Korean Journal of Clinical Pharmacy (한국임상약학회지)

Korean College Of Clinical Pharmacy (한국임상약학회)
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Risk Factors Associated with Medication Adherence in HIV/AIDS Patients

한국인 HIV/AIDS 환자의 복약순응도에 미치는 위험 인자 연구

  • Kyung Sun Oh (Department of Pharmacy, Inha University Hospital) ;
  • Jin-soo Lee (Infectious Disease, Inha University Hospital) ;
  • Euna Han (College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University)
  • 오경선 (인하대학교병원 약제팀) ;
  • 이진수 (인하대학교병원 감염내과) ;
  • 한은아 (연세대학교 약학대학)
  • Received : 2023.08.28
  • Accepted : 2023.09.27
  • Published : 2023.12.31
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Abstract

Background: Adherence to antiretroviral treatment (ART) is crucial for maintaining the HIV-RNA suppression in patients living with HIV/AIDS. This study aims to analyze the risk factors contributing to low medication adherence among individuals with HIV/AIDS by analyzing data from the Korean HIV/AIDS cohort study. Methods: The dependent variable is ART medication adherence. The depressive symptom and anxiety scores were collected as main independence variables. Covariates included gender, age, transmission route, alcohol and smoking information, and antiviral treatment regimen details. To predict the relationship between ordinal dependent variables and independent variables, an ordered logistic regression analysis was conducted, and odds ratios (OR) were calculated. Results: The results of the ordered logistic regression analysis showed that female was associated with a higher risk of low medication adherence (OR=2.91, 95% CI=1.08, 7.83). Among the subjects who were non-smokers and non-drinkers, the risk of low medication adherence was lower (OR=0.36, 95% CI=0.18, 0.70). Depending on the ART treatment group, individuals taking integrase inhibitor had a lower risk of medication adherence (OR=0.31, 95% CI=0.13, 0.76), and those experiencing depressive symptoms were related with a higher risk of low medication adherence (OR=1.97, 95% CI=1.12, 3.46). Conclusions: The encouragement and emotional support of healthcare professionals are essential for patients living with HIV/AIDS who experience depressive symptoms to maintain ART adherence. Additionally, further research is needed to ensure that HIV/AIDS infected female with concurrent depressive symptoms can achieve appropriate ART therapeutic effect.

Keywords

Acknowledgement

본 연구는 한국 HIV/AIDS cohort study data를 이용하여 분석하였다.

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