Acknowledgement
This research was supported by National R&D Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (NRF2020R1A2B5B02002442) and BK21 Four Future Veterinary Medicine Leading Education & Research Center.
References
- Ahn, S.H., Ryu, S.W., Choi, H., You, S., Park, J., and Choi, C. (2022). Manufacturing therapeutic exosomes: from bench to industry. Mol. Cells 45, 284-290. https://doi.org/10.14348/molcells.2022.2033
- Castano, C., Kalko, S., Novials, A., and Parrizas, M. (2018). Obesity-associated exosomal miRNAs modulate glucose and lipid metabolism in mice. Proc. Natl. Acad. Sci. U. S. A. 115, 12158-12163. https://doi.org/10.1073/pnas.1808855115
- Choi, E.J., Jeon, C.H., Park, D.H., and Kwon, T.H. (2020). Allithiamine exerts therapeutic effects on sepsis by modulating metabolic flux during dendritic cell activation. Mol. Cells 43, 964-973. https://doi.org/10.14348/molcells.2020.0198
- Jafari, N., Llevenes, P., and Denis, G.V. (2022). Exosomes as novel biomarkers in metabolic disease and obesity-related cancers. Nat. Rev. Endocrinol. 18, 327-328. https://doi.org/10.1038/s41574-022-00666-7
- Kita, S., Maeda, N., and Shimomura, I. (2019). Interorgan communication by exosomes, adipose tissue, and adiponectin in metabolic syndrome. J. Clin. Invest. 129, 4041-4049. https://doi.org/10.1172/JCI129193
- Kumar, A., Ren, Y., Sundaram, K., Mu, J., Sriwastva, M.K., Dryden, G.W., Lei, C., Zhang, L., Yan, J., Zhang, X., et al. (2021a). miR-375 prevents high-fat diet-induced insulin resistance and obesity by targeting the aryl hydrocarbon receptor and bacterial tryptophanase (tnaA) gene. Theranostics 11, 4061-4077. https://doi.org/10.7150/thno.52558
- Kumar, A., Sundaram, K., Mu, J., Dryden, G.W., Sriwastva, M.K., Lei, C., Zhang, L., Qiu, X., Xu, F., Yan, J., et al. (2021b). High-fat diet-induced upregulation of exosomal phosphatidylcholine contributes to insulin resistance. Nat. Commun. 12, 213. https://doi.org/10.1038/s41467-020-20500-w
- Mei, R., Qin, W., Zheng, Y., Wan, Z., and Liu, L. (2022). Role of adipose tissue derived exosomes in metabolic disease. Front. Endocrinol. (Lausanne) 13, 873865. https://doi.org/10.3389/fendo.2022.873865
- Roh, E., Kwak, S.H., Jung, H.S., Cho, Y.M., Pak, Y.K., Park, K.S., Kim, S.Y., and Lee, H.K. (2015). Serum aryl hydrocarbon receptor ligand activity is associated with insulin resistance and resulting type 2 diabetes. Acta Diabetol. 52, 489-495. https://doi.org/10.1007/s00592-014-0674-z
- Van den Bossche, J. (2020). Fatty exosomes hamper antitumor immunity. Sci. Transl. Med. 12, eabf4685. https://doi.org/10.1126/scitranslmed.abf4685
- Wu, H. and Ballantyne, C.M. (2020). Metabolic inflammation and insulin resistance in obesity. Circ. Res. 126, 1549-1564. https://doi.org/10.1161/CIRCRESAHA.119.315896
- Yin, X., Zeng, W., Wu, B., Wang, L., Wang, Z., Tian, H., Wang, L., Jiang, Y., Clay, R., Wei, X., et al. (2020). PPARα inhibition overcomes tumor-derived exosomal lipid-induced dendritic cell dysfunction. Cell Rep. 33, 108278. https://doi.org/10.1016/j.celrep.2020.108278
- Zhang, J., Tan, J., Wang, M., Wang, Y., Dong, M., Ma, X., Sun, B., Liu, S., Zhao, Z., Chen, L., et al. (2021). Lipid-induced DRAM recruits STOM to lysosomes and induces LMP to promote exosome release from hepatocytes in NAFLD. Sci. Adv. 7, eabh1541. https://doi.org/10.1126/sciadv.abh1541