Journal of Biomedical Engineering Research (대한의용생체공학회:의공학회지)

The Korean Society of Medical and Biological Engineering (대한의용생체공학회)
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Changes of Blood pH in Micro-circulation System on the Stimulated Time of Pulsed Magnetic Fields

펄스자기장 자극 시간에 따른 미세순환시스템 내에서 혈액의 pH변화

  • Lee, Boram (Department of Oriental Biomedical Engineering, Sangji University) ;
  • Choi, Yukyung (Department of Oriental Biomedical Engineering, Sangji University) ;
  • Lee, Hyunsook (Department of Oriental Biomedical Engineering, Sangji University)
  • 이보람 (상지대학교 보건과학대학 한방의료공학과) ;
  • 최유경 (상지대학교 보건과학대학 한방의료공학과) ;
  • 이현숙 (상지대학교 보건과학대학 한방의료공학과)
  • Received : 2022.06.09
  • Accepted : 2022.07.26
  • Published : 2022.08.31
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Abstract

The purpose of this study was to investigate the role of the PMF in the treatment of acidosis and inflammation by monitoring the pH change for the continuity of PMF effect on the blood in the micro-circulation system that mimics the capillaries in the human body. Micro-tubes and micro-channels similar in diameter to those of arteries and arterioles were fabricated using PDMS and connected to a micro-pump for blood circulation. The continuity of PMF effect was verified in a micro-circulation system in-vitro. The pH changes for the circulating blood and for persistence time of PMF stimulus effect were confirmed using the optimized PMF conditions based on the previous studies. Also pH changes were observed by continuously stimulating PMF for a set period of time. The result was observed that the pH of the blood acidified using tBHP continued to rise from immediately after stimulation of PMF to 70 minutes of stimulation, reaching a normal pH range, and then decreasing. Our study showed that PMF has a positive effect on the control of blood pH homeostasis, so it is suggested the possibility of being used as a noninvasive treatment for acidosis treatment and anti- inflammatory treatment.

Keywords

Acknowledgement

이 논문은 교육과학기술부의 재원으로 한국연구재단의 이공분야 기초 연구사업(NRF-2021R1F1A1060167)의 지원으로 수행한 결과이다.

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