Toxicological Research

  • 제38권4호
  • /
  • Pages.459-467
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  • 2022
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  • 1976-8257(pISSN)
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  • 2234-2753(eISSN)
한국독성학회 (Korean Society of Toxicology & Korea Environmental Mutagen Society)
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Evaluation of genotoxicity of SUNACTIVE Zn-P240 in vitro and in vivo

  • Lim, Jeong-Hyun (National Institute of Agricultural Science) ;
  • Lee, Jong-Yun (Health Care Institute, Korea Testing and Research Institute) ;
  • Kim, Woong-Il (College of Veterinary Medicine, Chonnam National University) ;
  • Pak, So-Won (College of Veterinary Medicine, Chonnam National University) ;
  • Lee, Se-Jin (College of Veterinary Medicine, Chonnam National University) ;
  • Shin, In-Sik (College of Veterinary Medicine, Chonnam National University) ;
  • Kim, Jong-Choon (College of Veterinary Medicine, Chonnam National University)
  • 투고 : 2021.12.01
  • 심사 : 2022.03.03
  • 발행 : 2022.10.15
⟨ 이전 논문 다음 논문 ⟩

초록

We evaluated the potential genotoxic effects of the nutrient supplement SUNACTIVE Zn-P240 in vitro and in vivo. Genotoxicity tests were performed at the Korea Testing and Research Institute, a GLP certification institution. A bacterial reverse mutation test was performed using the pre-incubation method, while the in vitro chromosome aberration test was performed using a cultured Chinese hamster lung cell line in the presence or absence of metabolic activation. The in vivo micronucleus test was performed using ICR mice. The bacterial reverse mutation test revealed that SUNACTIVE Zn-P240 did not induce genetic mutations at the tested doses in Salmonella typhimurium (TA98, TA100, TA1535, and TA1537) and Escherichia coli (WP2uvrA) tester strains. Meanwhile, the results of the in vitro chromosomal aberration and in vivo micronucleus tests revealed that SUNACTIVE Zn-P240 did not induce chromosomal aberrations. These results suggest that SUNACTIVE Zn-P240 did not exhibit mutagenic or clastogenic properties in vitro and in vivo.

키워드

과제정보

This study was financially supported by Chonnam National University (Grant number: 2020-1891). This work was also supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (NRF- 2021R1A2C2011673).

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