DOI QR코드

DOI QR Code

A Literature Review of Treatments of Stomatitis in Korean Medicine

구내염의 한방 치료에 대한 문헌 고찰

  • Yu-Ra, Im (Dep. of Ophthalmology & Otolaryngology & Dermatology, Haeundae Jaseng Hospital of Korean Medicine) ;
  • Ho-Jun, Jeong (Dep. of Ophthalmology & Otolaryngology & Dermatology, Haeundae Jaseng Hospital of Korean Medicine)
  • 임유라 (해운대자생한방병원 안이비인후피부과) ;
  • 정호준 (해운대자생한방병원 안이비인후피부과)
  • Received : 2023.01.07
  • Accepted : 2023.02.08
  • Published : 2023.02.25

Abstract

Objectives : The purpose of this study is to investigate the treatments of Stomatitis in Korean medicine. Methods : We reviewed domestic journals through databases on RISS, KISS, OASIS, KISTI to search case reports and follow-up studies about 'Stomatitis' and '口瘡' using the terms with 'Korean medicine' or 'Korean medicine treatment'. Also, we used CNKI to find Randomized controlled trials(RCTs) from Chinese journals by using the term '口腔炎'. Results : A total of 16 articles were searched. Those of 7 are case report, 2 are follow-up study, 7 are RCTs. The way to treat stomatitis were through using herb medicine, acupuncture, electro-acupuncture, herbal acupuncture, external preparation, indirect moxibustion and so on. All papers reported that after Korean medicine treatment, symptoms of stomatitis are relieved. Conclusions : According to these journals, Korean medicine is helpful to treat Stomatitis. In the future, more clinical studies are needed to establish the foundation of Korean medicine to treat stomatitis.

Keywords

References

  1. Ko WS, Kwon G, Kim GJ, Kim GS, Kim NG, Kim YB, et al. The Society of Korean Medicine Ophthalmology, Otolaryngology & Dermatology. Textbook of Korean medicine Otolaryngology. Paju:Globooks. 2019:269, 277.
  2. Akintoye SO, Greenberg MS. Recurrent aphthous stomatitis. Dent Clin North Am. 2014;58:281-97. https://doi.org/10.1016/j.cden.2013.12.002
  3. Preeti L, Magesh K, Rajkumar K, Karthik R. Recurrent aphthous stomatitis. J Oral Maxillofac Pathol. 2011;15:252-6. https://doi.org/10.4103/0973-029X.86669
  4. Scully C, Porter S. Oral mucosal disease: Recurrent aphthous stomatitis. Br J Oral Maxillofac Surg. 2008;46:198-206. https://doi.org/10.1016/j.bjoms.2007.07.201
  5. Saxen MA, Ambrosius WT, Rehemtula AF, Russell AL, Eckert GJ. Sustained relief of oral aphthous ulcer pain from topical diclofenac in hyaluronan: a randomized, double-blind clinical trial. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1997;84(4):356-61. https://doi.org/10.1016/S1079-2104(97)90031-7
  6. Sonis S, Edewards L, Lucey C. The biological basis for the attenuation of mucositis: the example of interleukin-11. Leukemia. 1999;13(6):831-4. https://doi.org/10.1038/sj/leu/2401441
  7. Ko WS, Kim GJ, Kim NG, Kim YB, Kim JH, Kim HT, et al. Text of Traditional Korean Dermatology & Surgery. Busan:Sunwoo. 2007:518.
  8. Shulman JD, Beach MM, Rivera-Hidalgo F. The prevalence of oral mucosal lesions in U.S. adults: Data from the Third National Health and Nutrition Examination Survey, 1988-1994. J Am Dent Assoc. 2004;135:1279-86. https://doi.org/10.14219/jada.archive.2004.0403
  9. Paleri V, Staines K, Sloan P, Douglas A, Wilson J. Evaluation of oral ulceration in primary care. BMJ. 2010;340:1234-8. https://doi.org/10.1136/bmj.c2639
  10. Kim IR, Kim HC, Kook YB, Park SJ, Park YG, Park JH, et al. The text book compilation committee of Korean herbology. Herbology. Seoul:Younglimsa. 2016:178,216,222,234,571,585,635.
  11. Lee HC, Lee SW, Bae EJ, Park SU, Yoon SW, Ko CH. A case report recurrent aphthous stomatitis resulted from cessation smoking in strokepatients. Korean J Oriental Int Med. 2003;24(4):967-74.
  12. Chou CY, Huh YS, Won JS, Kim CH. A case of Gu-Chang, treated with External therapy and Herbal medicine. J Korean Med Ophtalmol Otolaryngol Dermatol. 2008;21(2):184-90.
  13. Kim HS, Choi JE, Yoo HS. The Effectiveness of Gargling Hwangryunhaedok-tang on Chemotherapy-Induced Stomatitis. J of Kor. Traditional Oncology. 2011;16(1):1-14.
  14. Kim JY, Kim JS, Son JH, Seon JK, Kang K, Jang SW, et al. Efficacy of Gamiyukmijihwangtang on Recurrent Aphthous Stomatitis. Korean J Oriental Int Med. 2012;33(2):231-42.
  15. Son CG. Case Report for a Refractory Recurrent Aphthous Stomatitis Treated with Jibaekpalmi-hwon. The Journal of Korean Oriental Medicine. 2012:33(2):73-7.
  16. Cho NK, Lee YR, Choi HS, Kim SM. A Case Report of Chemotherapy-induced Stomatitis Clinically Improved by Acupuncture Treatment. Journal of Korean Traditional Oncology. 2017;22(2):25-31.
  17. Ha NY, Lee JH, Lee JE, Nam SU, Ko WH, Hwang MN. A Follow-up Study of Clinical Characteristics of Recurrent Aphthous Stomatitis Patients Treated with Herbal Medicine. Korean J Oriental Int Med. 2017;38(5):812-9. https://doi.org/10.22246/jikm.2017.38.5.812
  18. Cao Q, Zhang Y, Zeng K. Clinical study on Nourishing Yin Clearing Heat and Detoxification Method in Treatment of Radioactive Stomatitis. Acta Chinese Medicine. 2018;33(5):709-12.
  19. Li W, Zhou Z, Xiao H, Chen Zh. Clinical Study on Radiation Stomatitis Induced by Radiotherapy of Head and Neck Malignant Tumors with Liang Xue Jie Du Decotion. Contemporary Medicine. 2018;24(16):99,100.
  20. Wang H. Clinical Observation on Kouqiangyan Spray Combined with Xiaoer Chiqiao Qingre Granule in the Treatment of Ulcerative Stomatitis. Guangming Traditional Chinese Medicine. 2018;33(15):2258,2259.
  21. Yi K, Wang G. The effects of Qingre Jiedu Method on Epidermal Growth Factors, Inflammatory Factors and Quality of Life of Patients with Acute Stomatitis. Journal of Emergency in Traditional Chinese Medicine. 2018;27(12):2126-8.
  22. Xia T, Xing Y, Li J, Zhang W, Liu J. Effects of Yangyin Qingfei Decoction on Immune Function and Inflammatory Cytokines in Patients with Acute Radioactive Stomatitis. Chinese Medicine Emergency. 2020;29(2):309-11.
  23. Kim TJ, Kim YM, Kim HT. A Case of Recurrent Aphthous Stomatitis Improved by Korean Medical Treatments - Focus on the effectiveness of Chungyeoldodam-tanggagam and Dangguisoo-san Plus Yuhyangjeongtongsangagam. J Korean Med Ophtalmol Otolaryngol Dermatol. 2020;33(2):140-55.
  24. Kim JH. A Case Report of Patient with Recurrent Aphthous Stomatitis and Pompholyx Treated with Modified Palmulgunja-tang. Journal of Sasang Constitutional Medicine. 2020;32(2):80-95.
  25. Liu SX, Wu H, Li Sh, Gao HL, Zhou XY. Clinical Effect of Self-designed Yangyin Qingre Jiedu Recipeon Acute Radiation induced Oral Mucositis. World Journal of Integrated Traditional Chinese and Western Medicine. 2022;17(7):1468-71.
  26. Li Q, Liu Y, Leng X, Zheng Z. Clinical study on prevention and treatment of radiation stomatitis of nasopharyngeal carcinoma with low temperature water extract of Chaxiong. Laboratory Medicine and Clinic. 2022;19(21):2933-6.
  27. Kang WH. Atlas of Skin Disease. Seoul: Hanmibook. 2016:452.
  28. Na JB, Kim HJ, Chae GY, Lee SW, Lee GG, Jang GC, et al. The Effect of Recombinant Human Epidermal Growth Factor on Cisplatin and Radiotherapy Induced Oral Mucositis in Mice. The Journal of the Korean society for therapeutic radiology and oncology. 2007;25(4):242-8.
  29. Gong YB, Kim SC, Park SD, Park SD, Park SG, Seo BI, et al. Bangjehak. Seoul: Younglimsa. 2018:287.
  30. Jung DY, Ha HK, Lee HY, Lee JA, Lee JK, Huang DS, et al. Stimulation of the Immune Response by Yin-Tonifying Formula. J Korean Oriental Med. 2010;31(5):112-23.
  31. Chae BS, Shin TY. Effect of Fresh Rehmanniae Radix Methanol Extracts on the Production of Cytokines. Yakhak Hoeji. 2006;50(3):184-90.
  32. Park YK, Min JY, Lee JH. The Effect of Methyl Gallate Isolated from Paeonia suffruticosa on Inflammatory Response in LPS-stimulated RAW264.7 Cells. Kor. J. Herbology. 2009;24(4):181-8.
  33. Choi SW, Kim EO, Leem HH, Kim JK. Anti-Inflammatory Effects of Volatile Flavor Extracts from Cnidium officinale and Angelica gigas. J Korean Soc Food Sci Nutr. 2012;41(8):1057-65. https://doi.org/10.3746/jkfn.2012.41.8.1057
  34. Kim ES, Chong M. The Anti-depressive Effect of Rehmanniae Radix Preparata via Anti-inflammatory Activity. J Korean Med. 2022;43(1):99-111. https://doi.org/10.13048/jkm.22009
  35. Sung SY, Kook YB. Applications of Prescriptions Including Anemarrhenae Rhizoma and Phellodendri Cortex in Dongeuibogam. The Korean Journal of Oriental Medical Prescription. 2011;19(1):1-22.
  36. Im YG, Park HJ, Lee HS, Im SB, Chae YB, Lee BH, et al. Details of Meridians & Acupoints(Volume I); A Guidebook for College Students. Daejeon:Jongryeonamu. 2016:277-95.
  37. Hong MS, Park HJ, Um YK, Jung KH, Kim SC, Han MY. Microarray profile of hypothalamic gene expression with acupuncture with acupuncture at acupoint ST36 in carrageenan induced inflammation in Stat 6 knockout mice. The Korean Journal of Meridian & Acupoint. 2007;24(2):129-39.
  38. Im YG, Park HJ, Lee HS, Im SB, Chae YB, Lee BH, et al. Details of Meridians & Acupoints(Volume II); A Guidebook for College Students. Daejeon:Jongryeonamu. 2016:580,661-5.