DOI QR코드

DOI QR Code

Development of Korean CARcinogen EXposure: Assessment of the Exposure Intensity of Carcinogens by Industry

  • Koh, Dong-Hee (Department of Occupational and Environmental Medicine, International St. Mary's Hospital, Catholic Kwandong University) ;
  • Park, Ju-Hyun (Department of Statistics, Dongguk University) ;
  • Lee, Sang-Gil (Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency) ;
  • Kim, Hwan-Cheol (Department of Occupational and Environmental Medicine, Inha University) ;
  • Jung, Hyejung (Department of Occupational and Environmental Medicine, International St. Mary's Hospital, Catholic Kwandong University) ;
  • Kim, Inah (Department of Occupational and Environmental Medicine, College of Medicine, Hanyang University) ;
  • Choi, Sangjun (Department of Preventive Medicine, College of Medicine, The Catholic University of Korea) ;
  • Park, Donguk (Department of Environmental Health, Korea National Open University)
  • 투고 : 2022.02.15
  • 심사 : 2022.05.17
  • 발행 : 2022.09.30

초록

Background: Occupational cancer is a global health issue. The Korean CARcinogen EXposure (K-CAREX), a database of CARcinogen EXposure, was developed for the Korean labor force to estimate the number of workers exposed to carcinogens by industry. The present study aimed to estimate the intensity of exposure to carcinogens by industry, in order to supply complementary information about CARcinogen EXposure intensity to the K-CAREX. Methods: We used nationwide workplace monitoring data from 2014 to 2016 and selected target carcinogens based on the K-CAREX list. We computed the 95th percentile levels of measurements for each industry by carcinogens. Based on the 95th percentile level relative to the occupational exposure limit, we classified the CARcinogen EXposure intensity into five exposure ratings (1-5) for each industry. Results: The exposure ratings were estimated for 21 carcinogenic agents in each of the 228 minor industry groups. For example, 3,058 samples were measured for benzene in the manufacturing industry of basic chemicals. This industry was assigned a benzene exposure rating of 3. Conclusions: We evaluated the CARcinogen EXposure ratings across industries in Korean workers. The results will provide information on the exposure intensity to carcinogens for integration into the K-CAREX. Furthermore, it will aid in prioritizing control efforts and identifying industries of concern.

키워드

과제정보

This study was supported by the Basic Science Research Program through the National Research Foundation of Korea, funded by the Ministry of Education (grant number 2017R1D1A1B04032379). This study was also supported by the Occupational Safety and Health Research Institute grant (2021-OSHRI-795), funded by the Korea Occupational Safety and Health Agency.

참고문헌

  1. Hong S, Won Y-J, Lee JJ, Jung K-W, Kong H-J, Im J-S, et al. Cancer statistics in Korea: incidence, mortality, survival, and prevalence in 2018. Cancer Res Treat 2021;53:301-15. https://doi.org/10.4143/crt.2021.291
  2. Brown KF, Rumgay H, Dunlop C, Ryan M, Quartly F, Cox A, et al. The fraction of cancer attributable to modifiable risk factors in England, Wales, Scotland, Northern Ireland, and the United Kingdom in 2015. Br J Cancer 2018;118:1130-41. https://doi.org/10.1038/s41416-018-0029-6
  3. Doll R, Peto R. The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. J Natl Cancer Inst 1981;66:1191-308.
  4. Geiser K. Chemicals without harm-policies for a sustainable world. MIT Press; 2015.
  5. Lee T, Gany F. Cooking oil fumes and lung cancer: a review of the literature in the context of the U.S. population. J Immigr Minor Health 2013;15:646-52. https://doi.org/10.1007/s10903-012-9651-1
  6. Loomis D, Guha N, Hall AL, Straif K. Identifying occupational carcinogens: an update from the IARC monographs. Occup Environ Med 2018;75:593-603. https://doi.org/10.1136/oemed-2017-104944
  7. Blanco-Romero LE, Vega LE, Lozano-Chavarria LM, Partanen TJ. CAREX Nicaragua and Panama: worker exposures to carcinogenic substances and pesticides. Int J Occup Environ Health 2011;17:251-7. https://doi.org/10.1179/oeh.2011.17.3.251
  8. Kauppinen T, Pajarskiene B, Podniece Z, Rjazanov V, Smerhovsky Z, Veidebaum T, et al. Occupational exposure to carcinogens in Estonia, Latvia, Lithuania and the Czech Republic in 1997. Scand J Work Environ Health 2001;27:343-5. https://doi.org/10.5271/sjweh.623
  9. Mirabelli D, Kauppinen T. Occupational exposures to carcinogens in Italy: an update of CAREX database. Int J Occup Environ Health 2005;11:53-63. https://doi.org/10.1179/oeh.2005.11.1.53
  10. Partanen T, Chaves J, Wesseling C, Chaverri F, Monge P, Ruepert C, et al. Workplace carcinogen and pesticide exposures in Costa Rica. Int J Occup Environ Health 2003;9:104-11. https://doi.org/10.1179/oeh.2003.9.2.104
  11. Peters CE, Ge CB, Hall AL, Davies HW, Demers PA. CAREX Canada: an enhanced model for assessing occupational carcinogen exposure. Occup Environ Med 2015;72:64-71. https://doi.org/10.1136/oemed-2014-102286
  12. Kauppinen T, Toikkanen J, Pedersen D, Young R, Ahrens W, Boffetta P, et al. Occupational exposure to carcinogens in the European Union. Occup Environ Med 2000;57:10-8. https://doi.org/10.1136/oem.57.1.10
  13. Koh DH, Park JH, Lee SG, Kim HC, Choi S, Jung H, et al. Development of Korean CARcinogen EXposure: an initiative of the occupational carcinogen surveillance system in Korea. Ann Work Expo Health 2021;65:528-38. https://doi.org/10.1093/annweh/wxaa135
  14. Park H, Ha E, Kim J, Jung H, Paek D. Occupational health services for smallscale enterprises in Korea. Ind Health 2002;40:1-6. https://doi.org/10.2486/indhealth.40.1
  15. Koh DH, Park JH, Lee SG, Kim HC, Choi S, Jung H, et al. Combining lead exposure measurements and experts' judgment through a Bayesian framework. Ann Work Expo Health 2017;61:1054-75. https://doi.org/10.1093/annweh/wxx072
  16. Koh DH, Park JH, Lee SG, Kim HC, Choi S, Jung H, et al. Estimation of lead exposure prevalence in Korean population through combining multiple experts' judgment based on Objective data sources. Ann Work Expo Health 2018;62:210-20. https://doi.org/10.1093/annweh/wxx106
  17. Baan R, Grosse Y, Straif K, Secretan B, El Ghissassi F, Bouvard V, et al. A review of human carcinogens - part F: chemical agents and related occupations. Lancet Oncol 2009;10:1143-4. https://doi.org/10.1016/S1470-2045(09)70358-4
  18. Birkett N, Al-Zoughool M, Bird M, Baan RA, Zielinski J, Krewski D. Overview of biological mechanisms of human carcinogens. J Toxicol Environ Health B 2019;22:288-359. https://doi.org/10.1080/10937404.2019.1643539
  19. Kim S, Yoon C, Ham S, Park J, Kwon O, Park D, et al. Chemical use in the semiconductor manufacturing industry. Int J Occup Environ Health 2018;24:109-18. https://doi.org/10.1080/10773525.2018.1519957
  20. Paik NW, Levine SP, Schork A. Development and application of a quality control program for industrial hygiene laboratories in Korea. Appl Occup Environ Hyg 1997;12:46-53. https://doi.org/10.1080/1047322X.1997.10389455
  21. Hornung RW, Reed LD. Estimation of average concentration in the presence of nondetectable values. Appl Occup Environ Hyg 1990;5:46-51. https://doi.org/10.1080/1047322X.1990.10389587
  22. Koh DH, Park JH, Lee SG, Kim HC, Jung H, Kim I, et al. Estimation of lead exposure intensity by industry using nationwide exposure databases in Korea. Saf Health Work 2021;12:439-44. https://doi.org/10.1016/j.shaw.2021.07.008
  23. Jahn SD, Bullock W, Ignacio JS. A Strategy for assessing and managing occupational exposures. 4th ed. AIHA.; 2015.
  24. Baker BA, Cassano VA, Murray C. Arsenic exposure, assessment, toxicity, diagnosis, and management: guidance for occupational and environmental physicians. J Occup Environ Med 2018;60:e634-9. https://doi.org/10.1097/JOM.0000000000001485
  25. Kang D, Jung S, Kim YJ, Kim J, Choi S, Kim SY, et al. Reconstruction of the Korean asbestos job exposure matrix. Saf Health Work 2021;12:74-95. https://doi.org/10.1016/j.shaw.2020.09.005
  26. Finkelstein MM. Asbestos-associated cancers in the Ontario refinery and petrochemical sector. Am J Ind Med 1996;30:610-5. https://doi.org/10.1002/(SICI)1097-0274(199611)30:5<610::AID-AJIM9>3.0.CO;2-W
  27. Koh D-H, Chung E-K, Jang J-K, Lee H-E, Ryu H-W, Yoo K-M, et al. Cancer incidence and mortality among temporary maintenance workers in a refinery/petrochemical complex in Korea. Int J Occup Environ Health 2014;20:141-5. https://doi.org/10.1179/2049396714Y.0000000059
  28. Kreiss K, Day GA, Schuler CR. Beryllium: a modern industrial hazard. Annu Rev Public Health 2007;28:259-77. https://doi.org/10.1146/annurev.publhealth.28.021406.144011
  29. Chung EK, Jang JK, Koh DH. A comparison of benzene exposures in maintenance and regular works at Korean petrochemical plants. J Chem Health Saf 2017;24:21-6. https://doi.org/10.1016/j.jchas.2016.09.006
  30. Koh D-H, Lee M-Y, Chung E-K, Jang J-K, Park D-U. Comparison of personal air benzene and urine t,t-muconic acid as a benzene exposure surrogate during turnaround maintenance in petrochemical plants. Ind Health 2018;56:346-55. https://doi.org/10.2486/indhealth.2017-0225
  31. Scarselli A, Corfiati M, Di Marzio D, Iavicoli S. Appraisal of levels and patterns of occupational exposure to 1,3-butadiene. Scand J Work Environ Health 2017;43:494-503. https://doi.org/10.5271/sjweh.3644
  32. Kauppinen T, Uuksulainen S, Saalo A, Makinen I, Pukkala E. Use of the Finnish information system on occupational exposure (FINJEM) in epidemiologic, surveillance, and other applications. Ann Occup Hyg 2014;58:380-96.
  33. Burdorf A. Commentary: variability in workplace exposures and the design of efficient measurement and control strategies. Ann Occup Hyg 2003;47:95-9.
  34. Cherrie JW. Reducing occupational exposure to chemical carcinogens. Occup Med 2009;59:96-100. https://doi.org/10.1093/occmed/kqn172
  35. Jeong JY, Choi S, Kho YL, Kim PG. Extensive changes to occupational exposure limits in Korea. Regul Toxicol Pharmacol 2010;58:345-8. https://doi.org/10.1016/j.yrtph.2010.08.006