과제정보
This work was supported by the Korean Society of Ginseng funded by the Korea Ginseng Cooperation (2019) and by the National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (No. NRF-2018R1A5A2023127).
참고문헌
- Bandelow B, Michaelis S. Epidemiology of anxiety disorders in the 21st century. Dialogues Clin Neurosci 2015;17:327-35. https://doi.org/10.31887/DCNS.2015.17.3/bbandelow
- Gottschalk MG, Domschke K. Genetics of generalized anxiety disorder and related traits. Dialogues Clin Neurosci 2017;19:159-68. https://doi.org/10.31887/DCNS.2017.19.2/kdomschke
- Viggiano A, Cacciola G, Widmer DA, Viggiano D. Anxiety as a neurodevelopmental disorder in a neuronal subpopulation: evidence from gene expression data. Psychiatry Res 2015;228:729-40. https://doi.org/10.1016/j.psychres.2015.05.032
- Bandelow B, Michaelis S, Wedekind D. Treatment of anxiety disorders. Dialogues Clin Neurosci 2017;19:93-107. https://doi.org/10.31887/DCNS.2017.19.2/bbandelow
- Blanco C, Raza MS, Schneier FR, Liebowitz MR. The evidence-based pharmacological treatment of social anxiety disorder. Int J Neuropsychopharmacol 2003;6:427-42. https://doi.org/10.1017/S1461145703003791
- Jeong HG, Ko YH, Oh SY, Han C, Kim T, Joe SH. Effect of Korean Red Ginseng as an adjuvant treatment for women with residual symptoms of major depression. Asia Pac Psychiatry 2015;7:330-6. https://doi.org/10.1111/appy.12169
- Kim Y, Cho SH. The effect of ginsenosides on depression in preclinical studies: a systematic review and meta-analysis. J Ginseng Res 2021;45:420-32. https://doi.org/10.1016/j.jgr.2020.08.006
- Bhattacharya SK, Mitra SK. Anxiolytic activity of Panax ginseng roots: an experimental study. J Ethnopharmacol 1991;34:87-92. https://doi.org/10.1016/0378-8741(91)90193-H
- Park JH, Cha HY, Seo JJ, Hong JT, Han K, Oh KW. Anxiolytic-like effects of ginseng in the elevated plus-maze model: comparison of red ginseng and sun ginseng. Prog Neuropsychopharmacol Biol Psychiatry 2005;29:895-900. https://doi.org/10.1016/j.pnpbp.2005.04.016
- Zhao Z, Kim YW, Wu Y, Zhang J, Lee JH, Li X, Cho IJ, Park SM, Jung DH, Yang CH, et al. Korean Red Ginseng attenuates anxiety-like behavior during ethanol withdrawal in rats. J Ginseng Res 2014;38:256-63. https://doi.org/10.1016/j.jgr.2014.05.010
- Kim TW, Choi HJ, Kim NJ, Kim DH. Anxiolytic-like effects of ginsenosides Rg3 and Rh2 from red ginseng in the elevated plus-maze model. Planta Med 2009;75:836-9. https://doi.org/10.1055/s-0029-1185402
- Mohler H. The GABA system in anxiety and depression and its therapeutic potential. Neuropharmacology 2012;62:42-53. https://doi.org/10.1016/j.neuropharm.2011.08.040
- Lader M. Benzodiazepine harm: how can it be reduced? Br J Clin Pharmacol 2014;77:295-301. https://doi.org/10.1111/j.1365-2125.2012.04418.x
- _ Zmudzka E, Salaciak K, Sapa J, Pytka K. Serotonin receptors in depression and anxiety: insights from animal studies. Life Sci 2018;210:106-24. https://doi.org/10.1016/j.lfs.2018.08.050
- Graeff FG, Guimar~ aes FS, De Andrade TG, Deakin JF. Role of 5-HT in stress, anxiety, and depression. Pharmacol Biochem Behav 1996;54:129-41. https://doi.org/10.1016/0091-3057(95)02135-3
- Wang GL, He ZM, Zhu HY, Gao YG, Zhao Y, Yang H, Zhang LX. Involvement of serotonergic, noradrenergic and dopaminergic systems in the antidepressantlike effect of ginsenoside Rb1, a major active ingredient of Panax ginseng. C.A. Meyer. J Ethnopharmacol. 2017;204:118-24. https://doi.org/10.1016/j.jep.2017.04.009
- Lee B, Sur B, Lee H, Oh S. Korean Red Ginseng prevents posttraumatic stress disorder-triggered depression-like behaviors in rats via activation of the serotonergic system. J Ginseng Res 2020;44:644-54. https://doi.org/10.1016/j.jgr.2019.09.005
- Lim SW, Doh KC, Jin L, Jin J, Piao SG, Heo SB, Chung BH, Yang CW. Ginseng treatment attenuates autophagic cell death in chronic cyclosporine nephropathy. Nephrology (Carlton). 2014;19:490-9. https://doi.org/10.1111/nep.12273
- Lee MR, Begum S, Sung CK. Effect of red and black ginseng on cholinergic markers, presynaptic markers, and neurotrophins in the brain of aged mice. Food Sci Biotechnol 2017;26:1743-7. https://doi.org/10.1007/s10068-017-0235-7
- Gonzales EL, Jang JH, Mabunga DF, Kim JW, Ko MJ, Cho KS, Bahn GH, Hong M, Ryu JH, Kim HJ, et al. Supplementation of Korean Red Ginseng improves behavior deviations in animal models of autism. Food Nutr Res 2016;60: 29245. https://doi.org/10.3402/fnr.v60.29245
- Abouhosseini Tabari M, Hajizadeh Moghaddam A, Maggi F, Benelli G. Anxiolytic and antidepressant activities of Pelargonium roseum essential oil on Swiss albino mice: possible involvement of serotonergic transmission. Phytother Res 2018;32:1014-22. https://doi.org/10.1002/ptr.6038
- Alonso-Castro AJ, Gasca-Martinez D, Cortez-Mendoza LV, Alba-Betancourt C, Ruiz-Padilla AJ, Zapata-Morales JR. Evaluation of the neuropharmacological effects of Gardenin A in mice. Drug Dev Res 2020;81:600-8. https://doi.org/10.1002/ddr.21659
- Jung JM, Park SJ, Lee YW, Lee HE, Hong SI, Lew JH, Hong E, Shim JS, Cheong JH, Ryu JH. The effects of a standardized Acanthopanax koreanum extract on stress-induced behavioral alterations in mice. J Ethnopharmacol 2013;148: 826-34. https://doi.org/10.1016/j.jep.2013.05.019
- Oh HA, Kim DE, Choi HJ, Kim NJ, Kim DH. Anti-stress effects of 20(S)-protopanaxadiol and 20(S)-protopanaxatriol in immobilized mice. Biol Pharm Bull 2015;38:331-5. https://doi.org/10.1248/bpb.b14-00669
- Dela Pena IJI, Kim HJ, Botanas CJ, de la Pe ~ na JB, Van Le TH, Nguyen MD, Park JH, ~ Cheong JH. The psychopharmacological activities of Vietnamese ginseng in mice: characterization of its psychomotor, sedative-hypnotic, antistress, anxiolytic, and cognitive effects. J Ginseng Res 2017;41:201-8. https://doi.org/10.1016/j.jgr.2016.03.005
- Kraeuter AK, Guest PC, Sarnyai Z. The elevated plus maze test for measuring anxiety-like behavior in rodents. Methods Mol Biol 2019;1916:69-74. https://doi.org/10.1007/978-1-4939-8994-2_4
- Kedia S, Chattarji S. Marble burying as a test of the delayed anxiogenic effects of acute immobilisation stress in mice. J Neurosci Methods 2014;233:150-4. https://doi.org/10.1016/j.jneumeth.2014.06.012
- Lee B, Sur B, Cho SG, Yeom M, Shim I, Lee H, Hahm DH. Ginsenoside Rb1 rescues anxiety-like responses in a rat model of post-traumatic stress disorder. J Nat Med 2016;70:133-44. https://doi.org/10.1007/s11418-015-0943-3
- Bui BP, Oh Y, Lee H, Cho J. Inhibition of inflammatory mediators and cell migration by 1,2,3,4-tetrahydroquinoline derivatives in LPS-stimulated BV2 microglial cells via suppression of NF-kB and JNK pathway. Int Immunopharmacol 2020;80:106231. https://doi.org/10.1016/j.intimp.2020.106231
- Jeong Y, Bae HJ, Park K, Bae HJ, Yang X, Cho YJ, Jung SY, Jang DS, Ryu JH. 4- Methoxycinnamic acid attenuates schizophrenia-like behaviors induced by MK-801 in mice. J Ethnopharmacol 2022;285:114864. https://doi.org/10.1016/j.jep.2021.114864
- Pellow S, File SE. Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze: a novel test of anxiety in the rat. Pharmacol Biochem Behav 1986;24:525-9. https://doi.org/10.1016/0091-3057(86)90552-6
- Domingues M, Casaril AM, Birmann PT, Bampi SR, Lourenco D, Vieira BM, Dapper LH, Lenard~ ao EJ, Sonego M, Collares T, et al. Effects of a selanylimidazopyridine on the acute restraint stress-induced depressive- and anxietylike behaviors and biological changes in mice. Behav Brain Res 2019;366: 96-107. https://doi.org/10.1016/j.bbr.2019.03.021
- Miao Z, Wang Y, Sun Z. The relationships between stress, mental disorders, and epigenetic regulation of BDNF. Int J Mol Sci 2020:21.
- Bao HY, Zhang J, Yeo SJ, Myung C-S, Kim HM, Kim JM, Park JH, Cho J, Kang JS. Memory enhancing and neuroprotective effects of selected ginsenosides. Arch Pharm Res 2005;28:335. https://doi.org/10.1007/BF02977802
- Kim HJ, Kim P, Shin CY. A comprehensive review of the therapeutic and pharmacological effects of ginseng and ginsenosides in central nervous system. J Ginseng Res 2013;37:8-29. https://doi.org/10.5142/jgr.2013.37.8
- He B, Chen P, Yang J, Yun Y, Zhang X, Yang R, Shen Z. Neuroprotective effect of 20(R)-ginsenoside Rg3 against transient focal cerebral ischemia in rats. Neurosci Lett 2012;526:106-11. https://doi.org/10.1016/j.neulet.2012.08.022
- Lee KH, Bahk WM, Lee SJ, Pae CU. Effectiveness and tolerability of Korean Red Ginseng augmentation in major depressive disorder patients with difficult-totreat in routine practice. Clin Psychopharmacol Neurosci 2020;18:621-6. https://doi.org/10.9758/cpn.2020.18.4.621
- Jin Y, Cui R, Zhao L, Fan J, Li B. Mechanisms of Panax ginseng action as an antidepressant. Cell Prolif 2019;52:e12696. https://doi.org/10.1111/cpr.12696
- Lee S, Rhee DK. Effects of ginseng on stress-related depression, anxiety, and the hypothalamic-pituitary-adrenal axis. J Ginseng Res 2017;41:589-94. https://doi.org/10.1016/j.jgr.2017.01.010
- Lee B, Sur B, Cho SG, Yeom M, Shim I, Lee H, Hahm DH. Ginsenoside Rb1 rescues anxiety-like responses in a rat model of post-traumatic stress disorder. J Nat Med 2016;70:133-44. https://doi.org/10.1007/s11418-015-0943-3
- Cha HY, Park JH, Hong JT, Yoo HS, Song S, Hwang BY, Eun JS, Oh KW. Anxiolytic-like effects of ginsenosides on the elevated plus-maze model in mice. Biol Pharm Bull 2005;28:1621-5. https://doi.org/10.1248/bpb.28.1621
- Carr MN, Bekku N, Yoshimura H. Identification of anxiolytic ingredients in ginseng root using the elevated plus-maze test in mice. Eur J Pharmacol 2006;531:160-5. https://doi.org/10.1016/j.ejphar.2005.12.014
- Xie X, Yang H, An JJ, Houtz J, Tan JW, Xu H, Liao GY, Xu ZX, Xu B. Activation of anxiogenic circuits instigates resistance to diet-induced obesity via increased energy expenditure. Cell Metab 2019;29:917-31. https://doi.org/10.1016/j.cmet.2018.12.018
- Seibenhener ML, Wooten MC. Use of the open field maze to measure locomotor and anxiety-like behavior in mice. J Vis Exp 2015:52434.
- Thibaut F. Anxiety disorders: a review of current literature. Dialogues Clin Neurosci 2017;19:87-8. https://doi.org/10.31887/DCNS.2017.19.2/fthibaut
- Xiang M, Jiang Y, Hu Z, Yang Y, Du X, Botchway BO, Fang M. Serotonin receptors 2A and 1A modulate anxiety-like behavior in post-traumatic stress disordered mice. Am J Transl Res 2019;11:2288-303.
- Celada P, Puig MV, Casanovas JM, Guillazo G, Artigas F. Control of dorsal raphe serotonergic neurons by the medial prefrontal cortex: involvement of serotonin-1A, GABAA, and glutamate receptors. J Neurosci 2001;21:9917-29. https://doi.org/10.1523/JNEUROSCI.21-24-09917.2001
- Llado-Pelfort L, Santana N, Ghisi V, Artigas F, Celada P. 5-HT1A receptor ag- onists enhance pyramidal cell firing in prefrontal cortex through a preferential action on GABA interneurons. Cereb Cortex 2012;22:1487-97. https://doi.org/10.1093/cercor/bhr220
- Brambilla P, Perez J, Barale F, Schettini G, Soares JC. GABAergic dysfunction in mood disorders. Mol Psychiatry 2003;8:721-37. 15. https://doi.org/10.1038/sj.mp.4001362
- Stein L, Belluzzi JD, Wise CD. Benzodiazepines: behavioral and neurochemical mechanisms. Am J Psychiatry 1977;134:665-9. https://doi.org/10.1176/ajp.134.6.665
- Zaletel I, Filipovic D, Puskas N. Hippocampal BDNF in physiological conditions and social isolation. Rev Neurosci 2017;28:675-92. https://doi.org/10.1515/revneuro-2016-0072
- Shimizu E, Hashimoto K, Okamura N, Koike K, Komatsu N, Kumakiri C, Nakazato M, Watanabe H, Shinoda N, Okada S, et al. Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants. Biol Psychiatry 2003;54:70-5. https://doi.org/10.1016/S0006-3223(03)00181-1
- Zhu G, Sun X, Yang Y, Du Y, Lin Y, Xiang J, Zhou N. Reduction of BDNF results in GABAergic neuroplasticity dysfunction and contributes to late-life anxiety disorder. Behav Neurosci 2019;133:212-24. https://doi.org/10.1037/bne0000301
- Martinowich K, Lu B. Interaction between BDNF and serotonin: role in mood disorders. Neuropsychopharmacology 2008;33:73-83. https://doi.org/10.1038/sj.npp.1301571
- Madhav TR, Pei Q, Zetterstrom TS. Serotonergic cells of the rat raphe nuclei express mRNA of tyrosine kinase B (trkB), the high-affinity receptor for brain derived neurotrophic factor (BDNF). Brain Res Mol Brain Res 2001;93:56-63. https://doi.org/10.1016/S0169-328X(01)00183-8
- Nibuya M, Nestler EJ, Duman RS. Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus. J Neurosci 1996;16:2365-72. https://doi.org/10.1523/JNEUROSCI.16-07-02365.1996
- Anthony TE, Dee N, Bernard A, Lerchner W, Heintz N, Anderson DJ. Control of stress-induced persistent anxiety by an extra-amygdala septohypothalamic circuit. Cell 2014;156:522-36. https://doi.org/10.1016/j.cell.2013.12.040