Physical Therapy Rehabilitation Science

  • 제11권3호
  • /
  • Pages.304-310
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  • 2022
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  • 2287-7576(pISSN)
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  • 2287-7584(eISSN)
물리치료재활과학회 (korean Academy of Physical Therapy Rehabilitation Science)
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The Effect of Aerobic Exercise on Brain-Derived Neurotrophic Factor (BDNF) in Individuals with Mild Cognitive Impairment: a Systematic Review and Meta-Analysis of a Randomized Controlled Trials

  • Kim, Hyun-Joong (Women's cancer center Chunghalin, Chung Yeon Rehabilitation Hospital) ;
  • Lee, DongJin (Department of Physical Therapy, Gwangju Health University) ;
  • Lee, YeonSeop (Department of Physical Therapy, Daewon University College)
  • 투고 : 2022.07.26
  • 심사 : 2022.09.09
  • 발행 : 2022.09.30
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초록

Objective: Mild cognitive impairment (MCI) is a condition in which cognitive and executive functions are reduced, and older adults with MCI are ten times more likely to develop dementia than healthy older adults. Expression of brain-derived neurotrophic factor (BDNF) through aerobic exercise is associated with increased cognitive and executive functions. in this review, randomized controlled trials (RCTs) on the effects of aerobic exercise on BDNF in individuals with mild cognitive impairment are summarized and qualitatively and quantitatively analyzed to suggest the necessity of aerobic exercise. Design: a systematic review and meta-analysis. Methods: RCTs were searched for changes in BDNF through aerobic exercise using four international databases. Quality assessment and quantitative analysis were performed using RevMan 5.4. Quantitative analysis was quantified with a standardized mean difference (SMD) and presented as a random effect model. Results: Three RCTs evaluated BDNF in 123 patients with MCI. There was a significant improvement in the experimental group that performed aerobic exercise compared to the control group. The results analyzed using the random effects model were SMD = 0.48. Conclusions: In this review, we reported the effects and mechanisms of aerobic exercise in individuals with MCI. As a result of synthesizing RCTs that performed aerobic exercise, a significant increase in BDNF was confirmed.

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과제정보

The Research has been conducted by the Research Grant of Gwangju Health University in 2022 (2022006).

참고문헌

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