International Journal of Industrial Entomology and Biomaterials

  • 제47권2호
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  • Pages.90-98
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  • 2023
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  • 3022-7542(pISSN)
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  • 2586-4785(eISSN)
한국잠사학회 (Korean Society of Sericultural Science)
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Protective effect of Oxya chinensis sinuosa methanol extract on UVB-induced damage in human retinal pigment epithelial cells

  • Hyun Jung Lim (Department of Agricultural Biology, National Institute of Agricultural Sciences, Rural Development Administration) ;
  • Sohyun Park (Department of Agricultural Biology, National Institute of Agricultural Sciences, Rural Development Administration) ;
  • Joon Ha Lee (Department of Agricultural Biology, National Institute of Agricultural Sciences, Rural Development Administration) ;
  • In-Woo Kim (Department of Agricultural Biology, National Institute of Agricultural Sciences, Rural Development Administration) ;
  • HaeYong Kweon (Department of Agricultural Biology, National Institute of Agricultural Sciences, Rural Development Administration) ;
  • Minchul Seo (Department of Agricultural Biology, National Institute of Agricultural Sciences, Rural Development Administration)
  • 투고 : 2023.10.04
  • 심사 : 2023.11.16
  • 발행 : 2023.12.31
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초록

The human eye, constantly exposed to solar radiation, can be damaged by UV radiation. In particular, ultraviolet B (UVB)-induced damage plays an important role in retinal degeneration and cell aging. In this study, we investigated the protective effects of the methanol extract of Oxya chinensis sinuosa (OCM), an edible insect known for its high protein content (64.2%), and various pharmacological effects, on human retinal pigment epithelial cells. ARPE-19 cells were treated with OCM and subsequently UVB irradiated. Our results showed that OCM effectively attenuates UVB-induced cell damage by reducing MAPK phosphorylation (JNK and p38 MAPK). Additionally, OCM increased the phosphorylation of Akt, and cell cycle regulators, including p21 and p27, in a dose-dependent manner. Moreover, OCM treatment increased ARPE-19 cell proliferation by activating the S6K1/S6 pathway. This study suggests that OCM prevents UVB-induced retinal cell damage by increasing cell proliferation via ROS reduction, suggesting its potential as a functional therapeutic superfood against retinal cell damage.

키워드

과제정보

This work was supported by Rural Development Administration, Republic of Korea (Project no. PJ01563201)

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