International Journal of Oral Biology

  • 제48권4호
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  • Pages.33-44
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  • 2023
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  • 1226-7155(pISSN)
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  • 2287-6618(eISSN)
대한구강생물학회 (The Korean Academy of Oral Biology)
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The role of autophagy in cell proliferation and differentiation during tooth development

  • Ji-Yeon Jung (Dental Science Research Institute, Stem Cell Secretome Research Center, Hard-tissue Biointerface Research Center, Department of Oral Physiology, School of Dentistry, Chonnam National University) ;
  • Shintae Kim (Dental Science Research Institute, Stem Cell Secretome Research Center, Hard-tissue Biointerface Research Center, Department of Oral Physiology, School of Dentistry, Chonnam National University) ;
  • Yeon-Woo Jeong (Dental Science Research Institute, Stem Cell Secretome Research Center, Hard-tissue Biointerface Research Center, Department of Oral Physiology, School of Dentistry, Chonnam National University) ;
  • Won-Jae Kim (Dental Science Research Institute, Stem Cell Secretome Research Center, Hard-tissue Biointerface Research Center, Department of Oral Physiology, School of Dentistry, Chonnam National University)
  • 투고 : 2023.09.06
  • 심사 : 2023.09.21
  • 발행 : 2023.12.31
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초록

In this review, the regulatory mechanisms of autophagy were described, and its interaction with apoptosis was identified. The role of autophagy in embryogenesis, tooth development, and cell differentiation were also investigated. Autophagy is regulated by various autophagy-related genes and those related to stress response. Highly active autophagy occurrences have been reported during cell differentiation before implantation after fertilization. Autophagy is involved in energy generation and supplies nutrients during early birth, essential to compensate for their deficient supply from the placenta. The contribution of autophagy during tooth development, such as the shape of the crown and root formation, ivory, and homeostasis in cells, was also observed. Genes control autophagy, and studying the role of autophagy in cell differentiation and development was useful for understanding human aging, illness, and health. In the future, the role of specific mechanisms in the development and differentiation of autophagy may increase the understanding of the pathological mechanisms of disease and development processes and is expected to reduce the treatment of various diseases by modulating the autophagic phenomenon.

키워드

과제정보

This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (2022R1A4A1029312 and 2019R1A5A2027521).

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