International Journal of Industrial Entomology and Biomaterials

Korean Society of Sericultural Science (한국잠사학회)
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Effects of Oxya chinensis sinuosa hot water extract on benign prostatic hyperplasia in LNCaP cells

  • Hyun Jung Lim (Department of Agricultural Biology, National Institute of Agricultural Sciences, Rural Development Administration) ;
  • Sohyun Park (Department of Agricultural Biology, National Institute of Agricultural Sciences, Rural Development Administration) ;
  • Ra-Yeong Choi (Department of Agricultural Biology, National Institute of Agricultural Sciences, Rural Development Administration) ;
  • In-Woo Kim (Department of Agricultural Biology, National Institute of Agricultural Sciences, Rural Development Administration) ;
  • Minchul Seo (Department of Agricultural Biology, National Institute of Agricultural Sciences, Rural Development Administration) ;
  • Hae Yong Kweon (Department of Agricultural Biology, National Institute of Agricultural Sciences, Rural Development Administration) ;
  • Joon Ha Lee (Department of Agricultural Biology, National Institute of Agricultural Sciences, Rural Development Administration)
  • Received : 2023.10.30
  • Accepted : 2023.12.07
  • Published : 2023.12.31
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Abstract

In recent years, the number of patients with benign prostatic hyperplasia (BPH), a condition that commonly occurs in elderly men, has increased due to aging and the adoption of western dietary habits. Treatment with chemical drugs, such as finasteride or dutasteride, can cause side effects such as erectile dysfunction or sexual problems. This necessitates the development of remedies using natural substances derived from food ingredients. In this study, we investigated the inhibitory effects of Oxya chinensis sinuosa hot water extract (OCH) on BPH production in LNCaP cells, a hormone-dependent prostate cancer cell line. We found that the mRNA expression of androgen receptor (AR), prostate specific antigen (PSA), and, 5α-reductases 1, and 2 decreased following treatment with OCH. Furthermore, OCH treatment resulted in reduced protein expression of BPH regulators, such as AR. Collectively, these results suggest that OCH exerts a beneficial effect on BPH by inhibiting the AR signaling pathway, indicating the potential of OCH as a therapeutic agent for the prevention and treatment of BPH.

Keywords

Acknowledgement

This study was supported by the Cooperative Research Program for Agriculture Science and Technology Development (Project no. PJ01563202), Rural Development Administration, Republic of Korea.

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