Clinical Nutrition Research

  • 제11권2호
  • /
  • Pages.120-132
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  • 2022
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  • 2287-3732(pISSN)
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  • 2287-3740(eISSN)
한국임상영양학회 (The Korean Society of Clinical Nutrition)
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The Effect of Walnut (Juglans regia) Leaf Extract on Glycemic Control and Lipid Profile in Patients With Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

  • Atieh Mirzababaei (Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences) ;
  • Mojtaba Daneshvar (Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences) ;
  • Faezeh Abaj (Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences) ;
  • Elnaz Daneshzad (Non-Communicable Diseases Research Center, Alborz University of Medical Sciences) ;
  • Dorsa Hosseininasab (Department of Nutrition, Science and Research Branch, Islamic Azad University) ;
  • Cain C. T. Clark (Centre for Intelligent Healthcare, Coventry University) ;
  • Khadijeh Mirzaei (Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences)
  • 투고 : 2022.02.12
  • 심사 : 2022.04.14
  • 발행 : 2022.04.30
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초록

Numerous clinical trials have examined the beneficial effects of Juglans regia leaf extract (JRLE) in patients with type 2 diabetes mellitus (T2DM); however, the results of these studies are inconsistent. Therefore, we conducted the current systematic review and meta-analysis to evaluate the effect of JRLE on glycemic control and lipid profile in T2DM patients. We searched online databases including PubMed, Scopus, EMBASE, and Web of Science for randomized controlled clinical trials that examined the effect of JRLE on glycemic and lipid indices in T2DM patients. Data were pooled using both fixed and random-effect models and weighted mean difference (WMD) was considered as the overall effect size. Of the total records, 4 eligible studies, with a total sample size of 195 subjects, were included. The meta-analysis revealed that JRLE supplementation significantly reduces fasting blood glucose (WMD, -18.04; 95% confidence interval [CI], -32.88 mg/dL, -3.21 mg/dL; p = 0.017) and significantly increases fasting insulin level (WMD, 1.93; 95% CI, 0.40 U/L, 3.45 U/L; p = 0.014). Although the overall effect of JRLE supplementation on hemoglobin A1c was not significant, a significant reduction was seen in studies with an intervention duration of > 8 weeks (WMD, -0.64; 95% CI, -1.16%, -0.11%; p = 0.018). Moreover, we also found no significant change in lipid parameters. Our findings revealed a beneficial effect of JRLE supplementation on glycemic indices in T2DM patients, but no significant improvement was found for lipid profile parameters.

키워드

과제정보

This study was supported by the Student's Scientific Research Center, Tehran, Iran.

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