilson A, Kuchlmayr B, Moon C, McCusker A, Zhang X. Flora of Australia volume 26: Meliaceae, Rutaceae, Zygophyllaceae. Melbourne: ABRS, Canberra/CSIRO Publishing; 2013. pp. 502-3. 
  11. Liu H, Zhao Y, Zhou J, Ma Q, Wang X, Hua Z. Complete chloroplast genome sequence of Murraya paniculata (Rutaceae): a widely used folk medicinal herb. Mitochondrial DNA B Resour. 2020;5(3):3696-7.  https://doi.org/10.1080/23802359.2020.1829518
  12. Ng MK, Abdulhadi-Noaman Y, Cheah YK, Yeap SK, Alitheen NB. Bioactivity studies and chemical constituents of Murraya paniculata (Linn) Jack. Int Food Res J. 2012;19(4):1307-12. 
  13. Sayar K, Paydar M, Pingguan-Murphy B. Pharmacological properties and chemical constituents of Murraya paniculata (L.) Jack. Med Aromat Plants. 2014;3(4):1000173.  https://doi.org/10.4172/2167-0412.1000167
  14. Monir TSB, Afroz S, Jahan I, Hossain T. Phytochemical study and antioxidant properties of aqueous extracts of Murraya paniculata Leaf. J Appl Life Sci Int. 2020;23(4):1-8.  https://doi.org/10.9734/jalsi/2020/v23i430153
  15. Wu TS. Coumarins from the leaves of Murraya paniculata. Phytochemistry. 1988;27(7):2357-8.  https://doi.org/10.1016/0031-9422(88)80163-8
  16. Kinoshita T, Firman K. Highly oxygenated flavonoids from Murraya paniculata. Phytochemistry. 1996;42(4):1207-10.  https://doi.org/10.1016/0031-9422(96)00058-1
  17. Sangkaew A, Samritsakulchai N, Sanachai K, Rungrotmongkol T, Chavasiri W, Yompakdee C. Two flavonoid-based compounds from Murraya paniculata as novel human carbonic anhydrase isozyme II inhibitors detected by a resazurin yeast-based assay. J Microbiol Biotechnol. 2020;30(4):552-60.  https://doi.org/10.4014/jmb.1910.10037
  18. Zhang Y, Li J, Shi S, Zan K, Tu P. Glycosides of flavone methyl ethers from Murraya paniculata. Biochem Syst Ecol. 2012;43:10-3.  https://doi.org/10.1016/j.bse.2011.10.003
  19. Zhang JY, Li N, Che YY, Zhang Y, Liang SX, Zhao MB, et al. Characterization of seventy polymethoxylated flavonoids (PMFs) in the leaves of Murraya paniculata by on-line high-performance liquid chromatography coupled to photodiode array detection and electrospray tandem mass spectrometry. J Pharm Biomed Anal. 2011;56(5):950-61.  https://doi.org/10.1016/j.jpba.2011.08.019
  20. Liang H, Zhao M, Tu P, Jiang Y. Polymethoxylated flavonoids from Murraya paniculata (L.) Jack. Biochem Syst Ecol. 2020;93:104162. 
  21. Barros FAP, Rodrigues-Filho E. Four spiroquinazoline alkaloids from Eupenicillium sp. isolated as an endophytic fungus from leaves of Murraya paniculata (Rutaceae). Biochem Syst Ecol. 2005;33(3):257-68.  https://doi.org/10.1016/j.bse.2004.09.002
  22. Shaikh A, Choudhary MI. Bioassay studies of 2'-O-ethylmurrangatin isolated from a medicinal plant, Murraya paniculata. Turk J Biol. 2011;35(6):751-5.  https://doi.org/10.3906/biy-1005-161
  23. Wang XT, Zeng KW, Zhao MB, Tu PF, Li J, Jiang Y. Three new indole alkaloid derivatives from the roots of Murraya paniculata. J Asian Nat Prod Res. 2018;20(3):201-8.  https://doi.org/10.1080/10286020.2017.1327950
  24. Wang X, Liang H, Zeng K, Zhao M, Tu P, Li J, et al. Panitins A-G: coumarin derivatives from Murraya paniculata from Guangxi Province, China show variable NO inhibitory activity. Phytochemistry. 2019;162:224-31.  https://doi.org/10.1016/j.phytochem.2019.03.012
  25. Ito C, Furukawa H, Ishii H, Ishikawa T, Haginiwa J. The chemical composition of Murraya paniculata. The structure of five new coumarins and one new alkaloid and the stereochemistry of murrangatin and related coumarins. J Chem Soc Perkin Trans 1. 1990;7:2047-55.  https://doi.org/10.1039/p19900002047
  26. Kong YC, Ng KH, Wat KH, Wong A, Saxena IF, Cheng KF, et al. Yuehchukene, a novel anti-implantation indole alkaloid from Murraya paniculata. Planta Med. 1985;51(4):304-7.  https://doi.org/10.1055/s-2007-969497
  27. Wu TS, Liou MJ, Kuoh CS. Coumarins of the flowers of Murraya paniculata. Phytochemistry. 1989;28(1):293-4.  https://doi.org/10.1016/0031-9422(89)85066-6
  28. Wu TS, Chan YY, Leu YL, Huang SC. A flavonoid and indole alkaloid from flowers of Murraya paniculata. Phytochemistry. 1994;37(1):287-8.  https://doi.org/10.1016/0031-9422(94)85045-3
  29. Saied S, Nizami SS, Anis I. Two new coumarins from Murraya paniculata. J Asian Nat Prod Res. 2008;10(5-6):515-9.  https://doi.org/10.1080/10286020801967292
  30. Shah S, Saied S, Mahmood A, Malik A. Phytochemical screening of volatile constituents from aerial parts of Murraya paniculata. Pak J Bot. 2014;46(6):2051-6. 
  31. Mondal SK, Ray B, Ghosal PK, Teleman A, Vuorinen T. Structural features of a water soluble gum polysaccharide from Murraya paniculata fruits. Int J Biol Macromol. 2001;29(3):169-74.  https://doi.org/10.1016/S0141-8130(01)00169-6
  32. Olawore NO, Ogunwande IA, Ekundayo O, Adeleke KA. Chemical composition of the leaf and fruit essential oils of Murraya paniculata (L.) Jack. (Syn. Murraya exotica Linn.). Flavour Fragr J. 2005;20(1):54-5.  https://doi.org/10.1002/ffj.1365
  33. Chowdhury JU, Bhuiyan MNI, Yusuf M. Chemical composition of the leaf essential oils of Murraya koenigii (L.) Spreng and Murraya paniculata (L.) Jack. Bangladesh J Pharm. 2008;3(2):59-63.  https://doi.org/10.3329/bjp.v3i2.841
  34. Podder MK, Das BN, Saha A, Ahmed M. Analgesic activity of bark of Murraya paniculata. Int J Med Med Sci. 2011;3(4):105-8. 
  35. Narkhede MB, Ajmire PV, Wagh AE. Evaluation of antinociceptive and anti-inflammatory activity of ethanol extract of Murraya paniculata leaves in experimental rodents. Int J Pharm Pharm Sci. 2012;4(1):247-50. 
  36. Sharker SM, Shahid IJ, Hasanuzzaman M. Antinociceptive and bioactivity of leaves of Murraya paniculata (L.) Jack, Rutaceae. Rev Bras Farmacogn. 2009;19(3):746-8.  https://doi.org/10.1590/S0102-695X2009000500016
  37. Saqib F, Ahmed MG, Janbaz KH, Dewanjee S, Jaafar HZ, ZiaUl-Haq M. Validation of ethnopharmacological uses of Murraya paniculata in disorders of diarrhea, asthma and hypertension. BMC Complement Altern Med. 2015;15:319. 
  38. Rahman MA, Hasanuzzaman M, Uddin N, Shahid I. Antidiarrhoeal and anti-inflammatory activities of Murraya paniculata (L.) Jack. Pharmacologyonline. 2010;3:768-76. 
  39. Wu J, Liu K, Shi X. The anti-inflammatory activity of several flavonoids isolated from Murraya paniculata on murine macrophage cell line and gastric epithelial cell (GES-1). Pharm Biol. 2016;54(5):868-81.  https://doi.org/10.3109/13880209.2015.1089294
  40. Zou J, Sui D, Fu W, Li Y, Yu P, Yu X, et al. Total flavonoids extracted from the leaves of Murraya paniculata (L.) Jack alleviate oxidative stress, inflammation and apoptosis in a rat model of diabetic cardiomyopathy. J Funct Foods. 2021;76:104319. 
  41. Zhu CH, Lei ZL, Luo YP. Studies on antioxidative activities of methanol extract from Murraya paniculata. Food Sci Hum Wellness. 2015;4(3):108-14.  https://doi.org/10.1016/j.fshw.2015.07.001
  42. Sundaram M, Sivakumar, Karthikeyan, Bhuvaneshwari, Aishwarya, Thirumalai, et al. Studies on in vitro antibacterial, antifungal property and antioxidant potency of Murraya paniculata. Pak J Nutr. 2011;10(10):925-9.  https://doi.org/10.3923/pjn.2011.925.929
  43. Gautam MK, Gangwar M, Nath G, Rao CV, Goel RK. In-vitro antibacterial activity on human pathogens and total phenolic, flavonoid contents of Murraya paniculata Linn. leaves. Asian Pac J Trop Biomed. 2012;2(3 Suppl):S1660-3.  https://doi.org/10.1016/S2221-1691(12)60472-9
  44. Sonter S, Mishra S, Dwivedi MK, Singh PK. Chemical profiling, in vitro antioxidant, membrane stabilizing and antimicrobial properties of wild growing Murraya paniculata from Amarkantak (M.P.). Sci Rep. 2021;11(1):9691. 
  45. Punasiya R, Dindorkar G, Pillai S. Antibacterial and antifungal activity of flower extract of Murraya paniculata L. Asian J Res Pharm Sci. 2020;10(1):17-20.  https://doi.org/10.5958/2231-5659.2020.00004.1
  46. Dosoky NS, Satyal P, Gautam TP, Setzer WN. Composition and biological activities of Murraya paniculata (L.) Jack essential oil from Nepal. Medicines (Basel). 2016;3(1):7. 
  47. Wiyogo IO, Endraswari PD, Setiawati Y. Antibacterial activity of ethanol extract of Kemuning (Murraya Paniculata) against Klebsiella pneumoniae ESBL by in vitro test. Indones J Trop Infect Dis. 2021;9(2):101-6.  https://doi.org/10.20473/ijtid.v9i2.9328
  48. Baker DHA, Ibrahim EA, Kandeil A, Baz FKE. Sterols bioactivity of Ruta graveolens L. and Murraya paniculata L. Int J Pharm Pharm Sci. 2017;9(2):103-8.  https://doi.org/10.22159/ijpps.2017v9i2.15790
  49. Rodanant P, Khetkam P, Suksamrarn A, Kuvatanasuchati J. Coumarins and flavonoid from Murraya paniculata (L.) Jack: antibacterial and anti-inflammation activity. Pak J Pharm Sci. 2015;28(6):1947-51. 
  50. Rumzhum NN, Rahman MM, Hossain MF. Free radical scavenging activity and cytotoxic potential of crude extractives of Murraya paniculata (L.) bark. Res J Pharmacogn Phytochem. 2012;4(1):18-22. 
  51. Shi Q, Jiang Z, Yang J, Cheng Y, Pang Y, Zheng N, et al. A flavonoid glycoside compound from Murraya paniculata (L.) interrupts metastatic characteristics of A549 cells by regulating STAT3/NF-κB/COX-2 and EGFR signaling pathways. AAPS J. 2017;19(6):1779-90.  https://doi.org/10.1208/s12248-017-0134-0
  52. Nesa M, Hosen ME, Khan MAI, Kabir MH, Zaman R. In-vitro antifungal activity of Azadirachta indica, Ocimum tenuiflorum & Murraya paniculata leaf extract against three phytopathogenic fungi. Am J Pure Appl Sci. 2021;3(5):113-8.  https://doi.org/10.34104/ajpab.021.01130118
  53. Boonkusol D, Detraksa J, Duangsrikaew K, Tongbai W. In vivo efficacy of Murraya paniculata leaf in controlling natural helminthiasis in goat. Am J Anim Vet Sci. 2019;14(2):95-100.  https://doi.org/10.3844/ajavsp.2019.95.100
  54. Tresia GE, Evvyernie D, Tiuria R. Phytochemical screening and in vitro ovicidal, larvacidal, and nematicidal effects of Murraya paniculata (L.) Jack extract on gastrointestinal parasites of goats. Media Peternak. 2016;39(3):173-9.  https://doi.org/10.5398/medpet.2016.39.3.173
  55. Sharma P, Batra S, Kumar A, Sharma A. In vivo antianxiety and antidepressant activity of Murraya paniculata leaf extracts. J Integr Med. 2017;15(4):320-5.  https://doi.org/10.1016/s2095-4964(17)60352-2
  56. Lu M, Du Z, Yuan S, Ma Q, Han Z, Tu P, et al. Comparison of the preventive effects of Murraya exotica and Murraya paniculata on alcohol-induced gastric lesions by pharmacodynamics and metabolomics. J Ethnopharmacol. 2021;281:114567. 
  57. Zou J, Yu X, Qu S, Li X, Jin Y, Sui D. Protective effect of total flavonoids extracted from the leaves of Murraya paniculata (L.) Jack on diabetic nephropathy in rats. Food Chem Toxicol. 2014;64:231-7.  https://doi.org/10.1016/j.fct.2013.11.043
  58. Iswantini D, Silitonga RF, Martatilofa E, Darusman LK. Zingiber cassumunar, Guazuma ulmifolia, and Murraya paniculata extracts as antiobesity: in vitro inhibitory effect on pancreatic lipase activity. HAYATI J Biosci. 2011;18(1):6-10.  https://doi.org/10.4308/hjb.18.1.6
  59. Gautam MK, Gupta A, Vijaykumar M, Rao CV, Goel RK. Studies on the hypoglycemic effects of Murraya paniculata Linn. extract on alloxan-induced oxidative stress in diabetic and nondiabetic models. Asian Pac J Trop Dis. 2012;2 Suppl 1:S186-91.  https://doi.org/10.1016/S2222-1808(12)60149-2
  60. Gautam M, Gupta A, Rao CV, Goel R. Antihyperglycemic and antioxidant potential of murraya paniculata linn. Leaves: a preclinical study. J Pharm Res. 2012;5(3):1334-7. 
  61. Menezes CDA, de Oliveira Garcia FA, de Barros Viana GS, Pinheiro PG, Felipe CFB, de Albuquerque TR, et al. Murraya paniculata (L.) (Orange Jasmine): potential nutraceuticals with ameliorative effect in alloxan-induced diabetic rats. Phytother Res. 2017;31(11):1747-56.  https://doi.org/10.1002/ptr.5903
  62. Gautam MK, Singh A, Rao CV, Goel RK. Toxicological evaluation of Murraya paniculata (L.) leaves extract on rodents. Am J Pharmacol Toxicol. 2012;7(2):62-7.  https://doi.org/10.3844/ajptsp.2012.62.67
  63. Menezes IR, Santana TI, Varela VJ, Saraiva RA, Matias EF, Boligon AA, et al. Chemical composition and evaluation of acute toxicological, antimicrobial and modulatory resistance of the extract of Murraya paniculata. Pharm Biol. 2015;53(2):185-91. https://doi.org/10.3109/13880209.2014.913068