Clinical Psychopharmacology and Neuroscience

Korean College of Neuropsychopharmacology (대한정신약물학회)
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Neuromolecular Etiology of Bipolar Disorder: Possible Therapeutic Targets of Mood Stabilizers

  • Jung Goo Lee (Department of Psychiatry, Haeundae Paik Hospital, Inje University College of Medicine) ;
  • Young Sup Woo (Department of Psychiatry, College of Medicine, The Catholic University of Korea) ;
  • Sung Woo Park (Paik Institute for Clinical Research, Inje University) ;
  • Dae-Hyun Seog (Department of Biochemistry, Inje University College of Medicine) ;
  • Mi Kyoung Seo (Paik Institute for Clinical Research, Inje University) ;
  • Won-Myong Bahk (Department of Psychiatry, College of Medicine, The Catholic University of Korea)
  • Received : 2021.08.25
  • Accepted : 2021.08.30
  • Published : 20220000
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Abstract

Bipolar disorder is a mental illness that causes extreme mood swings and has a chronic course. However, the mechanism by which mood episodes with completely opposite characteristics appear repeatedly, or a mixture of symptoms appears, in patients with bipolar disorder remains unknown. Therefore, mood stabilizers are indicated only for single mood episodes, such as manic episodes and depressive episodes, and no true mood-stabilizing drugs effective for treating both manic and depressive episodes currently exist. Therefore, in this review, therapeutic targets that facilitate the development of mood stabilizers were examined by reviewing the current understanding of the neuromolecular etiology of bipolar disorder.

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Acknowledgement

This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (NRF-2021R1A2C1003591 to J.G. Lee).