Acknowledgement
This study was supported by Youth Program of the National Natural Science Foundation of China (#32000953), Department of Finance of Jilin Province (#3D5197434429), Health Commission of Jilin Province (2021LC019), and the Education Project of Jilin University (#419070600046 and 45121031D024). We thank Prof. Peng Zhao for helping us revise this study.
References
- Nosrati H, Aramideh Khouy R, Nosrati A, Khodaei M, Banitalebi-Dehkordi M, Ashrafi-Dehkordi K, Sanami S, Alizadeh Z. Nanocomposite scaffolds for accelerating chronic wound healing by enhancing angiogenesis. J Nanobiotechnol 2021;19(1):1. https://doi.org/10.1186/s12951-020-00755-7
- Veith AP, Henderson K, Spencer A, Sligar AD, Baker AB. Therapeutic strategies for enhancing angiogenesis in wound healing. Adv Drug Deliv Rev 2019;146: 97-125. https://doi.org/10.1016/j.addr.2018.09.010
- Xue M, Zhao R, March L, Jackson CJ. Dermal fibroblast heterogeneity and its contribution to the skin repair and regeneration. Adv Wound Care 2021;11(2):87-107.
- Rong X, Li J, Yang Y, Shi L, Jiang T. Human fetal skin-derived stem cell secretome enhances radiation-induced skin injury therapeutic effects by promoting angiogenesis. Stem Cell Res Ther 2019;10(1):383. https://doi.org/10.1186/s13287-019-1456-x
- Rong X, Chu W, Zhang H, Wang Y, Qi X, Zhang G, Wang Y, Li C. Antler stem cell-conditioned medium stimulates regenerative wound healing in rats. Stem Cell Res Ther 2019;10(1):326. https://doi.org/10.1186/s13287-019-1457-9
- Xu X, Li X, Zhang L, Liu Z, Pan Y, Chen D, Bin D, Deng Q, Sun Y, Hoffman RM, Yang Z, Yuan H. Enhancement of wound healing by the traditional Chinese medicine herbal mixture Sophora flavescens in a rat model of perianal ulceration. Vivo 2017;31(4):543-9. https://doi.org/10.21873/invivo.11092
- Sugimoto T, Tsunoda A, Kano N, Kashiwagura Y, Hirose K-i, Sasaki T. A randomized, prospective, double-blind, placebo-controlled trial of the effect of diltiazem gel on pain after hemorrhoidectomy. World J Surg 2013;37(10): 2454-7. https://doi.org/10.1007/s00268-013-2124-4
- Homaeigohar S, Boccaccini AR. Antibacterial biohybrid nanofibers for wound dressings. Acta Biomater 2020;107:25-49. https://doi.org/10.1016/j.actbio.2020.02.022
- Miguel SP, Sequeira RS, Moreira AF, Cabral CSD, Mendonca AG, Ferreira P, Correia IJ. An overview of electrospun membranes loaded with bioactive molecules for improving the wound healing process. Eur J Pharm Biopharm 2019;139:1-22. https://doi.org/10.1016/j.ejpb.2019.03.010
- Kim HS, Sun X, Lee J-H, Kim H-W, Fu X, Leong KW. Advanced drug delivery systems and artificial skin grafts for skin wound healing. Adv Drug Deliv Rev 2019;146:209-39. https://doi.org/10.1016/j.addr.2018.12.014
- Vijayakumar V, Samal SK, Mohanty S, Nayak SK. Recent advancements in biopolymer and metal nanoparticle-based materials in diabetic wound healing management. Int J Biol Macromol 2019;122:137-48. https://doi.org/10.1016/j.ijbiomac.2018.10.120
- Sturkie EK, Moore CR, Caulfield CA, Schmid E, Lachiewicz AM, Stephens JR. Frequency and yield of blood cultures for observation patients with skin and soft tissue infections. Am J Emerg Med 2021;44:161-5. https://doi.org/10.1016/j.ajem.2021.02.026
- Sun M, Ye Y, Xiao L, Duan X, Zhang Y, Zhang H. Anticancer effects of ginsenoside Rg3 (review). Int J Mol Med 2017;39(3):507-18. https://doi.org/10.3892/ijmm.2017.2857
- Zhang K, Liu Y, Wang C, Li J, Xiong L, Wang Z, Liu J, Li P. Evaluation of the gastroprotective effects of 20 (S)-ginsenoside Rg3 on gastric ulcer models in mice. J Ginseng Res 2019;43(4):550-61. https://doi.org/10.1016/j.jgr.2018.04.001
- Lim T-G, Lee CC, Dong Z, Lee KW. Ginsenosides and their metabolites: a review of their pharmacological activities in the skin. Arch Dermatol Res 2015;307(5):397-403. https://doi.org/10.1007/s00403-015-1569-8
- Qiu R, Qian F, Wang X, Li H, Wang L. Targeted delivery of 20(S)-ginsenoside Rg3-based polypeptide nanoparticles to treat colon cancer. Biomed Microdevices 2019;21(1):18. https://doi.org/10.1007/s10544-019-0374-0
- Cheng L, Sun X, Hu C, Jin R, Sun B, Shi Y, Cui W, Zhang Y. In vivo early intervention and the therapeutic effects of 20(S)-Ginsenoside Rg3 on hypertrophic scar formation. PLoS One 2014;9(12):e113640. https://doi.org/10.1371/journal.pone.0113640
- Cheng L, Sun X, Hu C, Jin R, Sun B, Shi Y, Zhang L, Cui W, Zhang Y. In vivo inhibition of hypertrophic scars by implantable ginsenoside-Rg3-loaded electrospun fibrous membranes. Acta Biomater 2013;9(12):9461-73. https://doi.org/10.1016/j.actbio.2013.07.040
- Bai H, Kyu-Cheol N, Wang Z, Cui Y, Liu H, Liu H, Feng Y, Zhao Y, Lin Q, Li Z. Regulation of inflammatory microenvironment using a self-healing hydrogel loaded with BM-MSCs for advanced wound healing in rat diabetic foot ulcers. J Tissue Eng 2020;11. 2041731420947242.
- Liu H, Zhu X, Guo H, Huang H, Huang S, Huang S, Xue W, Zhu P, Guo R. Nitric oxide released injectable hydrogel combined with synergistic photothermal therapy for antibacterial and accelerated wound healing. Appl Mater Today 2020;20:100781. https://doi.org/10.1016/j.apmt.2020.100781
- Pescatori M. Closed vs. open hemorrhoidectomy: associated sphincterotomy and postoperative bleeding. Dis Colon Rectum 2000;43(8):1174-5. https://doi.org/10.1007/BF02236571
- Sugimoto T, Tsunoda A, Kano N, Kashiwagura Y, Hirose K, Sasaki T. A randomized, prospective, double-blind, placebo-controlled trial of the effect of diltiazem gel on pain after hemorrhoidectomy. World J Surg 2013;37(10): 2454-7. https://doi.org/10.1007/s00268-013-2124-4
- Su T, Yang B, Gao T, Liu T, Li J. Polymer nanoparticle-assisted chemotherapy of pancreatic cancer. Therap Adv Med Oncol 2020;12. 1758835920915978.
- Qiu R, Sun D, Bai Y, Li J, Wang L. Application of tumor-targeting peptidedecorated polypeptide nanoparticles with doxorubicin to treat osteosarcoma. Drug Deliv 2020;27(1):1704-17. https://doi.org/10.1080/10717544.2020.1856221
- Li J, Xu W, Li D, Liu T, Zhang YS, Ding J, Chen X. Locally deployable nanofiber patch for sequential drug delivery in treatment of primary and advanced orthotopic hepatomas. ACS Nano 2018;12(7):6685-99. https://doi.org/10.1021/acsnano.8b01729
- Li J, Xu W, Chen J, Li D, Zhang K, Liu T, Ding J, Chen X. Highly bioadhesive polymer membrane continuously releases cytostatic and anti-inflammatory drugs for peritoneal adhesion prevention. ACS Biomater Sci Eng 2018;4(6): 2026-36. https://doi.org/10.1021/acsbiomaterials.7b00605
- Qiu H, Guo H, Li D, Hou Y, Kuang T, Ding J. Intravesical hydrogels as drug reservoirs. Trends Biotechnol 2020;38(6):579-83. https://doi.org/10.1016/j.tibtech.2019.12.012
- Zheng Y, Cheng Y, Chen J, Ding J, Li M, Li C, Wang J-c, Chen X. Injectable hydrogel-microsphere construct with sequential degradation for locally synergistic chemotherapy. ACS Appl Mater Interfaces 2017;9(4):3487-96. https://doi.org/10.1021/acsami.6b15245
- Liu H, Wang C, Li C, Qin Y, Wang Z, Yang F, Li Z, Wang J. A functional chitosanbased hydrogel as a wound dressing and drug delivery system in the treatment of wound healing. RSC Adv 2018;8(14):7533-49. https://doi.org/10.1039/C7RA13510F
- Boateng JS, Matthews KH, Stevens HNE, Eccleston GM. Wound healing dressings and drug delivery systems: a review. J Pharmaceut Sci 2008;97(8): 2892-923. https://doi.org/10.1002/jps.21210
- Yao Y, Zhang A, Yuan C, Chen X, Liu Y. Recent trends on burn wound care: hydrogel dressings and scaffolds. Biomater Sci 2021;9(13):4523-40. https://doi.org/10.1039/D1BM00411E
- Sulastri E, Lesmana R, Zubair MS, Elamin KM, Wathoni N. A comprehensive review on ulvan based hydrogel and its biomedical applications. Chem Pharmaceut Bull 2021;69(5):432-43. https://doi.org/10.1248/cpb.c20-00763
- Hawthorne B, Simmons JK, Stuart B, Tung R, Zamierowski DS, Mellott AJ. Enhancing wound healing dressing development through interdisciplinary collaboration. J Biomed Mater Res B Appl Biomater 2021;109(12):1967-85. https://doi.org/10.1002/jbm.b.34861
- Xu Z, Liang B, Tian J, Wu J. Anti-inflammation biomaterial platforms for chronic wound healing. Biomater Sci 2021;9(12):4388-409. https://doi.org/10.1039/D1BM00637A
- Ostadkarampour M, Putnins EE. Monoamine oxidase inhibitors: a review of their anti-inflammatory therapeutic potential and mechanisms of action. Front Pharmacol 2021;12:676239. https://doi.org/10.3389/fphar.2021.676239
- Rose-John S. Therapeutic targeting of IL-6 trans-signaling. Cytokine 2021;144: 155577. https://doi.org/10.1016/j.cyto.2021.155577
- Radovic K, Brkovic B, Roganovic J, Ilic J, Milic Lemic A, Jovanovic B. Salivary VEGF and post-extraction wound healing in type 2 diabetic immediate denture wearers. Acta Odontol Scand 2021;80(1):9-14.
- Brinkmann A, Winkelmann K, Kaeckenmeister T, Roider J, Klettner A. Effect of long-term anti-VEGF treatment on viability and function of RPE cells. Curr Eye Res 2021;47(1):127-34.
- Chung M-Y, Jung SK, Lee H-J, Shon DH, Kim H-K. Ethanol extract of sarcodon asparatus mitigates inflammatory responses in lipopolysaccharide-challenged mice and murine macrophages. J Med Food 2015;18(11):1198-206. https://doi.org/10.1089/jmf.2014.3422
- Xie P, Jia S, Tye R, Xu W, Zhong A, Hong SJ, Galiano RD, Mustoe TA. Topical administration of oxygenated hemoglobin improved wound healing in an ischemic rabbit ear model. Plast Reconstr Surg 2016;137(2):534-43. https://doi.org/10.1097/01.prs.0000475763.94203.52
- Maeda T, Yamamoto T, Imamura T, Tsuboi R. Impaired wound healing in bleomycin-induced murine scleroderma: a new model of wound retardation. Arch Dermatol Res 2016;308(2):87-94. https://doi.org/10.1007/s00403-015-1614-7
- Chakrabarti S, Mazumder B, Rajkonwar J, Pathak MP, Patowary P, Chattopadhyay P. bFGF and collagen matrix hydrogel attenuates burn wound inflammation through activation of ERK and TRK pathway. Sci Rep 2021;11(1):3357. https://doi.org/10.1038/s41598-021-82888-9