Journal of Biomedical Engineering Research (대한의용생체공학회:의공학회지)

The Korean Society of Medical and Biological Engineering (대한의용생체공학회)
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A Simple Design of an Imaging System for Accurate Spatial Mapping of Blood Oxygen Saturation Using a Single Element of Multi-wavelength LED

혈중 산소 포화도의 정확한 공간 매핑을 위한 다중 파장 LED 단일소자를 활용한 이미징 시스템 설계

  • Jun Hwan Kim (Department of Biomedical Engineering, Yonsei University) ;
  • Gi Yeon Yu (Department of Biomedical Engineering, Yonsei University) ;
  • Ye Eun Song (Department of Biomedical Engineering, Yonsei University) ;
  • Chan Yeong Yu (Department of Biomedical Engineering, Yonsei University) ;
  • Yun Chae Jang (Department of Biomedical Engineering, Yonsei University) ;
  • Riaz Muhammad (Department of Biomedical Engineering, Yonsei University) ;
  • Kay Thwe Htun (Department of Biomedical Engineering, Yonsei University) ;
  • Ahmed Ali (Department of Biomedical Engineering, Yonsei University) ;
  • Seung Ho Choi (Department of Biomedical Engineering, Yonsei University)
  • 김준환 (연세대학교 미래캠퍼스 의공학부) ;
  • 유기연 (연세대학교 미래캠퍼스 의공학부) ;
  • 송예은 (연세대학교 미래캠퍼스 의공학부) ;
  • 유찬영 (연세대학교 미래캠퍼스 의공학부) ;
  • 장윤채 (연세대학교 미래캠퍼스 의공학부) ;
  • 무하마드 리아즈 (연세대학교 미래캠퍼스 의공학부) ;
  • 케이 뜨웨 툰 (연세대학교 미래캠퍼스 의공학부) ;
  • 아메드 알리 (연세대학교 미래캠퍼스 의공학부) ;
  • 최승호 (연세대학교 미래캠퍼스 의공학부)
  • Received : 2023.12.03
  • Accepted : 2023.12.16
  • Published : 2023.12.31
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Abstract

Pulse oximetry, a non-invasive technique for evaluating blood oxygen saturation, conventionally depends on isolated measurements, rendering it vulnerable to factors like illumination profile, spatial blood flow fluctuations, and skin pigmentation. Previous efforts to address these issues through imaging systems often employed red and near-infrared illuminations with distinct profiles, leading to inconsistent ratios of transmitted light and the potential for errors in calculating spatial oxygen saturation distributions. While an integrating sphere was recently utilized as an illumination source to achieve uniform red and near-infrared illumination profiles on the sample surface, its bulkiness presented practical challenges. In this work, we have enhanced the pulse oximetry imaging system by transitioning illumination from an integrating sphere to a multi-wavelength LED configuration. This adjustment ensures simultaneous emission of red and near-infrared light from the same position, creating a homogeneous illumination profile on the sample surface. This approach guarantees consistent patterns of red and near-infrared illuminations that are spatially uniform. The sustained ratio between transmitted red and near-infrared light across space enables precise calculation of the spatial distribution of oxygen saturation, making our pulse oximetry imaging system more compact and portable without compromising accuracy. Our work significantly contributes to obtaining spatial information on blood oxygen saturation, providing valuable insights into tissue oxygenation in peripheral regions.

Keywords

Acknowledgement

This work was supported by the National Research Foundation of Korea (NRF), grant-funded by the Korean government (MSIT) (No. 2022R1C1C1011328; 2022H1D3A2A02081592) and the Brain Korea 21 Four Program. This research was also supported by "Regional Innovation Strategy (RIS)" through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (MOE) in 2023 (2022RIS-005). This work was also carried out with the support of "Cooperative Research Program for Agriculture Science & Technology Development (Project No. PJ015373)" Rural Development Administration, Republic of Korea.

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