Molecules and Cells

Korean Society for Molecular and Cellular Biology (한국분자세포생물학회)
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The Single-Cell Revelation of Thermogenic Adipose Tissue

  • Qi, Yue (School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong) ;
  • Hui, Xiaoyan Hannah (School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong)
  • Received : 2022.06.03
  • Accepted : 2022.07.11
  • Published : 2022.10.31
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Abstract

The past two decades have witnessed an upsurge in the appreciation of adipose tissue (AT) as an immunometabolic hub harbouring heterogeneous cell populations that collectively fine-tune systemic metabolic homeostasis. Technological advancements, especially single-cell transcriptomics, have offered an unprecedented opportunity for dissecting the sophisticated cellular networks and compositional dynamics underpinning AT remodelling. The "re-discovery" of functional brown adipose tissue dissipating heat energy in human adults has aroused tremendous interest in exploiting the mechanisms underpinning the engagement of AT thermogenesis for combating human obesity. In this review, we aim to summarise and evaluate the use of single-cell transcriptomics that contribute to a better appreciation of the cellular plasticity and intercellular crosstalk in thermogenic AT.

Keywords

Acknowledgement

This work is supported by the National Natural Science Foundation of China (NSFC) - Excellent Young Scientists Fund (Hong Kong and Macau) (81922079) and General Research Fund (17121520) (to X.H.H.).

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