CELLMED (셀메드)

Cellmed Orthocellular Medicine and Pharmaceutical Association (셀메드 세포교정의약학회)
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The brand-new compound CPS219 exhibits anti-oxidant and estrogen-like actions

  • Kyung-Min, Jeong (Division of Food and Pharmaceutical Engineering, Hoseo University) ;
  • Yu-Jin, Choi (Division of Food and Pharmaceutical Engineering, Hoseo University) ;
  • Seung-Hwan, Kim (Division of Food and Pharmaceutical Engineering, Hoseo University) ;
  • Hyun-Ja, Jeong (Division of Food and Pharmaceutical Engineering, Hoseo University)
  • Received : 2022.02.14
  • Accepted : 2022.02.28
  • Published : 2023.02.28
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Abstract

CPS219, a new concept compound composed of coffee (CO), Pueraria Tomsonii flower (PF), and Sambou bamboo saltTM (BS), was developed as a coffee beverage to alleviate menopausal symptoms. The purpose of this study is to evaluate the anti-oxidant and menopausal alleviating effects of CPS219 combined as the optimal ratio of each component selected through sensory evaluation and blind consumer test. For CPS219, the optimal ratio of CO, PF, and BS was determined to be 1:0.1:0.017 through various sensory evaluations and blind consumer tests. CPS219 significantly enhanced the superoxide dismutase-like activity compared to the CO or CO plus PF (CP). The proliferation of MCF-7 cells was considerably increased after 24 hours by treatment with CO, CP, or CPS219, but only CPS219 significantly boosted the proliferation of MCF-7 cells after 48 hours. Moreover, CPS219 had an estrogen-like effect by dramatically increasing the expression of estrogen receptor-β mRNA in MCF-7 cells but not CO and CP. Treatment of MCF-7 cells with CO, CP, or CPS219 did not cause any cytotoxicity. In conclusion, these findings imply that anti-oxidant and estrogen-like properties of CPS219 can be used to prevent and cure postmenopausal symptoms.

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References

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