과제정보
This research was supported by National R&D Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (NRF-2021R1C1C1009595) and "Regional Innovation Strategy (RIS)" through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (MOE, 2021RIS-001).
참고문헌
- Seiwert N, Heylmann D, Hasselwander S, Fahrer J. Mechanism of colorectal carcinogenesis triggered by heme iron from red meat. Biochim Biophys Acta Rev Cancer. 2020;1873(1):188334. https://doi.org/10.1016/j.bbcan.2019.188334
- Gamage SM, Dissabandara L, Lam AK, Gopalan V. The role of heme iron molecules derived from red and processed meat in the pathogenesis of colorectal carcinoma. Crit Rev Oncol Hematol. 2018;126:121-128. https://doi.org/10.1016/j.critrevonc.2018.03.025
- Wiseman M. The second World Cancer Research Fund/American Institute for Cancer Research expert report. Food, nutrition, physical activity, and the prevention of cancer: a global perspective. Proc Nutr Soc. 2008;67(3):253-256. https://doi.org/10.1017/S002966510800712X
- Bastide NM, Pierre FH, Corpet DE. Heme iron from meat and risk of colorectal cancer: a meta-analysis and a review of the mechanisms involved. Cancer Prev Res (Phila). 2011;4(2):177-184. https://doi.org/10.1158/1940-6207.CAPR-10-0113
- Sesink AL, Termont DS, Kleibeuker JH, Van der Meer R. Red meat and colon cancer: the cytotoxic and hyperproliferative effects of dietary heme. Cancer Res 1999;59(22):5704-5709.
- Pierre F, Tache S, Petit CR, Van der Meer R, Corpet DE. Meat and cancer: haemoglobin and haemin in a low-calcium diet promote colorectal carcinogenesis at the aberrant crypt stage in rats. Carcinogenesis. 2003;24(10):1683-1690. https://doi.org/10.1093/carcin/bgg130
- Fiorito V, Chiabrando D, Petrillo S, Bertino F, Tolosano E. The multifaceted role of heme in cancer. Front Oncol. 2020;9:1540. https://doi.org/10.3389/fonc.2019.01540
- Sodring M, Oostindjer M, Egelandsdal B, Paulsen JE. Effects of hemin and nitrite on intestinal tumorigenesis in the A/J Min/+ mouse model. PLoS One. 2015;10(4):e0122880. https://doi.org/10.1371/journal.pone.0122880
- Sesink AL, Termont DS, Kleibeuker JH, Van Der Meer R. Red meat and colon cancer: dietary haem, but not fat, has cytotoxic and hyperproliferative effects on rat colonic epithelium. Carcinogenesis. 2000;21(10):1909-1915. https://doi.org/10.1093/carcin/21.10.1909
- Cheng Z, Li Y. What is responsible for the initiating chemistry of iron-mediated lipid peroxidation: an update. Chem Rev. 2007;107(3):748-766. https://doi.org/10.1021/cr040077w
- Gaschler MM, Stockwell BR. Lipid peroxidation in cell death. Biochem Biophys Res Commun. 2017;482(3):419-425. https://doi.org/10.1016/j.bbrc.2016.10.086
- Tappel A. Heme of consumed red meat can act as a catalyst of oxidative damage and could initiate colon, breast and prostate cancers, heart disease and other diseases. Med Hypotheses. 2007;68(3):562-564. https://doi.org/10.1016/j.mehy.2006.08.025
- Kim HS, Quon MJ, Kim JA. New insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenol, epigallocatechin 3-gallate. Redox Biol. 2014;2:187-195. https://doi.org/10.1016/j.redox.2013.12.022
- Eng QY, Thanikachalam PV, Ramamurthy S. Molecular understanding of epigallocatechin gallate (EGCG) in cardiovascular and metabolic diseases. J Ethnopharmacol. 2018;210:296-310. https://doi.org/10.1016/j.jep.2017.08.035
- Kuriyama S, Shimazu T, Ohmori K, Kikuchi N, Nakaya N, Nishino Y, et al. Green tea consumption and mortality due to cardiovascular disease, cancer, and all causes in Japan: the Ohsaki study. JAMA. 2006;296(10):1255-1265. https://doi.org/10.1001/jama.296.10.1255
- Meng Q, Velalar CN, Ruan R. Regulating the age-related oxidative damage, mitochondrial integrity, and antioxidative enzyme activity in Fischer 344 rats by supplementation of the antioxidant epigallocatechin-3-gallate. Rejuvenation Res. 2008;11(3):649-660. https://doi.org/10.1089/rej.2007.0645
- Na HK, Surh YJ. Modulation of Nrf2-mediated antioxidant and detoxifying enzyme induction by the green tea polyphenol EGCG. Food Chem Toxicol. 2008;46(4):1271-1278. https://doi.org/10.1016/j.fct.2007.10.006
- La X, Zhang L, Li Z, Li H, Yang Y. (-)-Epigallocatechin gallate (EGCG) enhances the sensitivity of colorectal cancer cells to 5-FU by inhibiting GRP78/NF-κB/miR-155-5p/MDR1 pathway. J Agric Food Chem. 2019;67(9):2510-2518. https://doi.org/10.1021/acs.jafc.8b06665
- Lee HJ, Jung YH, Choi GE, Ko SH, Lee SJ, Lee SH, et al. BNIP3 induction by hypoxia stimulates FASN-dependent free fatty acid production enhancing therapeutic potential of umbilical cord blood-derived human mesenchymal stem cells. Redox Biol. 2017;13:426-443. https://doi.org/10.1016/j.redox.2017.07.004
- Kruger C, Zhou Y. Red meat and colon cancer: a review of mechanistic evidence for heme in the context of risk assessment methodology. Food Chem Toxicol. 2018;118:131-153. https://doi.org/10.1016/j.fct.2018.04.048
- Fiorito V, Allocco AL, Petrillo S, Gazzano E, Torretta S, Marchi S, et al. The heme synthesis-export system regulates the tricarboxylic acid cycle flux and oxidative phosphorylation. Cell Reports. 2021;35(11):109252. https://doi.org/10.1016/j.celrep.2021.109252
- Hooda J, Cadinu D, Alam MM, Shah A, Cao TM, Sullivan LA, et al. Enhanced heme function and mitochondrial respiration promote the progression of lung cancer cells. PLoS One. 2013;8(5):e63402. https://doi.org/10.1371/journal.pone.0063402
- Hill M, Pereira V, Chauveau C, Zagani R, Remy S, Tesson L, et al. Heme oxygenase-1 inhibits rat and human breast cancer cell proliferation: mutual cross inhibition with indoleamine 2,3-dioxygenase. FASEB J. 2005;19(14):1957-1968. https://doi.org/10.1096/fj.05-3875com
- IJssennagger N, Rijnierse A, de Wit N, Jonker-Termont D, Dekker J, Muller M, et al. Dietary haem stimulates epithelial cell turnover by downregulating feedback inhibitors of proliferation in murine colon. Gut. 2012;61(7):1041-1049. https://doi.org/10.1136/gutjnl-2011-300239
- Ijssennagger N, Rijnierse A, de Wit NJ, Boekschoten MV, Dekker J, Schonewille A, et al. Dietary heme induces acute oxidative stress, but delayed cytotoxicity and compensatory hyperproliferation in mouse colon. Carcinogenesis. 2013;34(7):1628-1635. https://doi.org/10.1093/carcin/bgt084
- Sabharwal SS, Schumacker PT. Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles' heel? Nat Rev Cancer. 2014;14(11):709-721. https://doi.org/10.1038/nrc3803
- Namslauer I, Brzezinski P. A mitochondrial DNA mutation linked to colon cancer results in proton leaks in cytochrome c oxidase. Proc Natl Acad Sci U S A. 2009;106(9):3402-3407. https://doi.org/10.1073/pnas.0811450106
- Idelchik MD, Begley U, Begley TJ, Melendez JA. Mitochondrial ROS control of cancer. Semin Cancer Biol. 2017;47:57-66. https://doi.org/10.1016/j.semcancer.2017.04.005
- Luo KW, Xia J, Cheng BH, Gao HC, Fu LW, Luo XL. Tea polyphenol EGCG inhibited colorectal-cancer-cell proliferation and migration via downregulation of STAT3. Gastroenterol Rep (Oxf ). 2021;9(1):59-70. https://doi.org/10.1093/gastro/goaa072
- Cia D, Vergnaud-Gauduchon J, Jacquemot N, Doly M. Epigallocatechin gallate (EGCG) prevents H2O2-induced oxidative stress in primary rat retinal pigment epithelial cells. Curr Eye Res. 2014;39(9):944-952. https://doi.org/10.3109/02713683.2014.885532
- Osburn WO, Kensler TW. Nrf2 signaling: an adaptive response pathway for protection against environmental toxic insults. Mutat Res. 2008;659(1-2):31-39. https://doi.org/10.1016/j.mrrev.2007.11.006
- Kim YC, Masutani H, Yamaguchi Y, Itoh K, Yamamoto M, Yodoi J. Hemin-induced activation of the thioredoxin gene by Nrf2. A differential regulation of the antioxidant responsive element by a switch of its binding factors. J Biol Chem. 2001;276(21):18399-18406. https://doi.org/10.1074/jbc.M100103200
- Jang HY, Hong OY, Chung EY, Park KH, Kim JS. Roles of JNK/Nrf2 pathway on hemin-induced heme oxygenase-1 activation in MCF-7 human breast cancer cells. Medicina (Kaunas). 2020;56(6):268. https://doi.org/10.3390/medicina56060268
- Boyle JJ, Johns M, Lo J, Chiodini A, Ambrose N, Evans PC, et al. Heme induces heme oxygenase 1 via Nrf2: role in the homeostatic macrophage response to intraplaque hemorrhage. Arterioscler Thromb Vasc Biol. 2011;31(11):2685-2691. https://doi.org/10.1161/ATVBAHA.111.225813
- Han XD, Zhang YY, Wang KL, Huang YP, Yang ZB, Liu Z. The involvement of Nrf2 in the protective effects of (-)-epigallocatechin-3-gallate (EGCG) on NaAsO2-induced hepatotoxicity. Oncotarget. 2017;8(39):65302-65312. https://doi.org/10.18632/oncotarget.18582
- Sun W, Liu X, Zhang H, Song Y, Li T, Liu X, et al. Epigallocatechin gallate upregulates NRF2 to prevent diabetic nephropathy via disabling KEAP1. Free Radic Biol Med. 2017;108:840-857. https://doi.org/10.1016/j.freeradbiomed.2017.04.365
- Baumel-Alterzon S, Katz LS, Brill G, Garcia-Ocana A, Scott DK. Nrf2: the master and captain of beta cell fate. Trends Endocrinol Metab. 2021;32(1):7-19. https://doi.org/10.1016/j.tem.2020.11.002
- Pierre FH, Santarelli RL, Allam O, Tache S, Naud N, Gueraud F, et al. Freeze-dried ham promotes azoxymethane-induced mucin-depleted foci and aberrant crypt foci in rat colon. Nutr Cancer. 2010;62(5):567-573. https://doi.org/10.1080/01635580903532408
- Radulescu S, Brookes MJ, Salgueiro P, Ridgway RA, McGhee E, Anderson K, et al. Luminal iron levels govern intestinal tumorigenesis after Apc loss in vivo. Cell Reports. 2016;17(10):2805-2807. https://doi.org/10.1016/j.celrep.2016.10.028
- Rada P, Rojo AI, Offergeld A, Feng GJ, Velasco-Martin JP, Gonzalez-Sancho JM, et al. WNT-3A regulates an Axin1/NRF2 complex that regulates antioxidant metabolism in hepatocytes. Antioxid Redox Signal. 2015;22(7):555-571. https://doi.org/10.1089/ars.2014.6040
- Kim H, Yin K, Falcon DM, Xue X. The interaction of Hemin and Sestrin2 modulates oxidative stress and colon tumor growth. Toxicol Appl Pharmacol. 2019;374:77-85. https://doi.org/10.1016/j.taap.2019.04.025
- Kwak TW, Park SB, Kim HJ, Jeong YI, Kang DH. Anticancer activities of epigallocatechin-3-gallate against cholangiocarcinoma cells. Onco Targets Ther. 2016;10:137-144 https://doi.org/10.2147/OTT.S112364