대한수의학회지 (Korean Journal of Veterinary Research)

  • 제63권4호
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  • Pages.33.1-33.5
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  • 2023
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  • 2466-1384(pISSN)
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  • 2466-1392(eISSN)
대한수의학회 (The Korean Society of Veterinary Science)
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Screening of the antiparasitic activity of gold nanoparticles on hydatid cysts protoscolices in vitro

  • Sadiya Aziz Anah (Department of Biology, Faculty of Education, University of AL-Qadisiyah)
  • 투고 : 2023.08.18
  • 심사 : 2023.10.15
  • 발행 : 2023.12.31
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초록

Many scolicidal agents have been used to destroy fertile protoscolices, but these scolicidal agents have side effects, highlighting the need for research on effective and non-toxic replacement scolicidal agents. Gold nanoparticles (AuNPs) are biocompatible and non-toxic. The current study examined the effects of AuNPs in killing the protoscolices of Echinococcus granulosus in vitro using eosin staining. The protoscolices were treated with 0.2, 0.4, 0.8, or 1.0 mg/mL of AuNPs for 15, 30, 45, or 60 minutes. A concentration of 1.0 mg/mL was the most efficient in killing the protoscolices after 60 minutes exposure, reaching 96%, followed by 0.8 mg/mL (84.5%), whereas 0.4 and 0.2 mg/mL of AuNPs achieved a death rate of 76.8% and 68.5%, respectively. The loss of the protoscolices was lower at shorter exposure times with the same concentration of AuNPs and increased as the AuNP concentration was increased at the same exposure time. Significant differences were found between the different groups compared to the control group.

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과제정보

The author is thankful to the management of the University of Al-Qadisiyah for their continuous encouragement and support. Funding was provided by author, assist prof. Sadiya Aziz Anah.

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