The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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Effects of Yigong-san for the Treatment of Anorexia in Children: A Systematic Review and Meta-Analysis

소아 식욕부진에 대한 이공산(異功散) 치료의 효과 : 체계적 문헌고찰 및 메타분석

  • Lee, Bo-ram (KM Science Research Division, Korea Institute of Oriental Medicine) ;
  • Ha, Da-jung (Dept. of Internal Medicine, Dong-eui University College of Korean Medicine) ;
  • Huh, Tae-young (Dept. of Internal Medicine, Dong-eui University College of Korean Medicine) ;
  • Park, Sang-eun (Dept. of Internal Medicine, Dong-eui University College of Korean Medicine) ;
  • Lee, Sun-haeng (Dept. of Korean Pediatrics, College of Korean Medicine, Kyung Hee University) ;
  • Chang, Gyu-tae (Dept. of Korean Pediatrics, College of Korean Medicine, Kyung Hee University)
  • 이보람 (한국한의학연구원 한의과학연구부) ;
  • 하다정 (동의대학교 한의과대학 내과학교실) ;
  • 허태영 (동의대학교 한의과대학 내과학교실) ;
  • 박상은 (동의대학교 한의과대학 내과학교실) ;
  • 이선행 (경희대학교 한의과대학 소아과학교실) ;
  • 장규태 (경희대학교 한의과대학 소아과학교실)
  • Received : 2022.08.01
  • Accepted : 2022.10.04
  • Published : 2022.09.30
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Abstract

Objectives: The purpose of this study was to assess the effect of Yigong-san on anorexia in children by conducting a systematic review and meta-analysis of randomized controlled trials (RCTs). Methods: Eleven electronic databases were searched on May 30, 2022 to collect relevant studies. All studies published up to the search date were considered. RCTs reporting the effect of Yigong-san on the treatment of anorexia in children were included. The primary outcome was an improvement in clinical anorexia symptoms after treatment. In this meta-analysis, continuous and binary outcomes were assessed, and the data were presented as the mean difference and risk ratio with their 95% confidence intervals. The risk of bias was assessed using the Cochrane Collaboration's risk of bias tool. Results: A total of nine studies were included in this systematic review. The treatment group (Yigong-san only or Yigong-san plus conventional treatment) showed a statistically significant effect compared to the control group (conventional treatment only) in total effective rate (Yigong-san only: RR 1.26, 95% CI 1.17, 1.36, I2=0%; Yigong-san plus conventional treatment: RR 1.32, 95% CI 1.18, 1.47, I2=0%), clinical symptoms, some of the anthropometric outcomes, and biological markers related to appetite and growth in children with anorexia. No serious adverse events related to Yigong-san were reported. Conclusions: Yigong-san showed statistically significant effects as a treatment for anorexia in children. However, the number of studies included in the meta-analysis was insufficient, and the herbs contained in the Yigong-san used in the included studies were not standardized. Future research should focus on the implementation of methodologically robust clinical research.

Keywords

References

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