대한임상검사과학회지 (Korean Journal of Clinical Laboratory Science)

  • 제54권3호
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  • Pages.167-172
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  • 2022
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  • 1738-3544(pISSN)
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  • 2288-1662(eISSN)
대한임상검사과학회 (Korean Society for Clinical Laboratory Science)
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ADA Levels in Body Fluids as the Preferred Test to Rule Out Tuberculosis in Limited-resource Settings: Data from a Tertiary Care Hospital in Northern India

  • Rasool, Rafia (Department of Clinical Biochemistry, Sher-I-Kashmir Institute of Medical Sciences (SKIMS)) ;
  • Rashid, Gowhar (Department of Clinical Biochemistry, Sher-I-Kashmir Institute of Medical Sciences (SKIMS)) ;
  • Mir, Shafat Ahmad (Department of Anaesthesiology, Sher-I-Kashmir Institute of Medical Sciences (SKIMS)) ;
  • Rather, Tahseen Bilal (Department of Clinical Biochemistry, Sher-I-Kashmir Institute of Medical Sciences (SKIMS)) ;
  • Mudassar, Syed (Department of Clinical Biochemistry, Sher-I-Kashmir Institute of Medical Sciences (SKIMS))
  • 투고 : 2022.06.15
  • 심사 : 2022.07.27
  • 발행 : 2022.09.30
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초록

In clinical practice, the diagnosis of tuberculosis (TB) continues to be a challenge. The goal of this study was to evaluate the reliability and impact of adenosine deaminase (ADA) enzyme testing as a biochemical marker in the continued management of suspected tuberculosis in a limited resource setting hospital. The retrospective data were collected from 2018 to 2021 and comprised the results of all ADA test assays done in the laboratory. All types of body fluids received for ADA testing were analyzed. Over the course of two years, 1461 samples for ADA assay testing were received. The average age of the study population was 56.69±11.7 years, with males accounting for the majority of the subjects (55.72%). Pleural fluid (N=817, 55.92%) was the most common type of sample received for the ADA assay. 114 (13.95%) of the 817 pleural fluid samples were found to be positive. A survey was conducted to obtain physician's response regarding reliability on ADA testing. 100% of them reported the supportive role of ADA levels in the workup of patients with suspected tuberculosis. In a limited resource setting, the ADA test, in conjunction with clinical and other laboratory findings, can help physicians to initiate early treatment in hospitals for the benefit of patients.

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과제정보

This manuscript is not the part of any thesis of any doctoral student but the arduous efforts of Gowhar Rashid and Dr. Rafia Rasool.The authors are highly thankful to the Dr. Tajamul Salim, Senior Resident Department of General Medicine, SKIMS for his support in circulation of questionnaire among the doctors of various specialities. The authors receive no financial support for the research, authorship, and/or publication of this article.

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