Clinical and Experimental Vaccine Research

The Korean Vaccine Society (대한백신학회)
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Heterologous prime-boost with the mRNA-1273 vaccine among CoronaVac-vaccinated healthcare workers in Indonesia

  • Theresia Santi (Siloam Hospitals Lippo Cikarang) ;
  • Veli Sungono (Faculty of Medicine, Universitas Pelita Harapan) ;
  • Lina Kamarga (Siloam Hospitals Lippo Cikarang) ;
  • Baringin De Samakto (Siloam Hospitals Lippo Cikarang) ;
  • Ferry Hidayat (Siloam Hospitals Lippo Cikarang) ;
  • Feronica Kusuma Hidayat (Siloam Hospitals Lippo Cikarang) ;
  • Magy Satolom (Siloam Hospitals Lippo Cikarang) ;
  • Anita Permana (Siloam Hospitals Lippo Cikarang) ;
  • Irawan Yusuf (Faculty of Medicine, Hasanuddin University) ;
  • Ivet Marita Suriapranata (Faculty of Medicine, Universitas Pelita Harapan) ;
  • Juandy Jo (Mochtar Riady Institute for Nanotechnology)
  • Received : 2021.11.23
  • Accepted : 2022.04.29
  • Published : 2022.05.31
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Abstract

Purpose: This study was performed to investigate humoral immune response and adverse events upon the heterologous prime-boost with a single dose of the mRNA-1273 vaccine among fully CoronaVac-vaccinated, infection-naïve healthcare workers in Indonesia. Materials and Methods: One hundred twenty-five eligible healthcare workers were recruited from one hospital for this prospective cohort study. Blood collection was conducted twice, i.e., on 7 days before and 28 days after the booster vaccination. The titer of anti-SARS-CoV-2 receptor-binding domain (RBD) antibodies was quantified accordingly. The post-vaccination adverse event was recorded for both CoronaVac and mRNA-1273 vaccinations. Any breakthrough infection was monitored during the follow-up period. Wilcoxon matched-pairs signed rank test was used to test differences between groups. Results: A significant increase was observed in the titer of anti-SARS-CoV-2 RBD antibodies upon receiving the mRNA-1273 booster (geometric mean titers of 65.57 and 47,445 U/mL in pre-and post-booster, respectively), supporting the argument to use heterologous prime-boost vaccination to improve the protection against COVID-19 in a high-risk population. The mRNA1273 vaccine, however, caused a higher frequency of adverse events than the CoronaVac vaccine. Nonetheless, the adverse events were considered minor medical events and temporary as all subjects were not hospitalized and fully recovered. Of note, no breakthrough infection was observed during the follow-up to 12 weeks post-booster. Conclusion: The heterologous prime-boost vaccination of healthcare workers with a single dose of the mRNA-1273 vaccine generated a significant elevation in humoral immune response towards RBD of SARS-CoV-2 and was associated with a higher frequency, but minor and transient, adverse events.

Keywords

References

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