Anatomy and Cell Biology

  • 제55권1호
  • /
  • Pages.20-27
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  • 2022
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  • 2093-3665(pISSN)
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  • 2093-3673(eISSN)
대한해부학회 (Korean Association of Anatomists)
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Blood-retina barrier dysfunction in experimental autoimmune uveitis: the pathogenesis and therapeutic targets

  • Jeongtae Kim (Department of Anatomy, Kosin University College of Medicine) ;
  • Jiyoon Chun (Department of Veterinary Anatomy, College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University) ;
  • Meejung Ahn (Department of Animal Science, College of Life Science, Sangji University) ;
  • Kyungsook Jung (Functional Biomaterials Research Center, Korea Research Institute of Bioscience and Biotechnology) ;
  • Changjong Moon (Department of Veterinary Anatomy, College of Veterinary Medicine and BK21 Plus Project Team, Chonnam National University) ;
  • Taekyun Shin (Department of Veterinary Anatomy, College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University)
  • 투고 : 2021.11.12
  • 심사 : 2022.01.06
  • 발행 : 2022.03.31
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초록

Experimental autoimmune uveitis (EAU), an animal model of human uveitis, is characterized by infiltration of autoimmune T cells in the uvea as well as in the retina of susceptible animals. EAU is induced by the immunization of uveitogenic antigens, including either retinal soluble-antigen or interphotoreceptor retinoid-binding proteins, in Lewis rats. The pathogenesis of EAU in rats involves the proliferation of autoimmune T cells in peripheral lymphoid tissues and breakdown of the blood-retinal barrier, primarily in the uvea and retina, finally inducing visual dysfunction. In this review, we describe recent EAU studies to facilitate the design of a therapeutic strategy through the interruption of uveitogenic factors during the course of EAU, which will be helpful for controlling human uveitis.

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과제정보

This research was supported by the National Research Foundation of Korea (Grant number: NRF- 2019R1A2C1087753) and a grant from Kosin University College of Medicine (2021).

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