Journal of Biomedical Engineering Research (대한의용생체공학회:의공학회지)

The Korean Society of Medical and Biological Engineering (대한의용생체공학회)
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Synthesis of Size Controllable Silk Fibroin Microparticles and Their Stability on Different Solutions

  • Aryal, Susmita (Department of Biomedical Engineering, Yonsei University) ;
  • Yu, Chan Yeong (Department of Biomedical Engineering, Yonsei University) ;
  • Cho, Hyeyoun (Department of Biomedical Engineering, Yonsei University) ;
  • Choi, Seung Ho (Department of Biomedical Engineering, Yonsei University) ;
  • Key, Jaehong (Department of Biomedical Engineering, Yonsei University)
  • Received : 2022.07.27
  • Accepted : 2022.08.16
  • Published : 2022.08.31
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Abstract

Silk fibroin microparticles were fabricated using a phase separation technique between silk fibroin solution and polyvinyl alcohol. We found that the concentration of polyvinyl alcohol determines the size of microparticles. The mean diameter of the silk fibroin microparticles varied from 3.48 ㎛ to 4.05 ㎛. The silk fibroin microparticle size increased as a function of the concentration of PVA in aqueous silk solution. The resulting silk fibroin microparticles have narrow size distribution (i.e. monodisperse) and smooth/spherical surface. Also, we studied the effects of mouse serum, sodium phosphate buffer (PBS), and pH on the stability of the silk fibroin microparticles. Overall, we demonstrated the simple method to fabricate and to control the silk fibroin microparticles that makes our silk microparticles to be usable for a potential drug delivery carrier.

Keywords

Acknowledgement

This work was carried out with the support of "Cooperative Research Program for Agriculture Science & Technology Development (Project No. PJ015373)" Rural Development Administration, Republic of Korea.

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