Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Structural Insights for β-Lactam Antibiotics

  • Dogyeoung, Kim (Department of Biological Sciences, Konkuk University) ;
  • Sumin, Kim (Department of Biological Sciences, Konkuk University) ;
  • Yongdae, Kwon (Department of Biological Sciences, Konkuk University) ;
  • Yeseul, Kim (Department of Biological Sciences, Konkuk University) ;
  • Hyunjae, Park (Department of Biological Sciences, Konkuk University) ;
  • Kiwoong, Kwak (Department of Biological Sciences, Konkuk University) ;
  • Hyeonmin, Lee (Department of Biological Sciences, Konkuk University) ;
  • Jung Hun, Lee (National Leading Research Laboratory of Drug Resistance Proteomics, Department of Biological Sciences, Myongji University) ;
  • Kyung-Min, Jang (National Leading Research Laboratory of Drug Resistance Proteomics, Department of Biological Sciences, Myongji University) ;
  • Donghak, Kim (Department of Biological Sciences, Konkuk University) ;
  • Sang Hee, Lee (National Leading Research Laboratory of Drug Resistance Proteomics, Department of Biological Sciences, Myongji University) ;
  • Lin-Woo, Kang (Department of Biological Sciences, Konkuk University)
  • Received : 2023.01.11
  • Accepted : 2023.01.20
  • Published : 2023.03.01
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Abstract

Antibiotic resistance has emerged as a global threat to modern healthcare systems and has nullified many commonly used antibiotics. β-Lactam antibiotics are among the most successful and occupy approximately two-thirds of the prescription antibiotic market. They inhibit the synthesis of the peptidoglycan layer in the bacterial cell wall by mimicking the D-Ala-D-Ala in the pentapeptide crosslinking neighboring glycan chains. To date, various β-lactam antibiotics have been developed to increase the spectrum of activity and evade drug resistance. This review emphasizes the three-dimensional structural characteristics of β-lactam antibiotics regarding the overall scaffold, working mechanism, chemical diversity, and hydrolysis mechanism by β-lactamases. The structural insight into various β-lactams will provide an in-depth understanding of the antibacterial efficacy and susceptibility to drug resistance in multidrug-resistant bacteria and help to develop better β-lactam antibiotics and inhibitors.

Keywords

Acknowledgement

This work was supported by the project 'Development of biomedical materials based on marine proteins' (Project No. 20170305) funded by the Ministry of Oceans and Fisheries, Korea (J.-H.L.). This work was supported by the Bio & Medical Technology Development Program of the National Research Foundation of Korea (NRF), funded by the Ministry of Science and ICT (NRF-2017M3A9E4078014 and NRF-2017M3A9E4078017).

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