Pediatric Gastroenterology, Hepatology & Nutrition

  • 제25권5호
  • /
  • Pages.422-431
  • /
  • 2022
  • /
  • 2234-8646(pISSN)
  • /
  • 2234-8840(eISSN)
대한소아소화기영양학회 (The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition)
권호 표지
DOI QR코드

DOI QR Code

SARS-CoV-2 Antibodies in Children with Chronic Disease from a Pediatric Gastroenterology Outpatient Clinic

  • Kaya, Gulay (Department of Pediatrics, Karadeniz Technical University Faculty of Medicine) ;
  • Issi, Fatma (Department of Pediatric Gastroenterology, Hepatology and Nutrition, Karadeniz Technical University Faculty of Medicine) ;
  • Guven, Burcu (Department of Pediatric Gastroenterology, Hepatology and Nutrition, Karadeniz Technical University Faculty of Medicine) ;
  • Ozkaya, Esra (Department of Microbiology, Karadeniz Technical University Faculty of Medicine) ;
  • Buruk, Celal Kurtulus (Department of Microbiology, Karadeniz Technical University Faculty of Medicine) ;
  • Cakir, Murat (Department of Pediatric Gastroenterology, Hepatology and Nutrition, Karadeniz Technical University Faculty of Medicine)
  • 투고 : 2022.01.24
  • 심사 : 2022.07.08
  • 발행 : 2022.09.15
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Purpose: At the beginning of the Coronavirus disease (COVID-19) epidemic, physicians paid close attention to children with chronic diseases to prevent transmission or a severe course of infection. We aimed to measure the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody levels in children with chronic gastrointestinal and liver diseases to analyze the risk factors for infection and its interaction with their primary disease. Methods: This cross-sectional study analyzed SARS-CoV-2 antibody levels in patients with gastrointestinal and liver diseases (n=141) and in healthy children (n=48) between January and February 2021. Results: During the pandemic, 10 patients (7%) and 1 child (2%) had confirmed COVID-19 infection (p=0.2). The SARS-CoV-2 antibody test was positive in 36 patients (25.5%) and 11 children (22.9%) (p=0.7). SARS-CoV-2 antibody positivity was found in 20.4%, 26.6%, 33.3%, and 33.3% of patients with chronic liver diseases, chronic gastrointestinal tract diseases, cystic fibrosis, and liver transplantation recipients, respectively (p>0.05, patients vs. healthy children). Risk factors for SARS-CoV-2 antibody positivity were COVID-19-related symptoms (47.2% vs. 14.2%, p=0.00004) and close contact with SARS-CoV-2 polymerase chain reaction-positive patients (69.4% vs. 9%, p<0.00001). The use, number, and type of immunosuppressants and primary diagnosis were not associated with SARS-CoV-2 antibody positivity. The frequency of disease activation/flare was not significant in patients with (8.3%) or without (14.2%) antibody positivity (p=0.35). Conclusion: SARS-CoV-2 antibodies in children with chronic gastrointestinal and liver diseases are similar to that in healthy children. Close follow-up is important to understand the long-term effects of past COVID-19 infection in these children.

키워드

참고문헌

  1. Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention. JAMA 2020;323:1239-42. https://doi.org/10.1001/jama.2020.2648
  2. Ludvigsson JF. Systematic review of COVID-19 in children shows milder cases and a better prognosis than adults. Acta Paediatr 2020;109:1088-95. https://doi.org/10.1111/apa.15270
  3. Akobeng AK, Grafton-Clarke C, Abdelgadir I, Twum-Barimah E, Gordon M. Gastrointestinal manifestations of COVID-19 in children: a systematic review and meta-analysis. Frontline Gastroenterol 2020;12:332-7
  4. Tullie L, Ford K, Bisharat M, Watson T, Thakkar H, Mullassery D, et al. Gastrointestinal features in children with COVID-19: an observation of varied presentation in eight children. Lancet Child Adolesc Health 2020;4:e19-20. https://doi.org/10.1016/S2352-4642(20)30165-6
  5. Cheung KS, Hung IFN, Chan PPY, Lung KC, Tso E, Liu R, et al. Gastrointestinal manifestations of SARS-CoV-2 infection and virus load in fecal samples from a Hong Kong cohort: systematic review and metaanalysis. Gastroenterology 2020;159:81-95. https://doi.org/10.1053/j.gastro.2020.03.065
  6. Assa A, Benninga MA, Borrelli O, Broekaert I, de Carpi JM, Saccomani MD, et al.; Gastrointestinal Committee of ESPGHAN. Gastrointestinal perspective of coronavirus disease 2019 in children-an updated review. J Pediatr Gastroenterol Nutr 2021;73:299-305. https://doi.org/10.1097/MPG.0000000000003204
  7. Roche Diagnostics GmbH. Elecsys® Anti-SARS-CoV-2 S assay [Internet]. Burgess Hill: Roche Diagnostics GmbH; 2022 [cited 2022 May 4]. Available from: https://diagnostics.Roche.com/gb/en/products/params/elecsys-anti-sars-cov-2-s.html
  8. Di Giorgio A, Hartleif S, Warner S, Kelly D. COVID-19 in children with liver disease. Front Pediatr 2021;9:616381.
  9. Sansotta N, Norsa L, Zuin G, Panceri R, Dilillo D, Pozzi E, et al. Children with inflammatory bowel disease in the COVID-19 main endemic focus: the Lombardy experience. Front Pediatr 2021;9:607285.
  10. Yuksel M, Akturk H, Mizikoglu O, Toroslu E, Arikan C. A single-center report of COVID-19 disease course and management in liver transplanted pediatric patients. Pediatr Transplant 2021;25:e14061.
  11. Corrias A, Cortes GM, Bardanzellu F, Melis A, Fanos V, Marcialis MA. Risk, course, and effect of SARS-CoV-2 infection in children and adults with chronic inflammatory bowel diseases. Children (Basel) 2021;8:753.
  12. Marjot T, Webb GJ, Barritt AS 4th, Moon AM, Stamataki Z, Wong VW, et al. COVID-19 and liver disease: mechanistic and clinical perspectives. Nat Rev Gastroenterol Hepatol 2021;18:348-64. https://doi.org/10.1038/s41575-021-00426-4
  13. Nicastro E, Ebel NH, Kehar M, Czubkowski P, Ng VL, Michaels MG, et al. The impact of severe acute respiratory syndrome coronavirus type 2 on children with liver diseases: a joint European Society for Pediatric Gastroenterology, Hepatology and Nutrition and Society of Pediatric Liver Transplantation position paper. J Pediatr Gastroenterol Nutr 2022;74:159-70. https://doi.org/10.1097/MPG.0000000000003339
  14. Kehar M, Ebel NH, Ng VL, Baquero JER, Leung DH, Slowik V, et al. Severe Acute respiratory syndrome coronavirus-2 infection in children with liver transplant and native liver disease: an international observational registry study. J Pediatr Gastroenterol Nutr 2021;72:807-14. https://doi.org/10.1097/MPG.0000000000003077
  15. Di Giorgio A, Nicastro E, Arnaboldi S, Montini O, Di Stasio F, D'Antiga L, et al. "Health status of children with chronic liver disease during the SARS-CoV-2 outbreak: results from a multicentre study". Clin Res Hepatol Gastroenterol 2021;45:101610.
  16. Tannuri U, Tannuri ACA, Cordon MNA, Miyatani HT. Low incidence of COVID-19 in children and adolescent post-liver transplant at a Latin American reference center. Clinics (Sao Paulo) 2020;75:e1986.
  17. Buescher G, Sebode M, Marjot T, Webb GJ, Moon AM, Barnes E, et al. SARS-CoV-2 in pediatric liver transplant recipients: the European experience. J Pediatr Gastroenterol Nutr 2022;74:e41-2. https://doi.org/10.1097/MPG.0000000000003325
  18. Sin P, Diaz LA, Martinez M, Vizcaya C, D'Agostino D, Gana JC. Acute liver injury among pediatric liver transplantation recipients with coronavirus disease 2019: an international collaborative study. J Pediatr Gastroenterol Nutr 2021;73:391-4. Erratum in: J Pediatr Gastroenterol Nutr 2022;74:171.
  19. Cakir M, Guven B, Issi F, Ozkaya E. New-onset celiac disease in children during COVID-19 pandemic. Acta Paediatr 2022;111:383-8. https://doi.org/10.1111/apa.16173
  20. Colmenero J, Rodriguez-Peralvarez M, Salcedo M, Arias-Milla A, Munoz-Serrano A, Graus J, et al. Epidemiological pattern, incidence, and outcomes of COVID-19 in liver transplant patients. J Hepatol 2021;74:148-55.
  21. Romanelli A, Mascolo S. Immunosuppression drug-related and clinical manifestation of Coronavirus disease 2019: a therapeutical hypothesis. Am J Transplant 2020;20:1947-8. https://doi.org/10.1111/ajt.15905
  22. Turner D, Huang Y, Martin-de-Carpi J, Aloi M, Focht G, Kang B, et al. Paediatric IBD Porto group of ESPGHAN. Corona virus disease 2019 and paediatric inflammatory bowel diseases: global experience and provisional guidance (March 2020) from the Paediatric IBD Porto Group of European Society of Paediatric Gastroenterology, Hepatology, and Nutrition. J Pediatr Gastroenterol Nutr 2020;70:727-33. https://doi.org/10.1097/MPG.0000000000002729