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The Effect of Health Functional Food on Body Weight Reduction

건강기능식품의 체중 감량 효과

  • Joo, Nam-Seok (Department of Family Practice and Community Health, Ajou University School of Medicine)
  • 주남석 (아주대학교병원 가정의학과)
  • Received : 2022.11.28
  • Accepted : 2022.12.13
  • Published : 2022.12.31

Abstract

Obesity is a serious health concern, which has been linked to an increased risk for cardiovascular diseases and some cancers. The traditional obesity control program is expensive. Moreover, it is difficult to maintain a healthy body weight as well as reduce body fat. The long-term use of effective and tolerable medication is carefully recommended to control body weight. In addition to obesity control medications, health functional foods, related to body weight control, have become popular in the commercial market. Known mechanisms include lipolysis, appetite control, inflammation reduction, and lean body mass maintenance. Previous clinical trials have documented the efficacy of some health functional foods; however, there are limitations. Studies on the potential roles and efficacy of some health functional foods, including caffeine, green tea, protein supplement, probiotics, and arginine, were reviewed. More large-scale and randomized placebo-controlled trials should be conducted eventually.

Keywords

References

  1. Guh DP, Zhang W, Bansback N, Amarsi Z, Birmingham CL, Anis AH. The incidence of co-morbidities related to obesity and overweight: a systematic review and meta-analysis. BMC Public Health 2009;9:88. https://doi.org/10.1186/1471-2458-9-88
  2. Srivastava G, Apovian CM. Current pharmacotherapy for obesity. Nat Rev Endocrinol 2018;14:12-24. https://doi.org/10.1038/nrendo.2017.122
  3. Patti ME, Kahn BB. Nutrient sensor links obesity with diabetes risk. Nat Med 2004;10:1049-50. https://doi.org/10.1038/nm1004-1049
  4. Liu AG, Smith SR, Fujioka K, Greenway FL. The effect of leptin, caffeine/ephedrine, and their combination upon visceral fat mass and weight loss. Obesity (Silver Spring) 2013;21:1991-6. https://doi.org/10.1002/oby.20416
  5. Ohara T, Muroyama K, Yamamoto Y, Murosaki S. Oral intake of a combination of glucosyl hesperidin and caffeine elicits an anti-obesity effect in healthy, moderately obese subjects: a randomized double-blind placebo-controlled trial. Nutr J 2016;15:6.
  6. Green RM, Stiles GL. Chronic caffeine ingestion sensitizes the A1 adenosine receptor-adenylate cyclase system in rat cerebral cortex. J Clin Invest 1986;77:222-7. https://doi.org/10.1172/JCI112280
  7. Goldberg MR, Curatolo PW, Tung CS, Robertson D. Caffeine down-regulates beta adrenoreceptors in rat forebrain. Neurosci Lett 1982;31:47-52. https://doi.org/10.1016/0304-3940(82)90052-0
  8. Virmani MA, Cirulli M. The role of l-carnitine in mitochondria, prevention of metabolic inflexibility and disease initiation. Int J Mol Sci 2022;23:2717. https://doi.org/10.3390/ijms23052717
  9. Baghban F, Hosseinzadeh M, Mozaffari-Khosravi H, Dehghan A, Fallahzadeh H. The effect of L-Carnitine supplementation on clinical symptoms, C-reactive protein and malondialdehyde in obese women with knee osteoarthritis: a double blind randomized controlled trial. BMC Musculoskelet Disord 2021;22:195. https://doi.org/10.1186/s12891-021-04059-1
  10. El Sharkwy I, Sharaf El-Din M. l-Carnitine plus metformin in clomiphene-resistant obese PCOS women, reproductive and metabolic effects: a randomized clinical trial. Gynecol Endocrinol 2019;35:701-5. https://doi.org/10.1080/09513590.2019.1576622
  11. van Marken Lichtenbelt WD, Vanhommerig JW, Smulders NM, et al. Cold-activated brown adipose tissue in healthy men. N Engl J Med 2009;360:1500-8. https://doi.org/10.1056/NEJMoa0808718
  12. Yoneshiro T, Aita S, Matsushita M, et al. Brown adipose tissue, whole-body energy expenditure, and thermogenesis in healthy adult men. Obesity (Silver Spring) 2011;19:13-6. https://doi.org/10.1038/oby.2010.105
  13. Schulz TJ, Huang P, Huang TL, et al. Brown-fat paucity due to impaired BMP signalling induces compensatory browning of white fat. Nature 2013;495:379-83. https://doi.org/10.1038/nature11943
  14. Maeda H, Hosokawa M, Sashima T, Funayama K, Miyashita K. Fucoxanthin from edible seaweed, Undaria pinnatifida, shows antiobesity effect through UCP1 expression in white adipose tissues. Biochem Biophys Res Commun 2005;332:392-7. https://doi.org/10.1016/j.bbrc.2005.05.002
  15. Kim KM, Kim SM, Cho DY, Park SJ, Joo NS. The effect of xanthigen on the expression of brown adipose tissue assessed by 18F-FDG PET. Yonsei Med J 2016;57:1038-41. https://doi.org/10.3349/ymj.2016.57.4.1038
  16. Koo SY, Hwang JH, Yang SH, et al. Anti-obesity effect of standardized extract of microalga Phaeodactylum tricornutum containing fucoxanthin. Mar Drugs 2019;17:311. https://doi.org/10.3390/md17050311
  17. Agatonovic-Kustrin S, Kustrin E, Gegechkori V, Morton DW. High-performance thin-layer chromatography hyphenated with microchemical and biochemical derivatizations in bioactivity profiling of marine species. Mar Drugs 2019;17:148. https://doi.org/10.3390/md17030148
  18. Hu J, Webster D, Cao J, Shao A. The safety of green tea and green tea extract consumption in adults - results of a systematic review. Regul Toxicol Pharmacol 2018;95:412-33. https://doi.org/10.1016/j.yrtph.2018.03.019
  19. Wang S, Moustaid-Moussa N, Chen L, et al. Novel insights of dietary polyphenols and obesity. J Nutr Biochem 2014;25:1-18. https://doi.org/10.1016/j.jnutbio.2013.09.001
  20. Gu Q, Wang X, Xie L, et al. Green tea catechin EGCG could prevent obesity-related precocious puberty through NKB/NK3R signaling pathway. J Nutr Biochem 2022;108:109085. https://doi.org/10.1016/j.jnutbio.2022.109085
  21. Dostal AM, Arikawa A, Espejo L, Kurzer MS. Long-term supplementation of green tea extract does not modify adiposity or bone mineral density in a randomized trial of overweight and obese postmenopausal women. J Nutr 2016;146:256-64. https://doi.org/10.3945/jn.115.219238
  22. Xie L, Tang Q, Yao D, et al. Effect of decaffeinated green tea polyphenols on body fat and precocious puberty in obese girls: a randomized controlled trial. Front Endocrinol (Lausanne) 2021;12:736724. https://doi.org/10.3389/fendo.2021.736724
  23. Yoshitomi R, Yamamoto M, Kumazoe M, et al. The combined effect of green tea and α-glucosyl hesperidin in preventing obesity: a randomized placebo-controlled clinical trial. Sci Rep 2021;11:19067. https://doi.org/10.1038/s41598-021-98612-6
  24. Samaha FF, Iqbal N, Seshadri P, et al. A low-carbohydrate as compared with a low-fat diet in severe obesity. N Engl J Med 2003;348:2074-81. https://doi.org/10.1056/NEJMoa022637
  25. Joo NS, Park YW, Park KH, Kim CW, Kim BT. Application of Protein-Rich Oriental Diet in a community-based obesity control program. Yonsei Med J 2011;52:249-56. https://doi.org/10.3349/ymj.2011.52.2.249
  26. Kang Y, Kim N, Choi YJ, et al. Leucine-enriched protein supplementation increases lean body mass in healthy Korean adults aged 50 years and older: a randomized, double-blind, placebo-controlled trial. Nutrients 2020;12:1816. https://doi.org/10.3390/nu12061816
  27. Ooi DSQ, Ling JQR, Ong FY, et al. Branched chain amino acid supplementation to a hypocaloric diet does not affect resting metabolic rate but increases postprandial fat oxidation response in overweight and obese adults after weight loss intervention. Nutrients 2021;13:4245. https://doi.org/10.3390/nu13124245
  28. Li F, Hsueh YT, Hsu Y, et al. Effects of isolated soy protein supplementation combined with aerobic exercise training on improving body composition, anthropometric characteristics and cardiopulmonary endurance in women: a pilot study. Int J Environ Res Public Health. 2021;18:11798. https://doi.org/10.3390/ijerph182211798
  29. Martin CR, Osadchiy V, Kalani A, Mayer EA. The brain-gut-microbiome axis. Cell Mol Gastroenterol Hepatol 2018;6:133-48. https://doi.org/10.1016/j.jcmgh.2018.04.003
  30. Chambers ES, Morrison DJ, Frost G. Control of appetite and energy intake by SCFA: what are the potential underlying mechanisms? Proc Nutr Soc 2015;74:328-36. https://doi.org/10.1017/S0029665114001657
  31. Ryu JY, Choi HM, Yang HI, Kim KS. Dysregulated autophagy mediates sarcopenic obesity and its complications via AMPK and PGC1α signaling pathways: potential involvement of gut dysbiosis as a pathological link. Int J Mol Sci 2020;21:6887. https://doi.org/10.3390/ijms21186887
  32. Lim S, Moon JH, Shin CM, Jeong D, Kim B. Effect of Lactobacillus sakei, a probiotic derived from Kimchi, on body fat in Koreans with obesity: a randomized controlled study. Endocrinol Metab (Seoul) 2020;35:425-34. https://doi.org/10.3803/EnM.2020.35.2.425
  33. Rondanelli M, Miraglia N, Putignano P, et al. Effects of 60-day Saccharomyces boulardii and superoxide dismutase supplementation on body composition, hunger sensation, pro/antioxidant ratio, inflammation and hormonal lipo-metabolic biomarkers in obese adults: a double-blind, placebo-controlled trial. Nutrients 2021;13:2512. https://doi.org/10.3390/nu13082512
  34. Cho YG, Yang YJ, Yoon YS, et al. Effect of MED-02 containing two probiotic strains, Limosilactobacillus fermentum MG4231 and MG4244, on body fat reduction in overweight or obese subjects: a randomized, multicenter, double-blind, placebo-controlled study. Nutrients 2022;14:3583. https://doi.org/10.3390/nu14173583
  35. Jobgen WS, Fried SK, Fu WJ, Meininger CJ, Wu G. Regulatory role for the arginine-nitric oxide pathway in metabolism of energy substrates. J Nutr Biochem 2006;17:571-88. https://doi.org/10.1016/j.jnutbio.2005.12.001
  36. Nevzati E, Shafighi M, Bakhtian KD, Treiber H, Fandino J, Fathi AR. Estrogen induces nitric oxide production via nitric oxide synthase activation in endothelial cells. Acta Neurochir Suppl 2015;120:141-5. https://doi.org/10.1007/978-3-319-04981-6_24
  37. Kozakowski J, Gietka-Czernel M, Leszczynska D, Majos A. Obesity in menopause - our negligence or an unfortunate inevitability? Prz Menopauzalny 2017;16:61-5.
  38. Mousavi SM, Milajerdi A, Fatahi S, et al. The effect of L-arginine supplementation on obesity-related indices: a systematic review and meta-analysis of randomized clinical trials. Int J Vitam Nutr Res 2021;91:164-74. https://doi.org/10.1024/0300-9831/a000523
  39. Folope V, Meret C, Castres I, et al. Evaluation of a supervised adapted physical activity program associated or not with oral supplementation with arginine and leucine in subjects with obesity and metabolic syndrome: a randomized controlled trial. Nutrients 2022;14:3708. https://doi.org/10.3390/nu14183708
  40. Joo NS. Obesity management by the approach of functional medicine. Seoul: Daehan Medical Books; 2022.
  41. Blaak EE, Hul G, Verdich C, et al. Fat oxidation before and after a high fat load in the obese insulin-resistant state. J Clin Endocrinol Metab 2006;91:1462-9. https://doi.org/10.1210/jc.2005-1598
  42. Kim BR, Seo JW, Kim SM, Kim KN, Joo NS. The presence of urinary ketones according to metabolic status and obesity. J Korean Med Sci 2020;35:e273. https://doi.org/10.3346/jkms.2020.35.e273
  43. Kim HJ, Joo NS, Kim KM, Lee DJ, Kim SM. Different response of body weight change according to ketonuria after fasting in the healthy obese. J Korean Med Sci 2012;27:250-4. https://doi.org/10.3346/jkms.2012.27.3.250
  44. Weindruch R. Caloric restriction and aging. Sci Am 1996;274:46-52. https://doi.org/10.1038/scientificamerican0196-46
  45. Burgos-Moron E, Abad-Jimenez Z, Maranon AM, et al. Relationship between oxidative stress, ER stress, and inflammation in type 2 diabetes: the battle continues. J Clin Med 2019;8:1385. https://doi.org/10.3390/jcm8091385
  46. Joo NS. Clinical functional medicine. Seoul: Doctors Book; 2022.
  47. Yeum KJ, Dawson-Hughes B, Joo NS. Fat mass is associated with serum 25-hydroxyvitamin D concentration regardless of body size in men. Nutrients 2018;10:850. https://doi.org/10.3390/nu10070850
  48. Migliaccio S, Di Nisio A, Mele C, Scappaticcio L, Savastano S, Colao A; Obesity Programs of nutrition, Education, Research and Assessment (OPERA) Group. Obesity and hypovitaminosis D: causality or casualty? Int J Obes Suppl 2019;9:20-31. https://doi.org/10.1038/s41367-019-0010-8
  49. Salehpour A, Hosseinpanah F, Shidfar F, et al. A 12-week double-blind randomized clinical trial of vitamin D3 supplementation on body fat mass in healthy overweight and obese women. Nutr J 2012;11:78. https://doi.org/10.1186/1475-2891-11-78
  50. Gallagher JC, Sai A, Templin T 2nd, Smith L. Dose response to vitamin D supplementation in postmenopausal women: a randomized trial. Ann Intern Med 2012;156:425-37. https://doi.org/10.7326/0003-4819-156-6-201203200-00005
  51. D'Angelo S, Motti ML, Meccariello R. ω-3 and ω-6 polyunsaturated fatty acids, obesity and cancer. Nutrients 2020;12:2751. https://doi.org/10.3390/nu12092751
  52. Salman HB, Salman MA, Yildiz Akal E. The effect of omega-3 fatty acid supplementation on weight loss and cognitive function in overweight or obese individuals on weight-loss diet. Nutr Hosp 2022;39:803-13.
  53. Meyer-Gerspach AC, Hafliger S, Meili J, et al. Effect of L-tryptophan and L-leucine on gut hormone secretion, appetite feelings and gastric emptying rates in lean and non-diabetic obese participants: a randomized, double-blind, parallel-group trial. PLoS One 2016;11:e0166758. https://doi.org/10.1371/journal.pone.0166758