과제정보
This work was supported by funding from the National Natural Science Foundation of China (No. 81773934).
참고문헌
- Rivankar S. An overview of doxorubicin formulations in cancer therapy. J Cancer Res Ther 2014;10:853-8. https://doi.org/10.4103/0973-1482.139267
- Zhao H, Yao Y, Wang Z, Lin F, Sun Y, Chen P. Therapeutic effect of pirarubicinbased chemotherapy for osteosarcoma patients with lung metastasis. J Chemother 2010;22:119-24. https://doi.org/10.1179/joc.2010.22.2.119
- Valcovici M, Andrica F, Serban C, Dragan S. Cardiotoxicity of anthracycline therapy: current perspectives. Arch Med Sci 2016;12:428-35. https://doi.org/10.5114/aoms.2016.59270
- Wang YD, Zhang Y, Sun B, Leng XW, Li YJ, Ren LQ. Cardioprotective effects of rutin in rats exposed to pirarubicin toxicity. J Asian Nat Prod Res 2018;20:361-73. https://doi.org/10.1080/10286020.2017.1394292
- Kim JK, Cui CH, Yoon MH, Kim SC, Im WT. Bioconversion of major ginsenosides Rg1 to minor ginsenoside F1 using novel recombinant ginsenoside hydrolyzing glycosidase cloned from Sanguibacter keddieii and enzyme characterization. J Biotechnol 2012;161:294-301. https://doi.org/10.1016/j.jbiotec.2012.06.021
- Kim JH, Baek EJ, Lee EJ, Yeom MH, Park JS, Lee KW, Kang NJ. Ginsenoside F1 attenuates hyperpigmentation in B16F10 melanoma cells by inducing dendrite retraction and activating Rho signalling. Exp Dermatol 2015;24:150-2. https://doi.org/10.1111/exd.12586
- Wang Y, Choi KD, Yu H, Jin F, Im WT. Production of ginsenoside F1 using commercial enzyme Cellulase KN. J Ginseng Res 2016;40:121-6. https://doi.org/10.1016/j.jgr.2015.06.003
- Wang F, Pu C, Zhou P, Wang P, Liang D, Wang Q, Hu Y, Li B, Hao X. Cinnamaldehyde prevents endothelial dysfunction induced by high glucose by activating Nrf2. Cell Physiol Biochem 2015;36:315-24. https://doi.org/10.1159/000374074
- Luo C, Urgard E, Vooder T, Metspalu A. The role of COX-2 and Nrf2/ARE in antiinflammation and antioxidative stress: aging and anti-aging. Med Hypotheses 2011;77:174-8. https://doi.org/10.1016/j.mehy.2011.04.002
- Tran PL, Kim O, Tran HNK, Tran MH, Min BS, Hwangbo C, Lee JH. Protective effects of extract of Cleistocalyx operculatus flower buds and its isolated major constituent against LPS-induced endotoxic shock by activating the Nrf2/HO-1 pathway. Food Chem Toxicol 2019;129:125-37. https://doi.org/10.1016/j.fct.2019.04.035
- Chen QM. Nrf2 for cardiac protection: pharmacological options against oxidative stress. Trends Pharmacol Sci 2021;42:729-44. https://doi.org/10.1016/j.tips.2021.06.005
- Zhang Y, Ma XY, Zhang T, Qin M, Sun B, Li Q, Hu DW, Ren LQ. Protective effects of apocynum venetum against pirarubicin-induced cardiotoxicity. Am J Chin Med 2019;47:1075-97. https://doi.org/10.1142/s0192415x19500551
- Das S, Steenbergen C. Mitochondrial adenine nucleotide transport and cardioprotection. J Mol Cell Cardiol 2012;52:448-53. https://doi.org/10.1016/j.yjmcc.2011.09.007
- Alvarez S, Valdez LB, Zaobornyj T, Boveris A. Oxygen dependence of mitochondrial nitric oxide synthase activity. Biochem Biophys Res Commun 2003;305:771-5. https://doi.org/10.1016/S0006-291X(03)00818-0
- Adam-Vizi V, Chinopoulos C. Bioenergetics and the formation of mitochondrial reactive oxygen species. Trends Pharmacol Sci 2006;27:639-45. https://doi.org/10.1016/j.tips.2006.10.005
- Zhang Y, Ma C, Liu C, Wei F. Luteolin attenuates doxorubicin-induced cardiotoxicity by modulating the PHLPP1/AKT/Bcl-2 signalling pathway. PeerJ 2020;8:-8845.
- Wang CM, Li HF, Wang XK, Li WG, Su Q, Xiao X, Hao TF, Chen W, Zhang YW, Zhang HY, et al. Ailanthus Altissima-derived Ailanthone enhances Gastric Cancer Cell Apoptosis by Inducing the Repression of Base Excision Repair by Downregulating p23 Expression. Int J Biol Sci. 2021;17:2811-25. https://doi.org/10.7150/ijbs.60674
- Zhu W, Ding J, Sun L, Wu J, Xu X, Wang W, Li H, Shen H, Li X, Yu Z, et al. Heterogeneous nuclear ribonucleoprotein A1 exerts protective role in intracerebral hemorrhage-induced secondary brain injury in rats. Brain Res Bull 2020;165:169-77. https://doi.org/10.1016/j.brainresbull.2020.09.023
- Zhang J, Cui X, Yan Y, Li M, Yang Y, Wang J, Zhang J. Research progress of cardioprotective agents for prevention of anthracycline cardiotoxicity. Am J Transl Res 2016;8:2862-75.
- Shi H, Tang H, Ai W, Zeng Q, Yang H, Zhu F, Wei Y, Feng R, Wen L, Pu P, et al. Schisandrin B antagonizes cardiotoxicity induced by pirarubicin by inhibiting mitochondrial permeability transition pore (mPTP) opening and decreasing cardiomyocyte apoptosis. Front Pharmacol 2021;12:733805. https://doi.org/10.3389/fphar.2021.733805
- Zhang J, Liu M, Huang M, Chen M, Zhang D, Luo L, Ye G, Deng L, Peng Y, Wu X, et al. Ginsenoside F1 promotes angiogenesis by activating the IGF-1/IGF1R pathway. Pharmacol Res 2019;144:292-305. https://doi.org/10.1016/j.phrs.2019.04.021
- Qin M, Luo Y, Lu S, Sun J, Yang K, Sun J, Yang K, Sun G, Sun X. Ginsenoside F1 ameliorates endothelial cell inflammatory injury and prevents atherosclerosis in mice through A20-mediated suppression of NF-kB signaling. Front Pharmacol 2017;8:953. https://doi.org/10.3389/fphar.2017.00953
- Songbo M, Lang H, Xinyong C, Bin X, Ping Z, Liang S. Oxidative stress injury in doxorubicin-induced cardiotoxicity. Toxicol Lett 2019;307:41-8. https://doi.org/10.1016/j.toxlet.2019.02.013
- Sun XP, Wan LL, Yang QJ, Huo Y, Han YL, Guo C. Scutellarin protects against doxorubicin-induced acute cardiotoxicity and regulates its accumulation in the heart. Arch Pharm Res 2017;40:875-83. https://doi.org/10.1007/s12272-017-0907-0
- Wang Y, Liang X, Chen Y, Zhao X. Screening SIRT1 activators from medicinal plants as bioactive compounds against oxidative damage in mitochondrial function. Oxid Med Cell Longev 2016;2016:4206392. https://doi.org/10.1155/2016/4206392
- Jing L, Yang M, Li Y, Yu Y, Liang B, Cao L, Zhou X, Peng S, Sun Z. Metallothionein prevents doxorubicin cardiac toxicity by indirectly regulating the uncoupling proteins 2. Food Chem Toxicol 2017;110:204-13. https://doi.org/10.1016/j.fct.2017.10.035
- Zhao L, Qi Y, Xu L, Tao X, Han X, Yin L, Peng J. MicroRNA-140-5p aggravates doxorubicin-induced cardiotoxicity by promoting myocardial oxidative stress via targeting Nrf2 and Sirt2. Redox Biol 2018;15:284-96. https://doi.org/10.1016/j.redox.2017.12.013
- Peng H, You L, Yang C, Wang K, Liu M, Yin D, Xu Y, Dong X, Yin X, Ni J. Ginsenoside Rb1 attenuates triptolide-induced cytotoxicity in HL-7702 cells via the activation of keap1/Nrf2/ARE pathway. Front Pharmacol 2021;12:723784. https://doi.org/10.3389/fphar.2021.723784
- Lindsay J, Esposti MD, Gilmore AP. Bcl-2 proteins and mitochondria-specificity in membrane targeting for death. Biochim Biophys Acta 2011;1813:532-9. https://doi.org/10.1016/j.bbamcr.2010.10.017
- Song XF, Tian H, Zhang P, Zhang ZX. Expression of cyt-c-mediated mitochondrial apoptosis-related proteins in rat renal proximal tubules during development. Nephron 2017;135:77-86. https://doi.org/10.1159/000450585
- Manning BD, Toker A. AKT/PKB signaling: Navigating the Network. Cell 2017;169:381-405. https://doi.org/10.1016/j.cell.2017.04.001
- Wang F, Wang L, Jiao Y, Wang Z. Qishen Huanwu capsule reduces pirarubicininduced cardiotoxicity in rats by activating the PI3K/Akt/mTOR pathway. Ann Palliat Med 2020;9:3453-61. https://doi.org/10.21037/apm-20-1746
- Lee EH, Cho SY, Kim SJ, Shin ES, Chang HK, Kim DH, Yeom MH, Woe KS, Lee J, Sim YC, et al. Ginsenoside F1 protects human HaCaT keratinocytes from ultraviolet-B-induced apoptosis by maintaining constant levels of Bcl-2. J Invest Dermatol 2003;121:607-13. https://doi.org/10.1046/j.1523-1747.2003.12425.x