Clinical and Experimental Vaccine Research

The Korean Vaccine Society (대한백신학회)
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Quick drop of platelet counts in children with chronic immune thrombocytopenia after COVID-19 mRNA vaccination: case reports

  • Giuseppe Lassandro (Department Interdisciplinary of Medicine, Pediatric Unit "B. Trambusti", University of Bari "Aldo Moro") ;
  • Francesco Carriero (Department Interdisciplinary of Medicine, Pediatric Unit "B. Trambusti", University of Bari "Aldo Moro") ;
  • Valentina Palladino (Department Interdisciplinary of Medicine, Pediatric Unit "B. Trambusti", University of Bari "Aldo Moro") ;
  • Giovanni Carlo Del Vecchio (Department Interdisciplinary of Medicine, Pediatric Unit "B. Trambusti", University of Bari "Aldo Moro") ;
  • Paola Giordano (Department Interdisciplinary of Medicine, Pediatric Unit "B. Trambusti", University of Bari "Aldo Moro")
  • Received : 2022.01.02
  • Accepted : 2022.04.30
  • Published : 2022.09.30
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Abstract

Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by isolated thrombocytopenia. Many viruses and some vaccines have been identified as triggering the autoimmune process, including parvovirus, human immunodeficiency virus, Epstein-Barr virus, rubella, and measles. However, ITP in association with coronavirus disease 2019 (COVID-19) vaccination has not been reported so far. We describe the cases of two young girls affected by ITP presenting a quick reduction of platelet count after receiving Pfizer-BioNTech COVID-19 vaccine.

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References

  1. Giordano P, Lassandro G, Giona F, et al. ITP-QoL questionnaire for children with immune thrombocytopenia: Italian version validation's. Pediatr Hematol Oncol 2014;31:534-47. 
  2. Rinaldi M, Perricone C, Ortega-Hernandez OD, Perricone R, Shoenfeld Y. Immune thrombocytopaenic purpura: an autoimmune cross-link between infections and vaccines. Lupus 2014;23:554-67. 
  3. Audia S, Mahevas M, Nivet M, Ouandji S, Ciudad M, Bonnotte B. Immune thrombocytopenia: recent advances in pathogenesis and treatments. Hemasphere 2021;5:e574. 
  4. Lassandro G, Palladino V, Amoruso A, Palmieri VV, Russo G, Giordano P. Children in coronaviruses' wonderland: what clinicians need to know. Mediterr J Hematol Infect Dis 2020;12:e2020042. 
  5. Lassandro G, Palladino V, Palmieri VV, Amoruso A, Del Vecchio GC, Giordano P. COVID-19 and children with immune thrombocytopenia: emerging issues. Mediterr J Hematol Infect Dis 2020;12:e2020028. 
  6. Food and Drug Administration. Fact sheet for healthcare providers administering vaccine (vaccination providers): Emergency Use Authorization (EUA) of the Pfizer-BioN-Tech COVID-19 vaccine to prevent coronavirus disease 2019 (COVID-19). Silver Spring (MD): Food and Drug Administration; 2020. 
  7. Magdi M, Rahil A. Severe immune thrombocytopenia complicated by intracerebral haemorrhage associated with coronavirus infection: a case report and literature review. Eur J Case Rep Intern Med 2019;6:001155. 
  8. Lee EJ, Cines DB, Gernsheimer T, et al. Thrombocytopenia following Pfizer and Moderna SARS-CoV-2 vaccination. Am J Hematol 2021;96:534-7. 
  9. Giordano P, Lassandro G, Barone A, et al. Use of eltrombopag in children with chronic immune thrombocytopenia (ITP): a real life retrospective multicenter experience of the Italian Association of Pediatric Hematology and Oncology (AIEOP). Front Med (Lausanne) 2020;7:66. 
  10. Giordano P, Cascioli S, Lassandro G, et al. B-cell hyperfunction in children with immune thrombocytopenic purpura persists after splenectomy. Pediatr Res 2016;79:262-70. 
  11. McCrae K. Immune thrombocytopenia: no longer 'idiopathic'. Cleve Clin J Med 2011;78:358-73. 
  12. Bhattacharjee S, Banerjee M. Immune thrombocytopenia secondary to COVID-19: a systematic review. SN Compr Clin Med 2020;2:2048-58. 
  13. Perricone C, Ceccarelli F, Nesher G, et al. Immune thrombocytopenic purpura (ITP) associated with vaccinations: a review of reported cases. Immunol Res 2014;60:226-35. 
  14. Saudagar V, Patil S, Goh S, Pothiawala S. Vigilance regarding immune thrombocytopenic purpura after COVID-19 vaccine. Ir J Med Sci 2022;191:919-20. 
  15. Giordano P, Lassandro G, di Meo NA, et al. A narrative approach to describe QoL in children with chronic ITP. Front Pediatr 2019;7:163.