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Korean Society for Biochemistry and Molecular Biology (생화학분자생물학회)
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Mass spectrometry-based approaches to explore metabolism regulating ferroptosis

  • Nguyen, Chi Thi Ngoc (College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University) ;
  • Kim, Seon Min (College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University) ;
  • Kang, Yun Pyo (College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University)
  • Received : 2022.06.23
  • Accepted : 2022.08.08
  • Published : 2022.09.30
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Abstract

Ferroptosis is a type of programmed cell death distinct from apoptosis or necroptosis. Ferroptosis is well characterized by an iron-dependent accumulation of lipid peroxides and disruption of cellular membrane integrity. Many metabolic alterations can prevent or accelerate ferroptosis induction. Recent advances in analytical techniques of mass spectrometry have allowed high-throughput analysis of metabolites known to be critical for understanding ferroptosis regulatory metabolism. In this review, we introduce mass spectrometry-based analytical methods contributing to recent discovery of various metabolic pathways regulating ferroptosis, focusing on cysteine metabolism, antioxidant metabolism, and poly-unsaturated fatty acid metabolism.

Keywords

Acknowledgement

This research was supported by the New Faculty Startup Fund from Seoul National University and the National Research Foundation of Korea (NRF-2022M3A9I2017587, NRF-2022R1C1C1003619).

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